| 词条 | 2-Thiouracil |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 470609135 | ImageFile = 2-Thiouracil.png | ImageSize = 120px | IUPACName = 2-Thioxo-1H-pyrimidin-4-one | OtherNames = |Section1 = {{Chembox Identifiers | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 1066108 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 59X161SCYL | InChI = 1/C4H4N2OS/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) | InChIKey = ZEMGGZBWXRYJHK-UHFFFAOYAK | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 345768 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C4H4N2OS/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = ZEMGGZBWXRYJHK-UHFFFAOYSA-N | CASNo_Ref = {{cascite|correct|CAS}} | CASNo = 141-90-2 | PubChem = 1269845 | ChEBI_Ref = {{ebicite|correct|EBI}} | ChEBI = 348530 | SMILES = O=C1\\C=C/NC(=S)N1 | MeSHName = Thiouracil | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = C19304 |Section2 = {{Chembox Properties | C=4 | H=4 | N=2 | O=1 | S=1 | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = |Section3 = {{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }} 2-Thiouracil is a specific molecule consisting of a sulfated uracil. Medical useThe substance is a historically relevant anti-thyroid preparation. Astwood E.B. used it in 1943 as therapy of Graves' disease for the first time.[1] It remains in use. Thiouracil inhibits thyroid activity by blocking the enzyme thyroid peroxidase.[2] Its use in recent times has been replaced by advent of more potent and safer antithyroid drugs. References1. ^{{cite book | url = https://books.google.com/books?id=LLoOUP-y54YC&pg=PA152&dq=parry+struma | author = Gerabek, W. | title = Enzyklopädie Medizingeschichte | page = 152 | year = 2005 | isbn = 978-3-11-015714-7}} {{Thyroid therapy}}{{Thyroid hormone receptor modulators}}{{DEFAULTSORT:Thiouracil2}}{{heterocyclic-stub}}2. ^{{cite journal | doi = 10.1210/jcem-43-1-152 | title = Effect of Antithyroid Agents 6-Propyl-2-Thiouracil and l-Methyl-2-Mercaptoimidazole on Human Thyroid Iodide Peroxidase | year = 1976 | last1 = Nagasaka | first1 = A. | last2 = Hidaka | first2 = H. | journal = Journal of Clinical Endocrinology & Metabolism | volume = 43 | pages = 152–8 | pmid=947933 | issue=1}} 4 : Pyrimidines|IARC Group 2B carcinogens|Thioureas|Nucleobases |
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