“3-Hydroxybutyryl-CoA dehydrogenase”的意思、由来-开放百科全书

词条

3-Hydroxybutyryl-CoA dehydrogenase

释义

References

{{enzyme
| Name = 3-hydroxybutyryl-CoA dehydrogenase
| EC_number = 1.1.1.157
| CAS_number = 39319-78-3
| IUBMB_EC_number = 1/1/1/157
| GO_code = 0008691
| image =
| width =
| caption =
}}

In enzymology, a 3-hydroxybutyryl-CoA dehydrogenase ({{EC number|1.1.1.157}}) is an enzyme that catalyzes the chemical reaction

(S)-3-hydroxybutanoyl-CoA + NADP⁺ 3-acetoacetyl-CoA + NADPH + H⁺

Thus, the two substrates of this enzyme are (S)-3-hydroxybutanoyl-CoA and NADP⁺; its 3 products are acetoacetyl-CoA, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, to be specific those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (S)-3-hydroxybutanoyl-CoA:NADP⁺ oxidoreductase. Other names in common use include beta-hydroxybutyryl coenzyme A dehydrogenase, L-(+)-3-hydroxybutyryl-CoA dehydrogenase, BHBD, dehydrogenase, L-3-hydroxybutyryl coenzyme A (nicotinamide adenine, dinucleotide phosphate), L-(+)-3-hydroxybutyryl-CoA dehydrogenase, and beta-hydroxybutyryl-CoA dehydrogenase. This enzyme participates in benzoate degradation via coa ligation and butanoate metabolism.

References

{{cite journal | vauthors = Madan VK, Hillmer P, Gottschalk G | date = 1973 | title = Purification and properties of NADP-dependent L(+)-3-hydroxybutyryl-CoA dehydrogenase from Clostridium kluyveri | journal = Eur. J. Biochem. | volume = 32 | pages = 51–6 | pmid = 4405720 | doi = 10.1111/j.1432-1033.1973.tb02577.x | issue = 1 }}

3 : EC 1.1.1|NADPH-dependent enzymes|Enzymes of known structure

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