| 释义 |
- Function
- References
- Further reading
{{Infobox_gene}}Lactate dehydrogenase B is a protein that in humans is encoded by the LDHB gene. [1]FunctionThis gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on chromosomes X, 5 and 13. References 1. ^{{cite web| title = Entrez Gene: Lactate dehydrogenase B| url = https://www.ncbi.nlm.nih.gov/gene/3945| accessdate = 2017-10-01}}
Further reading {{refbegin | 2}}- {{cite journal |vauthors=Philibert RA, Nelson JJ, Sandhu HK, Crowe RR, Coryell WH |title=Association of an exonic LDHA polymorphism with altered respiratory response in probands at high risk for panic disorder |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=117B |issue=1 |pages=11–7 |year=2003 |pmid=12555229 |doi=10.1002/ajmg.b.10015 |url=}}
- {{cite journal |vauthors=Mazzotta S, Guerranti R, Gozzetti A, Bucalossi A, Bocchia M, Sammassimo S, Petralia S, Ogueli GI, Lauria F |title=Increased serum lactate dehydrogenase isoenzymes in Ph-negative chronic myeloproliferative diseases: a metabolic adaptation? |journal=Hematology |volume=11 |issue=4 |pages=239–44 |year=2006 |pmid=17178662 |doi=10.1080/10245330600774835 |url=}}
- {{cite journal |vauthors=de Haas T, Hasselt N, Troost D, Caron H, Popovic M, Zadravec-Zaletel L, Grajkowska W, Perek M, Osterheld MC, Ellison D, Baas F, Versteeg R, Kool M |title=Molecular risk stratification of medulloblastoma patients based on immunohistochemical analysis of MYC, LDHB, and CCNB1 expression |journal=Clin. Cancer Res. |volume=14 |issue=13 |pages=4154–60 |year=2008 |pmid=18593994 |doi=10.1158/1078-0432.CCR-07-4159 |url=}}
- {{cite journal |vauthors=Whyte MP, Kempa LG, McAlister WH, Zhang F, Mumm S, Wenkert D |title=Elevated serum lactate dehydrogenase isoenzymes and aspartate transaminase distinguish Albers-Schönberg disease (Chloride Channel 7 Deficiency Osteopetrosis) among the sclerosing bone disorders |journal=J. Bone Miner. Res. |volume=25 |issue=11 |pages=2515–26 |year=2010 |pmid=20499337 |doi=10.1002/jbmr.130 |url=}}
- {{cite journal |vauthors=Egberts F, Momkvist A, Egberts JH, Kaehler KC, Hauschild A |title=Serum S100B and LDH are not useful in predicting the sentinel node status in melanoma patients |journal=Anticancer Res. |volume=30 |issue=5 |pages=1799–805 |year=2010 |pmid=20592382 |doi= |url=}}
- {{cite journal |vauthors=Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ |title=Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression |journal=PLoS ONE |volume=5 |issue=9 |pages=e12862 |year=2010 |pmid=20877624 |pmc=2943476 |doi=10.1371/journal.pone.0012862 |url=}}
- {{cite journal |vauthors=Swiderek K, Paneth P |title=Differences and similarities in binding of pyruvate and L-lactate in the active site of M4 and H4 isoforms of human lactate dehydrogenase |journal=Arch. Biochem. Biophys. |volume=505 |issue=1 |pages=33–41 |year=2011 |pmid=20951115 |doi=10.1016/j.abb.2010.10.010 |url=}}
- {{cite journal |vauthors=Zha X, Wang F, Wang Y, He S, Jing Y, Wu X, Zhang H |title=Lactate dehydrogenase B is critical for hyperactive mTOR-mediated tumorigenesis |journal=Cancer Res. |volume=71 |issue=1 |pages=13–8 |year=2011 |pmid=21199794 |doi=10.1158/0008-5472.CAN-10-1668 |url=}}
- {{cite journal |vauthors=Kim JH, Kim EL, Lee YK, Park CB, Kim BW, Wang HJ, Yoon CH, Lee SJ, Yoon G |title=Decreased lactate dehydrogenase B expression enhances claudin 1-mediated hepatoma cell invasiveness via mitochondrial defects |journal=Exp. Cell Res. |volume=317 |issue=8 |pages=1108–18 |year=2011 |pmid=21356207 |doi=10.1016/j.yexcr.2011.02.011 |url=}}
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