| 词条 | 4-Aminosalicylic acid |
| 释义 |
| Watchedfields = changed | verifiedrevid = 477221040 | IUPAC_name = 4-Amino-2-hydroxybenzoic acid | image = P-Aminosalicylic acid.svg | width = 200 | image2 = 4-Aminosalicylic_acid_3d_structure.png | width2 = 150 | tradename = Paser | Drugs.com = {{drugs.com|monograph|aminosalicylic-acid}} | pregnancy_category = C | legal_UK = POM | routes_of_administration = by mouth | bioavailability = | protein_bound = 50–60% | metabolism = liver | elimination_half-life = | excretion = kidney | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 65-49-6 | CAS_supplemental = | ATC_prefix = J04 | ATC_suffix = AA01 | ATC_supplemental = | PubChem = 4649 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = DB00233 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 4488 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 5B2658E0N2 | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D00162 | ChEBI_Ref = {{ebicite|correct|EBI}} | ChEBI = 27565 | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 1169 | NIAID_ChemDB = 020064 | C=7 | H=7 | N=1 | O=3 | molecular_weight = 153.135 g/mol | smiles = O=C(O)c1ccc(cc1O)N | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C7H7NO3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9H,8H2,(H,10,11) | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = WUBBRNOQWQTFEX-UHFFFAOYSA-N | melting_point = 150.5 }}4-Aminosalicylic acid, also known as para-aminosalicylic acid (PAS) is an antibiotic primarily used to treat tuberculosis.[1] Specifically it is used to treat active drug resistant tuberculosis together with other antituberculosis medications.[2] It has also been used as a second line agent to sulfasalazine in people with inflammatory bowel disease such as ulcerative colitis and Crohn's disease.[2] It is typically taken by mouth.[2] Common side effects include nausea, abdominal pain, and diarrhea.[2] Other side effects may include liver inflammation and allergic reactions.[2] It is not recommended in people with end stage kidney disease.[2] While there does not appear to be harm with use during pregnancy it has not been well studied in this population.[2] 4-Aminosalicylic acid is believed to work by blocking the ability of bacteria to make folic acid.[2] 4-Aminosalicylic acid was first made in 1902 and came into medical use in 1943.[3] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[4] As of 2005 a course of treatment for tuberculosis costs about US$2,700.[5] Medical usesThe main use for 4-aminosalicylic acid is for the treatment of tuberculosis infections. TuberculosisAminosalicylic acid was introduced to clinical use in 1944. It was the second antibiotic found to be effective in the treatment of tuberculosis, after streptomycin. PAS formed part of the standard treatment for tuberculosis prior to the introduction of rifampicin and pyrazinamide.[6] Its potency is less than that of the current five first-line drugs (isoniazid, rifampicin, ethambutol, pyrazinamide, and streptomycin) for treating tuberculosis and its cost is higher, but it is still useful in the treatment of multidrug-resistant tuberculosis.[14] PAS is always used in combination with other anti-TB drugs. The dose when treating tuberculosis is 150 mg/kg/day divided into two to four daily doses; the usual adult dose is therefore approximately 2 to 4 grams four times a day. It is sold in the US as "Paser" by Jacobus Pharmaceutical, which comes in the form of 4 g packets of delayed-release granules. The drug should be taken with acid food or drink (orange, apple or tomato juice).[7] PAS was once available in a combination formula with isoniazid called Pasinah[8] or Pycamisan 33.[9] The European Medicines Agency (EMA) has recommended granting a marketing authorization for PAS in multidrug-resistant tuberculosis in adults and children when other treatments cannot "be devised for reasons of resistance or tolerability."[10] Inflammatory bowel diseasePAS has also been used in the treatment of inflammatory bowel disease (ulcerative colitis and Crohn's disease),[11] but has been superseded by other drugs such as sulfasalazine and mesalazine. OthersPAS has been investigated for the use in manganese chelation therapy, and a 17-year follow-up study shows that it might be superior to other chelation protocols such as EDTA.[12] Side effectsGastrointestinal side-effects (nausea, vomiting, diarrhoea) are common; the delayed-release formulation is meant to help overcome this problem.[13] It is also a cause of drug-induced hepatitis. Patients with glucose-6-phosphate dehydrogenase deficiency should avoid taking aminosalicylic acid as it causes haemolysis.[14] Thyroid goitre is also a side-effect because aminosalicylic acid inhibits the synthesis of thyroid hormones.[15] Drug interactions include elevated phenytoin levels. When taken with rifampicin, the levels of rifampicin in the blood fall by about half.[16] The U.S. FDA assigned PAS to pregnancy category C, indicating that it is not known whether it will harm an unborn baby. PharmacologyWith heat, aminosalicylic acid is decarboxylated to produce CO2 and 3-aminophenol.[17] Mode of actionPAS has been shown to be a pro-drug and it is incorporated into the folate pathway by dihydropteroate synthase (DHPS) and dihydrofolate synthase (DHFS) to generate a hydroxyl dihydrofolate antimetabolite, which in turn inhibits dihydrofolate reductase (DHFR) enzymatic activity.[18] HistoryPAS was first synthesized by Seidel and Bittner in 1902.[3] It was rediscovered by the Swedish chemist Jörgen Lehmann upon the report that the tuberculosis bacterium avidly metabolized salicylic acid.[19] Lehmann first tried PAS as an oral TB therapy late in 1944. The first patient made a dramatic recovery.[20] The drug proved better than streptomycin, which had nerve toxicity and to which TB could easily develop resistance. In the 1948, researchers at Britain's Medical Research Council demonstrated that combined treatment with streptomycin and PAS was superior to either drug alone, and established the principle of combination therapy for tuberculosis.[21][3] Other namesLike many commercially significant compounds, PAS has many names including para-aminosalicylic acid, p-aminosalicylic acid, 4-ASA, and simply P. References1. ^{{cite book|title=WHO Model Formulary 2008|date=2009|publisher=World Health Organization|isbn=9789241547659|page=140|url=http://apps.who.int/medicinedocs/documents/s16879e/s16879e.pdf|accessdate=8 December 2016|deadurl=no|archiveurl=https://web.archive.org/web/20161213060118/http://apps.who.int/medicinedocs/documents/s16879e/s16879e.pdf|archivedate=13 December 2016|df=}} 2. ^1 2 3 4 5 6 7 {{cite web|title=Aminosalicylic Acid|url=https://www.drugs.com/monograph/aminosalicylic-acid.html|publisher=The American Society of Health-System Pharmacists|accessdate=8 December 2016|deadurl=no|archiveurl=https://web.archive.org/web/20161220231049/https://www.drugs.com/monograph/aminosalicylic-acid.html|archivedate=20 December 2016|df=}} 3. ^1 2 {{Cite journal|last=Donald|first=Peter R|last2=Diacon|first2=Andreas H|title=Para-aminosalicylic acid: the return of an old friend|url=http://linkinghub.elsevier.com/retrieve/pii/S1473309915002637|journal=The Lancet Infectious Diseases|volume=15|issue=9|pages=1091–1099|doi=10.1016/s1473-3099(15)00263-7}} 4. ^{{cite web|title=WHO Model List of Essential Medicines (19th List)|url=http://www.who.int/medicines/publications/essentialmedicines/EML_2015_FINAL_amended_NOV2015.pdf?ua=1|work=World Health Organization|accessdate=8 December 2016|date=April 2015|deadurl=no|archiveurl=https://web.archive.org/web/20161213052708/http://www.who.int/medicines/publications/essentialmedicines/EML_2015_FINAL_amended_NOV2015.pdf?ua=1|archivedate=13 December 2016|df=}} 5. ^{{cite book|last1=Brown|first1=Garrett W.|last2=Yamey|first2=Gavin|last3=Wamala|first3=Sarah|title=The Handbook of Global Health Policy|publisher=John Wiley & Sons|isbn=9781118509609|url=https://books.google.ca/books?id=gINYAwAAQBAJ&pg=PT338|language=en|chapter=Chapter 12|deadurl=no|archiveurl=https://web.archive.org/web/20161220085657/https://books.google.ca/books?id=gINYAwAAQBAJ&pg=PT338|archivedate=2016-12-20|df=}} 6. ^{{cite journal|author =Mitchison DA|title=Role of individual drugs in the chemotherapy of tuberculosis Role of individual drugs in the chemotherapy of tuberculosis|journal=Int J Tuberc Lung Dis|volume=4|issue=9|pages=796–806|pmid=10985648|year=2000}} 7. ^{{cite web|title=Paser |publisher=RxList |url=http://www.rxlist.com/cgi/generic/paser.htm |accessdate=2008-10-10 |archiveurl=https://web.archive.org/web/20080913183444/http://www.rxlist.com/cgi/generic/paser.htm |archivedate=September 13, 2008 |deadurl=yes }} 8. ^{{cite journal|title=Lichen scrofulosorum: A report of four cases|vauthors=Smith NP, Ryan TJ, Sanderson KV, Sarkany I |journal=Br J Dermatol|volume=94|issue=3|pages=319–325|doi=10.1111/j.1365-2133.1976.tb04391.x|pmid=1252363|year=1976}} 9. ^{{cite journal|title=Two incidents of tuberculous infection by milk from attested herds|author =Black JM|journal=Br Med J|pages=1732–1735|year=1961|pmid=20789163|doi=10.1136/bmj.1.5241.1732|last2=Sutherland|first2=IB|volume=1|issue=5241|pmc=1954350}} 10. ^Drug Discovery & Development. EMA Recommends Two New Tuberculosis Treatments. {{webarchive|url=https://web.archive.org/web/20131203022613/http://www.ema.europa.eu/ema/index.jsp?curl=pages%2Fnews_and_events%2Fnews%2F2013%2F11%2Fnews_detail_001972.jsp&mid=WC0b01ac058004d5c1 |date=2013-12-03 }} November 22, 2013. 11. ^{{cite journal|vauthors=Daniel F, Seksik P, Cacheux W, Jian R, Marteau P |title=Tolerance of 4-aminosalicylic acid enemas in patients with inflammatory bowel disease and 5-aminosalicylic-induced acute pancreatitis|journal=Inflamm Bowel Dis|volume=10|issue=3|pages=258–260|pmid=15290921|doi=10.1097/00054725-200405000-00013|year=2004}} 12. ^{{Cite journal | last1 = Jiang | first1 = Y. M. | last2 = Mo | first2 = X. A. | last3 = Du | first3 = F. Q. | last4 = Fu | first4 = X. | last5 = Zhu | first5 = X. Y. | last6 = Gao | first6 = H. Y. | last7 = Xie | first7 = J. L. | last8 = Liao | first8 = F. 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A. | last3 = Mitchison | first3 = D. A. | title = Studies on the treatment of tuberculosis undertaken by the British Medical Research Council tuberculosis units, 1946-1986, with relevant subsequent publications | journal = The International Journal of Tuberculosis and Lung Disease | volume = 3 | issue = 10 Suppl 2 | pages = S231–S279 | year = 1999 | pmid = 10529902}} External links
7 : Tuberculosis|Antibiotics|World Health Organization essential medicines|Anilines|Salicylic acids|RTT|Antimetabolites |
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