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词条 3alpha,7alpha,12alpha-trihydroxycholestan-26-al 26-oxidoreductase
释义

  1. Nomenclature

  2. References

{{enzyme
| Name = 3-alpha,7-alpha,12-alpha-trihydroxycholestan-26-al 26-oxidoreductase
| EC_number = 1.2.1.40
| CAS_number = 62213-58-5
| IUBMB_EC_number = 1/2/1/40
| GO_code = 0047103
| image =
| width =
| caption =
}}

In enzymology, a 3alpha,7alpha,12alpha-trihydroxycholestan-26-al 26-oxidoreductase is an enzyme that catalyzes the chemical reaction:[1]

(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + NAD+ + H2O (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + NADH + 2 H+

The 3 substrates of this enzyme are (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al, NAD+, and H2O, whereas its 2 products are (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate, NADH, and H+. This enzyme participates in bile acid biosynthesis.

Nomenclature

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al:NAD+ 26-oxidoreductase. Other names in common use include:

  • cholestanetriol-26-al 26-dehydrogenase,
  • 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al, dehydrogenase,
  • trihydroxydeoxycoprostanal dehydrogenase,
  • THAL-NAD oxidoreductase,
  • 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al:NAD+, and
  • 26-oxidoreductase.

References

1. ^{{cite journal | vauthors = Masui T, Herman R, Staple E | title = The oxidation of 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha, 26-tetraol to 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol-26-oic acid via 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol-26-al by rat liver | journal = Biochim. Biophys. Acta | volume = 117 | issue = 1 | pages = 266–8 |date=March 1966 | pmid = 5914340 | doi = 10.1016/0304-4165(66)90177-2}}
{{Aldehyde/Oxo oxidoreductases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{1.2-enzyme-stub}}{{biochem-stub}}

3 : EC 1.2.1|NADH-dependent enzymes|Enzymes of unknown structure

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