KRLS may refer to:

• KRLS (FM), a radio station (92.1 FM) licensed to serve Knoxville, Iowa, United States
• Kinchafoonee Regional Library System

• Eastern Football Conference (1997-2000)
• Eastern Football Conference (1997–2000)
• Eastern four-nerve daisy
• Eastern fournerved daisy
• Eastern foxsnake
• Eastern foxtail-lily hawkmoth
• Eastern free-tailed bat
• Eastern fringed catchfly
• Eastern frogfish
• Eastern Frontal Fault System
• Eastern Front of the RSFSR
• Eastern Front (RSFSR)
• Eastern Front (Russian Civil War)
• Eastern Front (World War Two)
• Eastern Gaels
• Eastern Gaels GAA
• Eastern Gaels GFC
• Eastern gamagrass
• Eastern Garter Snake
• Eastern Gas Board
• Eastern Gas Pipeline
• Eastern gate of Philippopolis
• Eastern gate of Philippopolis (Plovdiv)
• Eastern General Hospital
• Eastern Ghazni