| 词条 | 8-Aminoquinoline |
| 释义 |
| verifiedrevid = 477226908 | ImageFile = 8-aminoquinoline.svg | ImageSize = 150px | ImageAlt = | IUPACName = Quinolin-8-amine | OtherNames = | Section1 = {{Chembox Identifiers | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 10881 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C9H8N2/c10-8-5-1-3-7-4-2-6-11-9(7)8/h1-6H,10H2 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = WREVVZMUNPAPOV-UHFFFAOYSA-N | CASNo =578-66-5 | CASNo_Ref = {{cascite|correct|CAS}} | PubChem = 11359 | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 99932 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = U34EAV21TG | SMILES = Nc1cccc2cccnc12 }} | Section2 = {{Chembox Properties | C = 9 | H = 8 | N = 2 | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = }} | Section3 = {{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }} }} 8-Aminoquinoline is a form of aminoquinoline with an amine at the 8-position of quinoline. The 8-aminoquinoline family of drugs contains three members, primaquine, tafenoquine and pamaquine[1] and are used in the treatment of malaria. They may be used to eradicate malaria hypnozoites from the liver and have both been used for malaria prophylaxis. The 8-aminoquinoline drugs must not be given to patients with G6PD deficiency, because they cause potentially fatal haemolysis in these patients. Pamaquine is no longer available anywhere, but primaquine is still used routinely worldwide as part of the treatment of Plasmodium vivax and Plasmodium ovale malaria. Tafenoquine is currently in Phase III clinical trials and is not yet available to prescribe. AgentsReferences1. ^{{cite journal | title=Short report: The activity of pamaquine, an 8-aminoquinoline drug, against sporozoite-induced infections of Plasmodium vivax (New Guinea strains) | author=Sweeney AW | author2=Blackburn CRB | author3=KH Rieckmann | journal=Am J Trop Med Hyg | volume=71 | issue=2 | date=1 August 2004| pages=187–189 | url=http://www.ajtmh.org/cgi/content/full/71/2/187 | pmid=15306708 }} {{Antimalarials}}{{DEFAULTSORT:Aminoquinoline, 8-}}{{antimicrobial-stub}} 3 : Abandoned drugs|Antimalarial agents|Quinolines |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。