“2-oxoglutarate decarboxylase”的意思、由来-开放百科全书

词条

2-oxoglutarate decarboxylase

释义

References

{{enzyme
| Name = 2-oxoglutarate decarboxylase
| EC_number = 4.1.1.71
| CAS_number = 37205-42-8
| IUBMB_EC_number = 4/1/1/71
| GO_code = 0008683
| image =
| width =
| caption =
}}

In enzymology, a 2-oxoglutarate decarboxylase ({{EC number|4.1.1.71}}) is an enzyme that catalyzes the chemical reaction

2-oxoglutarate succinate semialdehyde + CO₂

Hence, this enzyme has one substrate, 2-oxoglutarate, and two products, succinate semialdehyde and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 2-oxoglutarate carboxy-lyase (succinate-semialdehyde-forming). Other names in common use include oxoglutarate decarboxylase, alpha-ketoglutarate decarboxylase, alpha-ketoglutaric decarboxylase, oxoglutarate decarboxylase, pre-2-oxoglutarate decarboxylase, and 2-oxoglutarate carboxy-lyase. It employs one cofactor, thiamin diphosphate.

References

{{cite journal |vauthors=Shigeoka S, Onishi T, Maeda K, Nakano Y, Kitaoka S | date = 1986 | title = Occurrence of thiamin pyrophosphate-dependent 2-oxoglutarate decarboxylase in mitochondria of Euglena gracilis | journal = FEBS Lett. | volume = 195 | pages = 43–47 | doi = 10.1016/0014-5793(86)80126-0 }}

3 : EC 4.1.1|Thiamine enzymes|Enzymes of unknown structure

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