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词条 3'-Phosphoadenosine-5'-phosphosulfate
释义

  1. Formation and reduction

  2. References

{{Redirect|PAPS|other uses|Paps (disambiguation)}}{{chembox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 477216937
| ImageFile=3'-Phosphoadenosine-5'-phosphosulfate.svg
| ImageSize=200px
| IUPACName=6-Amino-9-[(2R,3R,4S,5R)-3-hydroxy-5-

[(hydroxy-sulfooxy-phosphoryl)oxymethyl]

-4-phosphonooxy-oxolan-2-yl]purine
| OtherNames=PAPS
3'-phosphoadenylyl sulfate
phosphoadenosine phosphosulfate
3'-phospho-5'-adenylyl sulfate
|Section1={{Chembox Identifiers
| Abbreviations = PAPS
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 9799
| InChI = 1/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/t4-,6-,7-,10-/m1/s1
| InChIKey = GACDQMDRPRGCTN-KQYNXXCUBK
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/t4-,6-,7-,10-/m1/s1
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = GACDQMDRPRGCTN-KQYNXXCUSA-N
| CASNo_Ref = {{cascite|changed|??}}
| CASNo= 482-67-7
| PubChem=10214
| IUPHAR_ligand = 1719
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 17980
| SMILES = C1=NC2=C(C(=N1)N)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)OS(=O)(=O)O)OP(=O)(O)O)O
}}
|Section2={{Chembox Properties
| Formula=C10H15N5O13P2S
| MolarMass=507.266
| Appearance=
| Density=
| MeltingPt=
| BoilingPt=
| Solubility=
|Section3={{Chembox Hazards
| MainHazards=
| FlashPt=
| AutoignitionPt =
}}3'-Phosphoadenosine-5'-phosphosulfate (PAPS) is a derivative of adenosine monophosphate that is phosphorylated at the 3' position and has a sulfate group attached to the 5' phosphate. It is the most common coenzyme in sulfotransferase reactions. It is endogenously synthesized by organisms via the phosphorylation of adenosine 5'-phosphosulfate (APS), an intermediary metabolite.[1] In humans such reaction is performed by bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthases (PAPSS1 and PAPSS2) using ATP as the phosphate donor.[2]

Formation and reduction

APS and PAPS are intermediates in the reduction of sulfate to sulfite, an exothermic conversion that is carried out by sulfate-reducing bacteria. In these organisms, sulfate serves as an electron acceptor, akin to the use of O2 as an electron acceptor by aerobic organisms. Sulfate is not reduced directly but must be activated by the formation of APS or PAPS. These carriers of activated sulfate are produced by reaction with ATP. The first reaction is catalysed by ATP sulfurylase:

SO42− + ATP → APS + PPi

The conversion of APS to PAPS is catalysed by APS kinase:

APS + ATP → PAPS + ADP

Reduction of APS leads to sulfite, which is further reduced to hydrogen sulfide, which is excreted. This process is called dissimilatory sulfate reduction. Reduction of PAPS, a more elaborated sulfate ester, leads also to hydrogen sulfide. But in this case, the product is used in biosynthesis, e.g. for the production of cysteine. The latter process is called assimilatory sulfate reduction because the sulfate sulfur is assimilated.[3]

References

1. ^{{cite journal |author =Negishi M |author2 =Pedersen LG |author3 =Petrotchenko E |title=Structure and function of sulfotransferases |journal=Arch. Biochem. Biophys. |volume=390 |issue=2 |pages=149–57 |year=2001 |pmid=11396917 |doi=10.1006/abbi.2001.2368|display-authors=etal}}
2. ^{{cite journal|last1=Xu|first1=Zhen-Hua|last2=Otterness|first2=Diane M.|last3=Freimuth|first3=Robert R.|last4=Carlini|first4=Edward J.|last5=Wood|first5=Thomas C.|last6=Mitchell|first6=Steve|last7=Moon|first7=Eunpyo|last8=Kim|first8=Ung-Jin|last9=Xu|first9=Jing-Ping|last10=Siciliano|first10=Michael J.|last11=Weinshilboum|first11=Richard M.|title=Human 3′-Phosphoadenosine 5′-Phosphosulfate Synthetase 1 (PAPSS1) and PAPSS2: Gene Cloning, Characterization and Chromosomal Localization|journal=Biochemical and Biophysical Research Communications|date=February 2000|volume=268|issue=2|pages=437–444|doi=10.1006/bbrc.2000.2123|pmid=10679223}}
3. ^M. T. Madigan, J. M. Martinko, J. Parker “Brock Biology of Microorganisms” Prentice Hall, 1997. {{ISBN|0-13-520875-0}}.
{{Enzyme cofactors}}{{DEFAULTSORT:Phosphoadenosine-5'-phosphosulfate, 3'-}}

3 : Nucleotides|Coenzymes|Sulfur metabolism
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