| 词条 | Justin Yerbury |
| 释义 |
| honorific_prefix = | name = Justin John Yerbury | honorific_suffix = | image = | image_size = | alt = | caption = | birth_name = | birth_date = 1974 | birth_place = Wollongong, New South Wales, Australia | death_date = | death_place = | death_cause = | nationality =Australian | citizenship = | education = BSc (Hons 1st class), University of Wollongong; PhD, University of Wollongong | occupation = Molecular biologist | years_active = | known_for = | relations = | website = | profession = | field = | work_institutions =Illawarra Health and Medical Research Institute (IHMRI), University of Wollongong | specialism = Research into the causes of MND | research_field = Protein misfolding and protein homeostasis | notable_works = | prizes =The Australian Society for Medical Research Young Investigator Award, 2004; Bill Gole Postdoctoral MND Research Fellowship, 2009; Vice Chancellor’s Emerging Researcher of the Year award, 2011; Lorne Conference on Protein Structure and Function Young Investigator Prize, 2012; MND Australia Betty Laidlaw MND Research Prize for 2017 | child = | module2 = | signature = }}Justin John Yerbury (born 1974) is an Australian molecular biologist who was spurred to follow a career in biological research when he discovered his family has the genetic form of motor neuron disease (MND). He was diagnosed in 2016 but continues to research. Education and careerBy his own admission, Yerbury "was not much of a scientist at school."[1] He studied for a Bachelor of Commerce before playing professional basketball[2] in the National Basketball League (NBL) for the Illawarra Hawks in 1995 and 1996[2] while helping to run the family business.[3] In the late 1990s members of Yerbury's extended family were diagnosed and passed away from motor neurone disease, also known as amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease. Ninety to ninety-five per cent of cases are considered sporadic, occurring randomly in the population. The remaining 5–10% of cases are Familial (Genetic) with one parent carrying the gene. Mutations of more than twelve genes have been found to cause the disease.[4] Using genealogical information Yerbury traced suspected cases of motor neuron disease in his family to at least 1920 and possibly further back.[5][3] He was prompted to return to university studies to further understand the disease. In 2004 Yerbury obtained a BSc with 1st class honours from the University of Wollongong.[6] He received his PhD from the same university in 2008 for a thesis titled: Characterisation of novel extracellular molecular chaperones and their effects on amyloid formation.[7] He worked as a research assistant, lecturer and research fellow during his studies. During 2008 and 2009 he was an Australian Research Council (ARC) International Linkage Fellow at the University of Cambridge, UK. Yerbury has been a Discovery Early Career Researcher Award (DECRA) Postdoctoral Fellow at the University of Wollongong since 2012. He has spent the last decade studying the disease which affects around 2000 Australians, alongside his team at the Illawarra Health and Medical Research Institute (IHMRI), based at the University of Wollongong.[8] His team of young researchers will carry on his work.[1] Personal lifeYerbury first knew of MND when his was uncle diagnosed in 1994. A cousin was diagnosed and died in 1997, he was 21 years old. During six-week period in 2002 his mother, grandmother and aunt passed away. Fifty per cent of Yerbury's family carry a faulty SOD-1 gene. His youngest sister passed away from MND at 26 years old. Yerbury and his sister, Naomi, were tested for the gene; Naomi was clear but Yerbury's test was positive.[5] Yerbury was diagnosed with MND in 2016.[13] His condition stabilised at first but he now requires around-the-clock care and has a ventilator to allow him to breathe. He was initially denied a suitable wheelchair and house modifications under the National Disability Insurance Scheme (NDIS), sparking an online crowdfunding campaign.[9] After coming to the attention of Federal Labor MP Sharon Bird, he was provided with an appropriate wheelchair and some home modifications under the scheme.[10] Yerbury's public profile has also highlighted others who encountered difficulties with the NDIS.[10] Yebury highlighted the difficulties MND patients encounter with the NDIS in an article in The Conversation in November 2018. {{Quote|text=A problem at the core of all MND-related difficulties with the NDIS is that the projected short lifespan of those with MND makes the NDIS baulk at funding high-cost items and modifications.We are not perceived as being “value for money”.|sign=Justin Yerbury|source=The Conversation, November 5, 2018[11]}} In January 2018 Yerbury's condition deteriorated significantly and he underwent a tracheostomy necessitating mandatory ventilation. To further facilitate his life support he also had a laryngectomy which means he is unable to speak. He now communicates by lip reading and using voice software coordinated by eye-gaze on his laptop computer.[5] After this surgery Yerbury spent six months in hospital recovering with complications. In November 2018 he had returned home and began attending his office two days a week to continue his research.[12] In April 2017 Yerbury met Stephen Hawking, a world-famous physicist and cosmologist who had MND for over fifty years until his death in 2018. They discussed living with the disease and Yerbury's research.[8][13][1] Yerbury is married to Rachel Yerbury. They have two daughters: Talia Delphina Yerbury, born 1996, and Maddison Raini Yerbury, born 1998. Research{{Quote|text=“It was clear at the time that there was not enough understanding of the molecular basis of the disease to develop an effective therapeutic. I have, as a result dedicated myself to increasing the understanding of the origins of motor neurone disease.”|sign=Dr Justin Yerbury|source=[23]}}Yerbury is researching potential effective treatments for MND. His research interests include: protein misfolding, aggregation and neurodegenerative disease, protein aggregation and neuro-inflammation and the Propagation of protein misfolding, and protein homeostasis and Motor Neurone Disease.[6] This video shows Yerbury demonstrating the role of protein folding in the progress of MND.[14] His team studies single molecules of protein, grow cells and are carrying out some drug trials.[15] He has been active in sharing his research not only with the academic community but also with those with MND and their families.[16][17] Yerbury has 55 research articles listed in PubMed[18] in addition to many conference and other presentations. Awards
References1. ^1 2 {{Cite news|url=http://www.abc.net.au/news/2018-03-26/justin-yerburys-fight-again-motor-neurone-disease/9570748|title=Justin Yerbury has motor neurone disease. Now he's racing against time to find a cure|date=2018-03-26|work=ABC News|access-date=2018-03-27|language=en-AU}} {{Authority Control}}{{DEFAULTSORT:Yerbury, Justin}}2. ^{{Cite web|url=http://websites.sportstg.com/team_info.cgi?action=PSTATS&pID=194195471&client=11-8739-124009-199547-16568037|title=Justin Yerbury - Player Statistics|website=SportsTG|language=en|access-date=2018-03-28}} 3. ^1 2 {{Cite web|url=http://www.abc.net.au/health/yourstories/stories/2014/05/09/4000753.htm|title=Motor Neurone Disease - my family's story - Health & Wellbeing|last=Australian Broadcasting Corporation|first=(ABC)|date=|website=www.abc.net.au|archive-url=|archive-date=|dead-url=|access-date=2018-03-28}} 4. ^{{Cite web|url=https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Amyotrophic-Lateral-Sclerosis-ALS-Fact-Sheet|title=Amyotrophic Lateral Sclerosis (ALS) Fact Sheet {{!}} National Institute of Neurological Disorders and Stroke|website=www.ninds.nih.gov|access-date=2018-03-28}} 5. ^1 2 {{Citation|title=The Enemy Within: Australian Story episode. (includes transcript)|date=2018-03-21|url=http://www.abc.net.au/austory/the-enemy-within/9572042|publisher=Australian Broadcasting Corporation|language=en-AU|accessdate=2018-03-28}} 6. ^1 2 3 {{Cite web|url=https://smah.uow.edu.au/biol/contacts/UOW066703.html|title=Dr Justin Yerbury|website=smah.uow.edu.au|language=en-au|others=hallingu|access-date=2018-03-28}} 7. ^{{Cite book|url=http://iii.library.uow.edu.au/search/X?SEARCH=a:(yerbury,%20j)&SORT=D&m=l|title=Characterisation of novel extracellular molecular chaperones and their effects on amyloid formation. Thesis (Ph.D.)--University of Wollongong, 2007|last=Yerbury|first=Justin J.|date=2007|publisher=|others=University of Wollongong|year=|isbn=|location=|pages=}} 8. ^1 {{Cite news|url=http://www.illawarramercury.com.au/story/5302172/mnd-researcher-dr-justin-yerbury-fights-for-a-cure-and-his-life/|title=MND researcher Dr Justin Yerbury fights for a cure – and his life|last=Wachsmuth|first=Lisa|date=2018-03-26|work=Illawarra Mercury|access-date=2018-03-28|language=en}} 9. ^{{Cite web|url=https://www.gofundme.com/fundraising-for-justin|title=Fundraising for Justin organised by Naomi Yerbury|last=|first=|date=|website=gofundme.com|language=en-US|archive-url=|archive-date=|dead-url=|access-date=2018-03-28}} 10. ^1 2 {{Cite news|url=http://www.abc.net.au/news/2018-03-10/concerns-about-motor-neurone-disease-ndis/9533350|title=Concerns motor neurone patients slipping through cracks|date=2018-03-10|work=ABC News|access-date=2018-03-28|language=en-AU}} 11. ^{{Cite news|url=https://theconversation.com/some-diseases-like-mine-deteriorate-rapidly-disability-services-need-to-keep-up-106157|title=Some diseases, like mine, deteriorate rapidly – disability services need to keep up|last=Yerbury|first=Justin|work=The Conversation|access-date=2018-11-10|language=en}} 12. ^{{Citation|last=|first=|title=No Surrender, Australian Story episode (includes transcript)|date=2018-11-01|url=https://www.abc.net.au/austory/no-surrender/10456238|volume=|pages=|publisher=Australian Broadcasting Corporation|language=en-AU|access-date=2018-11-10}} 13. ^{{Cite news|url=http://www.abc.net.au/news/2018-03-26/justin-yerburys-meeting-with-stephen-hawking/9576778|title=How Stephen Hawking inspired me to take drastic measures against motor neurone disease|date=2018-03-26|work=ABC News|access-date=2018-03-28|language=en-AU}} 14. ^{{Citation|last=University of Wollongong|title=Budding Ideas - May 2014 - Dr Justin Yerbury|date=2014-07-03|url=https://www.youtube.com/watch?v=kMdUy3ootSs&t=17s|accessdate=2018-03-28}} 15. ^{{Citation|last=UOWTV Multimedia|title=National Motor Neurone Disease Week|date=2014-05-05|url=https://www.youtube.com/watch?v=YIYzoRFSshs|accessdate=2018-03-28}} 16. ^{{Citation|last=The Motor Neurone Disease Association of NSW|title=2015 Ask the Experts 3 What’s new in MND Research? Part A - Dr Justin Yerbury|date=2015-08-04|url=https://www.youtube.com/watch?v=3XhTaIDqTLo|accessdate=2018-03-28}} 17. ^{{Citation|last=The Motor Neurone Disease Association of NSW|title=2015 Ask the Experts 4 What’s new in MND Research? Part B Questions - Dr Justin Yerbury|date=2015-08-04|url=https://www.youtube.com/watch?v=06Qdm13RE2I|accessdate=2018-03-28}} 18. ^{{Cite web|url=https://www.ncbi.nlm.nih.gov/pubmed?term=Justin+Yerbury&cmd=DetailsSearch|title=Justin Yerbury - PubMed - NCBI|last=|first=|date=|website=www.ncbi.nlm.nih.gov|language=en|archive-url=|archive-date=|dead-url=|access-date=2018-11-10}} 19. ^{{Cite journal|last=|first=|date=December 2008|title=MND research fellowships and scholarships|url=|journal=Motor Neurone Disease Research Institute of Australia Annual Review|volume=|pages=5|via=}} 20. ^{{Cite web|url=https://www.uow.edu.au/about/vcawards/archive/UOW077356.html|title=VC Awards 2011 Recipients|last=|first=|date=|website=www.uow.edu.au|language=en-au|others=aclode|archive-url=|archive-date=|dead-url=|access-date=2018-03-28}} 21. ^{{Cite web|url=http://www.lorneproteins.org/past-award-winners/|title=Past Award Winners » Lorne Proteins|website=www.lorneproteins.org|language=en-AU|access-date=2018-03-28}} 22. ^{{Cite web|url=http://www.mndnsw.asn.au/blog/210-december-2017/1187-nsw-researcher-awarded-mnd-research-prize-for-2017.html|title=NSW researcher awarded MND Research Prize for 2017|last=|first=|date=|website=www.mndnsw.asn.au|language=en-gb|archive-url=|archive-date=|dead-url=|access-date=2018-03-28}} 23. ^1 {{Cite web|url=https://media.uow.edu.au/releases/UOW240217.html|title=IHMRI scientist wins motor neurone disease research prize|website=media.uow.edu.au|language=en-au|others=benl|access-date=2018-03-28}} 24. ^{{Cite web|url=http://www.mndaust.asn.au/Discover-our-research/Latest-research/Research-reports.aspx|title=MND research grants|last=|first=|date=|website=MND Australia|archive-url=|archive-date=|dead-url=|access-date=2018-03-28}} 25. ^{{Cite web|url=https://www.illawarramercury.com.au/story/5864096/motor-neurone-disease-advocate-and-sufferer-named-wollongongs-citizen-of-the-year/|title=Motor Neurone Disease advocate and sufferer named Wollongong's Citizen of the Year|last=Tullis|first=Ashleigh|date=2019-01-22|website=Illawarra Mercury|language=en|archive-url=|archive-date=|dead-url=|access-date=2019-01-24}} 6 : Australian basketball players|Australian biologists|1974 births|Living people|University of Wollongong faculty|Illawarra Hawks players |
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