| 词条 | 8-OH-DPAT |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 477227247 | ImageFile = 8-OH-DPAT.svg | ImageFile_Ref = {{chemboximage|correct|??}} | ImageSize = 244 | ImageName = Kekulé, skeletal formula of 8-OH-DPAT | SystematicName = 7-(Dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol[1] |Section1={{Chembox Identifiers | Abbreviations = 8-OH-DPAT | CASNo_Ref = {{cascite|changed|??}} | CASNo = 78950-78-4 | PubChem = 1220 | PubChem1 = 6603866 | PubChem1_Comment = (R) | PubChem2 = 10125797 | PubChem2_Comment = (S) | ChemSpiderID = 1183 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID1 = 5036174 | ChemSpiderID1_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID1_Comment = (R) | ChemSpiderID2 = 8301316 | ChemSpiderID2_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID2_Comment = (S) | ChEBI_Ref = {{ebicite|changed|EBI}} | ChEBI = 73364 | MeSHName = 8-Hydroxy-2-(di-n-propylamino)tetralin | ChEMBL = 56 | ChEMBL_Ref = {{ebicite|correct|EBI}} | IUPHAR_ligand = 7 | SMILES = CCCN(CCC)C1CCc2cccc(O)c2C1 | SMILES1 = CCCN(CCC)C1CCC2=C(C1)C(O)=CC=C2 | StdInChI = 1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | InChI = 1/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3 | StdInChIKey = ASXGJMSKWNBENU-UHFFFAOYSA-N | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | InChIKey = ASXGJMSKWNBENU-UHFFFAOYAY }} |Section2={{Chembox Properties | C=16 | H=25 | N=1 | O=1 | LogP = 3.711 | pKa = 10.539 | pKb = 3.458 }} |Section3={{Chembox Pharmacology | HalfLife = 1.5 hours }} }} 8-OH-DPAT is a research chemical of the aminotetralin chemical class which was developed in the 1980s and has been widely used to study the function of the 5-HT1A receptor. It was one of the first major 5-HT1A receptor full agonists to be discovered. Originally believed to be selective for the 5-HT1A receptor, 8-OH-DPAT was later found to act as a 5-HT7 receptor agonist and serotonin reuptake inhibitor/releasing agent as well.[2][3][4][5][6] In animal studies, 8-OH-DPAT has been shown to possess antidepressant,[7] anxiolytic,[8] serenic,[9] anorectic,[10] antiemetic,[11] hypothermic,[12] hypotensive,[13] bradycardic,[13] hyperventilative,[14][15][16] and analgesic effects.[17] See also
References1. ^{{Cite web|url = https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=1220|title = 8-hydroxy-2-(di-n-propylamino)tetralin - PubChem Public Chemical Database|work = The PubChem Project|location = USA|publisher = National Center for Biotechnology Information}} 2. ^{{cite journal | author = Larsson LG | author2 = Rényi L | author3 = Ross SB | author4 = Svensson B | author5 = Angeby-Möller K | title = Different effects on the responses of functional pre- and postsynaptic 5-HT1A receptors by repeated treatment of rats with the 5-HT1A receptor agonist 8-OH-DPAT | journal = Neuropharmacology | volume = 29 | issue = 2 | pages = 85–91 |date=February 1990 | pmid = 1691832 | doi = 10.1016/0028-3908(90)90047-U| url = }} 3. ^{{cite journal | author = Sprouse J | author2 = Reynolds L | author3 = Li X | author4 = Braselton J | author5 = Schmidt A | title = 8-OH-DPAT as a 5-HT7 agonist: phase shifts of the circadian biological clock through increases in cAMP production | journal = Neuropharmacology | volume = 46 | issue = 1 | pages = 52–62 |date=January 2004 | pmid = 14654097 | doi = 10.1016/j.neuropharm.2003.08.007| url = http://linkinghub.elsevier.com/retrieve/pii/S0028390803003472}} 4. ^{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2337 | title = IUPHAR DATABASE - 5-Hydroxytryptamine receptors - 5-HT7}} 5. ^{{cite journal | author = Assié MB | author2 = Koek W | title = Possible in vivo 5-HT reuptake blocking properties of 8-OH-DPAT assessed by measuring hippocampal extracellular 5-HT using microdialysis in rats | journal = British Journal of Pharmacology | volume = 119 | issue = 5 | pages = 845–50 |date=November 1996 | pmid = 8922730 | pmc = 1915946 | doi = 10.1111/j.1476-5381.1996.tb15749.x| url = }} 6. ^{{cite journal | author = Wölfel R | author2 = Graefe KH | title = Evidence for various tryptamines and related compounds acting as substrates of the platelet 5-hydroxytryptamine transporter | journal = Naunyn-Schmiedeberg's Archives of Pharmacology | volume = 345 | issue = 2 | pages = 129–36 |date=February 1992 | pmid = 1570019 | doi = 10.1007/BF00165727| url = }} 7. ^{{cite journal | author = Luscombe GP | author2 = Martin KF | author3 = Hutchins LJ | author4 = Gosden J | author5 = Heal DJ | title = Mediation of the antidepressant-like effect of 8-OH-DPAT in mice by postsynaptic 5-HT1A receptors | journal = British Journal of Pharmacology | volume = 108 | issue = 3 | pages = 669–77 |date=March 1993 | pmid = 8467355 | pmc = 1908013 | doi = 10.1111/j.1476-5381.1993.tb12859.x| url = }} 8. ^{{cite journal | author = Schreiber R | author2 = De Vry J | title = Neuronal circuits involved in the anxiolytic effects of the 5-HT1A receptor agonists 8-OH-DPAT ipsapirone and buspirone in the rat | journal = European Journal of Pharmacology | volume = 249 | issue = 3 | pages = 341–51 |date=November 1993 | pmid = 7904566 | doi = 10.1016/0014-2999(93)90531-L| url = }} 9. ^{{cite journal | author = de Boer SF | author2 = Koolhaas JM | title = 5-HT1A and 5-HT1B receptor agonists and aggression: a pharmacological challenge of the serotonin deficiency hypothesis | journal = European Journal of Pharmacology | volume = 526 | issue = 1–3 | pages = 125–39 |date=December 2005 | pmid = 16310183 | doi = 10.1016/j.ejphar.2005.09.065 | url = }} 10. ^{{cite journal | author = Dourish CT | author2 = Hutson PH | author3 = Curzon G | title = Characteristics of feeding induced by the serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) | journal = Brain Research Bulletin | volume = 15 | issue = 4 | pages = 377–84 |date=October 1985 | pmid = 2933126 | doi = 10.1016/0361-9230(85)90005-X| url = http://linkinghub.elsevier.com/retrieve/pii/0361-9230(85)90005-X}} 11. ^{{cite journal | author = Lucot JB | title = Antiemetic effects of flesinoxan in cats: comparisons with 8-hydroxy-2-(di-n-propylamino)tetralin | journal = European Journal of Pharmacology | volume = 253 | issue = 1–2 | pages = 53–60 |date=February 1994 | pmid = 8013549 | doi = 10.1016/0014-2999(94)90756-0| url = }} 12. ^{{cite journal | author = O'Connell MT | author2 = Sarna GS | author3 = Curzon G | title = Evidence for postsynaptic mediation of the hypothermic effect of 5-HT1A receptor activation | journal = British Journal of Pharmacology | volume = 106 | issue = 3 | pages = 603–9 |date=July 1992 | pmid = 1387027 | pmc = 1907559 | doi = 10.1111/j.1476-5381.1992.tb14382.x| url = }} 13. ^1 {{cite journal | author = Fozard JR | author2 = Mir AK | author3 = Middlemiss DN | title = Cardiovascular response to 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) in the rat: site of action and pharmacological analysis | journal = Journal of Cardiovascular Pharmacology | volume = 9 | issue = 3 | pages = 328–47 |date=March 1987 | pmid = 2437400 | doi = 10.1097/00005344-198703000-00010| url = }} 14. ^{{cite journal |author =Sahibzada N |author2 =Ferreira M |author3 =Wasserman AM |author4 =Taveira-DaSilva AM |author5 =Gillis RA |title=Reversal of morphine-induced apnea in the anesthetized rat by drugs that activate 5-hydroxytryptamine(1A) receptors |journal=The Journal of Pharmacology and Experimental Therapeutics |volume=292 |issue=2 |pages=704–13 |date=February 2000 |pmid=10640309 |doi= |url=}} 15. ^{{cite journal | author = Meyer LC | author2 = Fuller A | author3 = Mitchell D | title = Zacopride and 8-OH-DPAT reverse opioid-induced respiratory depression and hypoxia but not catatonic immobilization in goats | journal = American Journal of Physiology. Regulatory, Integrative and Comparative Physiology | volume = 290 | issue = 2 | pages = R405–13 |date=February 2006 | pmid = 16166206 | doi = 10.1152/ajpregu.00440.2005 | url = }} 16. ^{{cite journal |author =Guenther U |author2 =Manzke T |author3 =Wrigge H |author4 =Dutschmann M |author5 =Zinserling J |author6 =Putensen C |author7 =Hoeft A |title=The counteraction of opioid-induced ventilatory depression by the serotonin 1A-agonist 8-OH-DPAT does not antagonize antinociception in rats in situ and in vivo |journal=Anesthesia and Analgesia |volume=108 |issue=4 |pages=1169–76 |date=April 2009 |pmid=19299781 |doi=10.1213/ane.0b013e318198f828 |url=}} 17. ^{{cite journal | author = Xu W | author2 = Qiu XC | author3 = Han JS | title = Serotonin receptor subtypes in spinal antinociception in the rat | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 269 | issue = 3 | pages = 1182–9 |date=June 1994 | pmid = 8014862 | doi = | url = http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=8014862}} External links
5 : Serotonin receptor agonists|Serotonin reuptake inhibitors|Serotonin releasing agents|Phenols|Tetralins |
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