“3alpha-hydroxy-5beta-androstane-17-one 3alpha-dehydrogenase”的意思、由来-开放百科全书

词条

3alpha-hydroxy-5beta-androstane-17-one 3alpha-dehydrogenase

释义

References

{{enzyme
| Name = 3-alpha-hydroxy-5-beta-androstane-17-one 3-alpha-dehydrogenase
| EC_number = 1.1.1.152
| CAS_number = 37250-77-4
| IUBMB_EC_number = 1/1/1/152
| GO_code = 0047009
| image =
| width =
| caption =
}}

In enzymology, a 3alpha-hydroxy-5beta-androstane-17-one 3alpha-dehydrogenase ({{EC number|1.1.1.152}}) is an enzyme that catalyzes the chemical reaction

3alpha-hydroxy-5beta-androstane-17-one + NAD⁺ 5beta-androstane-3,17-dione + NADH + H⁺

Thus, the two substrates of this enzyme are 3alpha-hydroxy-5beta-androstane-17-one and NAD⁺, whereas its 3 products are 5beta-androstane-3,17-dione, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 3alpha-hydroxy-5beta-steroid:NAD⁺ 3-oxidoreductase. Other names in common use include etiocholanolone 3alpha-dehydrogenase, etiocholanolone 3alpha-dehydrogenase, and 3alpha-hydroxy-5beta-steroid dehydrogenase. This enzyme participates in androgen and estrogen metabolism.

References

{{cite journal |vauthors=Roe CR, Kaplan NO | date = 1969 | title = Purification and substrate specificities of bacterial hydroxysteroid dehydrogenases | journal = Biochemistry | volume = 8 | pages = 5093–103 | pmid = 5365796 | doi = 10.1021/bi00840a063 | issue = 12 }}

3 : EC 1.1.1|NADH-dependent enzymes|Enzymes of unknown structure

随便看

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。