| 词条 | 4,4'-Methylenebis(2-chloroaniline) |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 477220646 | ImageFile_Ref = {{chemboximage|correct|??}} | ImageFile=Bisamine.png |ImageSize=200px |IUPACName=4-[(4-Amino-3-chlorophenyl)methyl]-2-chloroaniline |OtherNames=•4,4'-Methylene-bis(2-chloroaniline) •Cyanaset •Quodorole •Dacpm •Curalin M •Diamet Kh •Millionate M •Bis amine •MOCA •Bisamine S |Section1= {{Chembox Identifiers | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = C10999 | InChI = 1/C13H12Cl2N2/c14-10-6-8(1-3-12(10)16)5-9-2-4-13(17)11(15)7-9/h1-4,6-7H,5,16-17H2 | InChIKey = IBOFVQJTBBUKMU-UHFFFAOYAI | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 82846 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C13H12Cl2N2/c14-10-6-8(1-3-12(10)16)5-9-2-4-13(17)11(15)7-9/h1-4,6-7H,5,16-17H2 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = IBOFVQJTBBUKMU-UHFFFAOYSA-N | CASNo_Ref = {{cascite|correct|CAS}} | CASNo=101-14-4 | UNII_Ref = {{fdacite|changed|FDA}} | UNII = 3L2W5VTT2A | PubChem=7543 | SMILES = Clc1cc(ccc1N)Cc2ccc(N)c(Cl)c2 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID=7262 |Section2= {{Chembox Properties | C=13|H=12|Cl=2|N=2 | Appearance=Tan-colored pellets or flakes[1] | Density=1.44 g/cm3[1] | MeltingPtC = 104 to 109 | MeltingPt_ref = [1] | BoilingPt= | Solubility=insoluble | Odor = faint, amine-like[1] | VaporPressure = 0.00001 mmHg (20 °C)[1] |Section3= {{Chembox Hazards | NFPA-H = 2 | NFPA-F = 1 | NFPA-R = 0 | MainHazards= potential occupational carcinogen[1] | FlashPtC =203 | AutoignitionPtC = | PEL = none[2] | IDLH = Ca [N.D.][2] | REL = Ca TWA 0.003 mg/m3 [skin][2] }}4,4'-Methylenebis(2-chloroaniline) (also known as MOCA, MBOCA, and bisamine) is a substance used as a curing agent in polyurethane production.[3] MOCA is an aromatic amine which is structurally similar to benzidine, a known human bladder carcinogen. MOCA has been shown to cause hepatomas in mice and rats, lung and mammary carcinomas in rats and bladder cancer in dogs. It is a proven human carcinogen standing on the WHO List of IARC Group 1 carcinogens, with a current threshold limit value of 0.01 ppm in the industrial atmosphere. Animal studies have resulted in tumor growth in the liver, lung, and bladder.[2] Employee exposure is often monitored by measurement of urinary MOCA in free and/or conjugated form.[4] The best currently available indicator of absorption of MOCA is urinary total MOCA estimations based on spot creatinine corrected urines. Although this method is not without limitations, that is unmetabolised MOCA is measured and dose-response curves are lacking, its use is a reasonable means of monitoring the effectiveness of engineering controls, personal protective equipment and work practices including education. MOCA levels are usually higher at the end of the shift and reflect exposure over the preceding two to three days. The biological half-life of MOCA in urine is approximately 23 hours. It is a weak base with a slight odor and is reactive to active metals such as sodium, potassium, magnesium and zinc.[2] References1. ^{{cite web | url = http://www.tcichemicals.com/eshop/en/gb/commodity/M0609 | publisher = TCI Chemicals | title = 4,4'-Methylenebis(2-chloroaniline) | accessdate = March 17, 2014}} {{DEFAULTSORT:Methylenebis(2-chloroaniline), 4,4'-}}2. ^1 2 3 4 5 6 7 8 9 {{PGCH|0411}} 3. ^RTK HSFS 1250 4. ^[https://web.archive.org/web/20040224185448/http://www.osha.gov/SLTC/healthguidelines/4-4-methylenebis-2-chloroaniline/index.html 4,4'-Methylene bis (2-chloroaniline) Health Guideline], Occupational Safety and Health Administration 3 : Anilines|Chloroarenes|IARC Group 1 carcinogens |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。