“3'-demethylstaurosporine O-methyltransferase”的意思、由来-开放百科全书

词条

3'-demethylstaurosporine O-methyltransferase

释义

References

{{enzyme
| Name = 3'-demethylstaurosporine O-methyltransferase
| EC_number = 2.1.1.139
| CAS_number =
| IUBMB_EC_number = 2/1/1/139
| GO_code = 0030793
| image =
| width =
| caption =
}}

In enzymology, a 3'-demethylstaurosporine O-methyltransferase ({{EC number|2.1.1.139}}) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + 3'-demethylstaurosporine S-adenosyl-L-homocysteine + staurosporine

Thus, the two substrates of this enzyme are S-adenosyl methionine and 3'-demethylstaurosporine, whereas its two products are S-adenosylhomocysteine and staurosporine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:3'-demethylstaurosporine O-methyltransferase. Other names in common use include 3'-demethoxy-3'-hydroxystaurosporine O-methyltransferase, and staurosporine synthase.

References

{{cite journal | vauthors = Weidner S, Kittelmann M, Goeke K, Ghisalba O, Zähner H | title = 3'-Demethoxy-3'-hydroxystaurosporine-O-methyltransferase from Streptomyces longisporoflavus catalyzing the last step in the biosynthesis of staurosporine | journal = The Journal of Antibiotics | volume = 51 | issue = 7 | pages = 679–82 | date = July 1998 | pmid = 9727395 | doi=10.7164/antibiotics.51.679}}

2 : EC 2.1.1|Enzymes of unknown structure

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