1. References

In enzymology, a 2-oxoisovalerate dehydrogenase (acylating) ({{EC number|1.2.1.25}}) is an enzyme that catalyzes the chemical reaction

3-methyl-2-oxobutanoate + CoA + NAD⁺ 2-methylpropanoyl-CoA + CO₂ + NADH

The 3 substrates of this enzyme are 3-methyl-2-oxobutanoate, CoA, and NAD⁺, whereas its 3 products are 2-methylpropanoyl-CoA, CO₂, and NADH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-methyl-2-oxobutanoate:NAD+ 2-oxidoreductase (CoA-methyl-propanoylating). Other names in common use include 2-oxoisovalerate dehydrogenase, and alpha-ketoisovalerate dehydrogenase. This enzyme participates in valine, leucine and isoleucine degradation.

References

• {{cite journal |vauthors=Namba Y, Yoshizawa K, Ejima A, Hayashi T, Kaneda T | date = 1969 | title = Coenzyme A- and nicotinamide adenine dinucleotide-dependent branched chain alpha-keto acid dehydrogenase. I. Purification and properties of the enzyme from Bacillus subtilis | journal = J. Biol. Chem. | volume = 244 | pages = 4437–47 | pmid = 4308861 | issue = 16 }}

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