“2-methylisocitrate dehydratase”的意思、由来-开放百科全书

词条

2-methylisocitrate dehydratase

释义

References

{{enzyme
| Name = 2-methylisocitrate dehydratase
| EC_number = 4.2.1.99
| CAS_number = 170780-51-5
| IUBMB_EC_number = 4/2/1/99
| GO_code = 0047456
| image =
| width =
| caption =
}}

In enzymology, a 2-methylisocitrate dehydratase ({{EC number|4.2.1.99}}) is an enzyme that catalyzes the chemical reaction

(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate (Z)-but-2-ene-1,2,3-tricarboxylate + H₂O

Hence, this enzyme has one substrate, (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate, and two products, (Z)-but-2-ene-1,2,3-tricarboxylate and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming]. This enzyme is also called (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate hydro-lyase. This enzyme participates in propanoate metabolism.

References

{{cite journal | doi = 10.1271/bbb.59.1825 |vauthors=Aoki H, Uchiyama H, Umetsu H, Tabuchi T | date = 1995 | title = Isolation of 2-methylisocitrate dehydratase, a new enzyme serving in the methylcitric acid cycle for propionate metabolism, from Yarrowia lipolytica | journal = Biosci. Biotechnol. Biochem. | volume = 59 | issue = 10 | pages = 1825–1828 }}
{{cite journal | doi = 10.1271/bbb.59.2013 |vauthors=Tabuchi T, Umetsu H, Aoki H, Uchiyama H | date = 1995 | title = Characteristics of 2-methylisocitrate dehydratase, isolated from Yarrowia lipolytica, in comparison to aconitase | journal = Biosci. Biotechnol. Biochem. | volume = 59 | issue = 11 | pages = 2013–2017 }}

2 : EC 4.2.1|Enzymes of unknown structure

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