“2-methyleneglutarate mutase”的意思、由来-开放百科全书

词条

2-methyleneglutarate mutase

释义

References

{{enzyme
| Name = 2-methyleneglutarate mutase
| EC_number = 5.4.99.4
| CAS_number = 9059-10-3
| IUBMB_EC_number = 5/4/99/4
| GO_code = 0047548
| image =
| width =
| caption =
}}

In enzymology, a 2-methyleneglutarate mutase ({{EC number|5.4.99.4}}) is an enzyme that catalyzes the chemical reaction

2-methyleneglutarate 2-methylene-3-methylsuccinate

Hence, this enzyme has one substrate, 2-methyleneglutarate, and one product, 2-methylene-3-methylsuccinate.

This enzyme belongs to the family of isomerases, specifically those intramolecular transferases transferring other groups. The systematic name of this enzyme class is 2-methyleneglutarate carboxy-methylenemethylmutase. This enzyme is also called alpha-methyleneglutarate mutase. This enzyme participates in c5-branched dibasic acid metabolism. It employs one cofactor, cobamide.

References

{{cite journal |vauthors=Kung HF, Cederbaum S, Tsai L, Stadtman TC | date = 1970 | title = Nicotinic acid metabolism. V. A cobamide coenzyme-dependent conversion of alpha-methyleneglutaric acid to dimethylmaleic acid | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 65 | pages = 978–84 | pmid = 5266166 | doi = 10.1073/pnas.65.4.978 | issue = 4 | pmc = 283012 }}
{{cite journal |vauthors=Kung HF, Stadtman TC | date = 1971 | title = Nicotinic acid metabolism. VI. Purification and properties of alpha-methyleneglutarate mutase (B 12-dependent) and methylitaconate isomerase | journal = J. Biol. Chem. | volume = 246 | pages = 3378–88 | pmid = 5574401 | issue = 10 }}

3 : EC 5.4.99|Cobamide enzymes|Enzymes of unknown structure

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