“7beta-hydroxysteroid dehydrogenase (NADP+)”的意思、由来-开放百科全书

词条

7beta-hydroxysteroid dehydrogenase (NADP+)

释义

References

{{DISPLAYTITLE:7beta-hydroxysteroid dehydrogenase (NADP⁺)}}{{enzyme
| Name = 7-beta-hydroxysteroid dehydrogenase (NADP⁺)
| EC_number = 1.1.1.201
| CAS_number = 79393-83-2
| IUBMB_EC_number = 1/1/1/201
| GO_code = 0047022
| image =https://cdn.rcsb.org/images/rutgers/fy/5fyd/5fyd.pdb-500.jpg
| width =
| caption =PDB entry 5FYD
|name=7-beta-hydroxysteroid dehydrogenase}}

In enzymology, a 7beta-hydroxysteroid dehydrogenase (NADP⁺) ({{EC number|1.1.1.201}}) is an enzyme that catalyzes the chemical reaction

a 7beta-hydroxysteroid + NADP⁺ a 7-oxosteroid + NADPH + H⁺

Thus, the two substrates of this enzyme are 7beta-hydroxysteroid and NADP⁺, whereas its 3 products are 7-oxosteroid, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 7beta-hydroxysteroid:NADP⁺ 7-oxidoreductase. Other names in common use include NADP⁺-dependent 7beta-hydroxysteroid dehydrogenase, and 7beta-hydroxysteroid dehydrogenase (NADP⁺).

References

{{cite journal | vauthors = Savino S, Ferrandi EE, Forneris F, Rovida S, Riva S, Monti D, Mattevi A | title = Structural and biochemical insights into 7β-hydroxysteroid dehydrogenase stereoselectivity | journal = Proteins | volume = 84 | issue = 6 | pages = 859–65 | date = June 2016 | pmid = 27006087 | doi = 10.1002/prot.25036 }}
{{cite journal | vauthors = Hirano S, Masuda N | title = Characterization of NADP-dependent 7 beta-hydroxysteroid dehydrogenases from Peptostreptococcus productus and Eubacterium aerofaciens | journal = Applied and Environmental Microbiology | volume = 43 | issue = 5 | pages = 1057–63 | date = May 1982 | pmid = 6954878 | pmc = 244185 }}
{{cite journal | vauthors = MacDonald IA, Roach PD | title = Bile induction of 7 alpha- and 7 beta-hydroxysteroid dehydrogenases in Clostridium absonum | journal = Biochimica et Biophysica Acta | volume = 665 | issue = 2 | pages = 262–9 | date = August 1981 | pmid = 6945134 | doi = 10.1016/0005-2760(81)90011-4 }}
{{cite journal | vauthors = MacDonald IA, Rochon YP, Hutchison DM, Holdeman LV | title = Formation of ursodeoxycholic acid from chenodeoxycholic acid by a 7 beta-hydroxysteroid dehydrogenase-elaborating Eubacterium aerofaciens strain cocultured with 7 alpha-hydroxysteroid dehydrogenase-elaborating organisms | journal = Applied and Environmental Microbiology | volume = 44 | issue = 5 | pages = 1187–95 | date = November 1982 | pmid = 6758698 | pmc = 242167 }}

3 : EC 1.1.1|NADPH-dependent enzymes|Enzymes of unknown structure

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