“4-carboxymuconolactone decarboxylase”的意思、由来-开放百科全书

词条

4-carboxymuconolactone decarboxylase

释义

Structural studies
References

{{enzyme
| Name = 4-carboxymuconolactone decarboxylase
| EC_number = 4.1.1.44
| CAS_number = 37289-46-6
| IUBMB_EC_number = 4/1/1/44
| GO_code = 0047575
| image =
| width =
| caption =
}}

In enzymology, a 4-carboxymuconolactone decarboxylase ({{EC number|4.1.1.44}}) is an enzyme that catalyzes the chemical reaction

2-carboxy-2,5-dihydro-5-oxofuran-2-acetate 4,5-dihydro-5-oxofuran-2-acetate + CO₂

Hence, this enzyme has one substrate, 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate, and two products, 4,5-dihydro-5-oxofuran-2-acetate and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate carboxy-lyase (4,5-dihydro-5-oxofuran-2-acetate-forming). Other names in common use include gamma-4-carboxymuconolactone decarboxylase, and 4-carboxymuconolactone carboxy-lyase. This enzyme participates in benzoate degradation via hydroxylation.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code {{PDB link|2AF7}}.

References

{{cite journal | vauthors = Ornston LN | title = The conversion of catechol and protocatechuate to beta-ketoadipate by Pseudomonas putida. 3. Enzymes of the catechol pathway | journal = The Journal of Biological Chemistry | volume = 241 | issue = 16 | pages = 3795–9 | date = August 1966 | pmid = 5330966 }}
{{cite journal | vauthors = Ornston LN | date = 1970 | title = Conversion of catechol and protocatechuate to beta-ketoadipate (Pseudomonas putida) | journal = Methods Enzymol. | volume = 17A | pages = 529–549 | doi=10.1016/0076-6879(71)17237-0}}

2 : EC 4.1.1|Enzymes of known structure

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