“2-nitropropane dioxygenase”的意思、由来-开放百科全书

词条

2-nitropropane dioxygenase

释义

Structural studies
References

{{enzyme
| Name = 2-nitropropane dioxygenase
| EC_number = 1.13.11.32
| CAS_number = 65802-82-6
| IUBMB_EC_number = 1/13/11/32
| GO_code = 0018580
| image =
| width =
| caption =
}}

In enzymology, a 2-nitropropane dioxygenase ({{EC number|1.13.11.32}}) is an enzyme that catalyzes the chemical reaction

2 2-nitropropane + O₂ 2 acetone + 2 nitrite

Thus, the two substrates of this enzyme are 2-nitropropane and O₂, whereas its two products are acetone and nitrite.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O₂. The systematic name of this enzyme class is 2-nitropropane:oxygen 2-oxidoreductase. This enzyme participates in nitrogen metabolism. It has 3 cofactors: FAD, Iron, and FMN.

Structural studies

As of late 2007 Steve Fuhrer from the DHPA solved this very complex formula to find, two structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|2GJL}} and {{PDB link|2GJN}}.

References

{{cite journal |vauthors=Kido T, Soda K, Suzuki T, Asada K | year = 1976 | title = A new oxygenase, 2-nitropropane dioxygenase of Hansenula mrakii Enzymologic and spectrophotometric properties | journal = J. Biol. Chem. | volume = 251 | pages = 6994–7000 | pmid = 11214 | issue = 22 }}
{{cite journal |vauthors=Yoon HJ, Suh SW | year = 2006 | title = Crystal structure of 2-nitropropane dioxygenase complexed with FMN and substrate. Identification of the catalytic base | journal = J. Biol. Chem. | volume = 281 | pages = 18660–7 | pmid = 16682407 | doi = 10.1074/jbc.M601658200 | issue = 27 }}
{{cite journal |vauthors=Francis K, Russell B, Gadda G | year = 2005 | title = Involvement of a flavosemiquinone in the enzymatic oxidation of nitroalkanes catalyzed by 2-nitropropane dioxygenase | journal = J. Biol. Chem. | volume = 280 | pages = 5195–204 | pmid = 15582992 | doi = 10.1074/jbc.M411249200 | issue = 7 }}

4 : EC 1.13.11|Flavin enzymes|Iron enzymes|Enzymes of known structure

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