KHSI may refer to:

• Hastings Municipal Airport (ICAO code KHSI)
• KHSI-LP, a low-power radio station (97.5 FM) licensed to serve Conrad, Montana, United States

• John Sotherton
• John's Other Wife
• John Soule
• John Southby (1594-1683)
• John Southcote
• John Southcote II
• John Southwood Jennings
• John Southworth (MP)
• John Southworth Ritter
• John Souttar McKendrick
• John S. Owen
• John S. Oyer
• John S. Palmore
• John S. Parker
• John S. Parkinson
• John Sparks (rugby league)
• John Sparnon
• John Sparrow (translator)
• John Spaulding (disambiguation)
• John Spaulding (Vermont Treasurer)
• John S. Peddie
• John Speke (1442-1518)
• John Spelman (judge)
• John Spence (footballer)
• John Spencer (15th century MP)