“5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase”的意思、由来-开放百科全书

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5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase

释义

Nomenclature
References
Further reading

{{enzyme
| Name = 5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase
| EC_number = 1.14.13.96
| CAS_number =
| IUBMB_EC_number = 1/14/13/96
| GO_code =
| image =
| width =
| caption =
}}

In enzymology, a 5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase ({{EC number|1.14.13.96}}) is an enzyme that catalyzes the chemical reaction

5beta-cholestane-3alpha,7alpha-diol + NADPH + H⁺ + O₂ 5beta-cholestane-3alpha,7alpha,12alpha-triol + NADP⁺ + H₂O

The 4 substrates of this enzyme are 5beta-cholestane-3alpha,7alpha-diol, NADPH, H⁺, and O₂, whereas its 3 products are 5beta-cholestane-3alpha,7alpha,12alpha-triol, NADP⁺, and H₂O.

Nomenclature

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is 5beta-cholestane-3alpha,7alpha-diol,NADPH:oxygen oxidoreductase (12alpha-hydroxylating). Other names in common use include 5beta-cholestane-3alpha,7alpha-diol 12alpha-monooxygenase, sterol 12alpha-hydroxylase (ambiguous), CYP8B1, and cytochrome P450 8B1.

References

{{cite journal | vauthors = Hansson R, Wikvall K | title = Hydroxylations in biosynthesis of bile acids. Cytochrome P-450 LM4 and 12alpha-hydroxylation of 5beta-cholestane-3alpha, 7alpha-diol | journal = European Journal of Biochemistry | volume = 125 | issue = 2 | pages = 423–9 | date = July 1982 | pmid = 6811268 | doi = 10.1111/j.1432-1033.1982.tb06700.x }}
{{cite journal | vauthors = Hansson R, Wikvall K | title = Hydroxylations in biosynthesis and metabolism of bile acids. Catalytic properties of different forms of cytochrome P-450 | journal = The Journal of Biological Chemistry | volume = 255 | issue = 4 | pages = 1643–9 | date = February 1980 | pmid = 6766451 }}
{{cite journal | vauthors = Lundell K, Wikvall K | title = Gene structure of pig sterol 12alpha-hydroxylase (CYP8B1) and expression in fetal liver: comparison with expression of taurochenodeoxycholic acid 6alpha-hydroxylase (CYP4A21) | journal = Biochimica et Biophysica Acta | volume = 1634 | issue = 3 | pages = 86–96 | date = November 2003 | pmid = 14643796 | doi = 10.1016/j.bbalip.2003.09.002 }}
{{cite journal | vauthors = Lukacin R, Matern U, Junghanns KT, Heskamp ML, Britsch L, Forkmann G, Martens S | title = Purification and antigenicity of flavone synthase I from irradiated parsley cells | journal = Archives of Biochemistry and Biophysics | volume = 393 | issue = 1 | pages = 177–83 | date = September 2001 | pmid = 11516175 | doi = 10.1006/abbi.2001.2491 }}
{{cite journal | vauthors = Yang Y, Zhang M, Eggertsen G, Chiang JY | title = On the mechanism of bile acid inhibition of rat sterol 12alpha-hydroxylase gene (CYP8B1) transcription: roles of alpha-fetoprotein transcription factor and hepatocyte nuclear factor 4alpha | journal = Biochimica et Biophysica Acta | volume = 1583 | issue = 1 | pages = 63–73 | date = June 2002 | pmid = 12069850 | doi = 10.1016/s1388-1981(02)00186-5 }}
{{cite journal | vauthors = Russell DW | title = The enzymes, regulation, and genetics of bile acid synthesis | journal = Annual Review of Biochemistry | volume = 72 | issue = 1 | pages = 137–74 | date = 2003 | pmid = 12543708 | doi = 10.1146/annurev.biochem.72.121801.161712 }}

3 : EC 1.14.13|NADPH-dependent enzymes|Enzymes of unknown structure

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Nomenclature

References

Further reading