| 词条 | John Stanley Griffith |
| 释义 |
John Stanley Griffith (1928–1972) was a British chemist and biophysicist. His early work was in the inorganic chemistry of transition metal ions and ligand field theory.[1] During the 1960s, Griffith and radiation biologist Tikvah Alper developed the hypothesis that some transmissible spongiform encephalopathies (TSEs) are caused by an infectious agent consisting solely of proteins.[2][3] This idea was eventually developed by Prusiner and others into the so-called prion hypothesis. In 1951, when he was just 23, at Francis Crick's suggestion, Griffith performed quantum mechanical calculations on what later became known as complementary base pairing.[4] Griffith was the nephew of the distinguished British bacteriologist Frederick Griffith. See also
References1. ^{{cite web |url=http://www.biochemist.org/bio/02704/0033/027040033.pdf |title=From pabulum to prions (via DNA): a tale of two Griffiths |last=Lagnado |first=John |date=August 2005 |website=The Biochemist |publisher=Biochemical Society |access-date=3 July 2018 |quote=his first book, The Theory of Transition-Metal Ions, which had a lasting impact on inorganic chemistry and is arguably the definitive work in this field.}} {{Authority control}}{{DEFAULTSORT:Griffith, John Stanley}}{{UK-chemist-stub}}2. ^{{cite journal | vauthors = Alper T, Cramp WA, Haig DA, Clarke MC | title = Does the agent of scrapie replicate without nucleic acid? | journal = Nature | volume = 214 | issue = 5090 | pages = 764–6 | date = May 1967 | pmid = 4963878 | doi = 10.1038/214764a0 | bibcode = 1967Natur.214..764A }} 3. ^{{cite journal | vauthors = Griffith JS | title = Self-replication and scrapie | journal = Nature | volume = 215 | issue = 5105 | pages = 1043–4 | date = Sep 1967 | pmid = 4964084 | doi = 10.1038/2151043a0 | bibcode = 1967Natur.215.1043G }} 4. ^{{cite journal | author = John Lagnado | title = From pabulum to prions (via DNA): a tale of two Griffiths | journal = The Biochemist | pages = 33–35 | date = August 2005 |url=http://www.biochemist.org/bio/02704/0033/027040033.pdf}} 4 : 1928 births|1972 deaths|British chemists|British biophysicists |
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