“6β-Hydroxyhyoscyamine epoxidase”的意思、由来-开放百科全书

词条

6β-Hydroxyhyoscyamine epoxidase

释义

Nomenclature
References

{{enzyme
| Name = 6β-Hydroxyhyoscyamine epoxidase
| EC_number = 1.14.11.14
| CAS_number = 121479-53-6
| IUBMB_EC_number = 1/14/11/14
| GO_code = 0047594
| image =
| width =
| caption =
}}

In enzymology, a 6β-hydroxyhyoscyamine epoxidase ({{EC number|1.14.11.14}}) is an enzyme that catalyzes the chemical reaction

(6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O₂ scopolamine + succinate + CO₂ + H₂O

The 3 substrates of this enzyme are (6S)-6-hydroxyhyoscyamine, 2-oxoglutarate, and O₂, whereas its 4 products are scopolamine, succinate, CO₂, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O₂ as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O₂ with 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor. This enzyme participates in alkaloid biosynthesis ii. It has two cofactors: iron and ascorbate.

Nomenclature

The systematic name of this enzyme class is (6S)-6-hydroxyhyoscyamine,2-oxoglutarate oxidoreductase (epoxide-forming). This enzyme is also called hydroxyhyoscyamine dioxygenase.

References

{{cite journal |vauthors=Hashimoto T, Kohno J, Yamada Y | date = 1989 | title = 6β-Hydroxyhyoscyamine epoxidase from cultured roots of Hyoscyamus niger | journal = Phytochemistry | volume = 28 | issue = 4 | pages = 1077–1082 | doi = 10.1016/0031-9422(89)80186-4 }}

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4 : EC 1.14.11|Iron enzymes|Ascorbate enzymes|Enzymes of unknown structure

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