- References
| Name = 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase
| EC_number = 1.2.1.45
| CAS_number = 67272-39-3
| IUBMB_EC_number = 1/2/1/45
| GO_code = 0050606
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In enzymology, a 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase ({{EC number|1.2.1.45}}) is an enzyme that catalyzes the chemical reaction
4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + NADP+ + H2O4-carboxy-2-hydroxy-cis,cis-muconate + NADPH + 2 H+
The 3 substrates of this enzyme are 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde, NADP+, and H2O, whereas its 3 products are 4-carboxy-2-hydroxy-cis,cis-muconate, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP+ 6-oxidoreductase. Other names in common use include 2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase, 2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase, 4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP+, oxidoreductase, alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde, and dehydrogenase. This enzyme participates in tyrosine metabolism and benzoate degradation via hydroxylation.
References
- {{cite journal | vauthors = Maruyama K, Ariga N, Tsuda M, Deguchi K | location = Tokyo | title = Purification and properties of alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase | journal = J. Biochem. |date=April 1978 |volume=83 | pages = 1125–34 | pmid = 26671 | issue = 4 }}