| Diplomatic agrément/Diplomatic accreditation | ambassador | Observations | List of Presidents of Uruguay | List of Presidents of Chile | Term end | | 1871 | } | José Arrieta|es}} | Lorenzo Batlle y Grau | Federico Errázuriz Zañartu |
| 1883 | } | José Arrieta|es}} | Máximo Santos | Domingo Santa María González |
| 1909 | } | Juan Lindolfo de los Reyes Cuestas York (1837 – 1905) | Claudio Williman | Pedro Montt Montt |
| 1916 | } | Manuel B. Otero | Feliciano Viera | Juan Luis Sanfuentes Andonaegui |
| 1918 | } | Dionisio Ramos Montero | Feliciano Viera | Juan Luis Sanfuentes Andonaegui |
| 1921 | } | Eugenio Martínez Thedy | (* August 8, 1885 in Salto, Uruguay) Minister plenipotentiary to Chile, 1920-1934. Delegate, Pan American Conference, Santiago de Chile, 1923, Lima, 1938, Chaco peace conference, 1936, Interamerican Conference for Maintenance of Peace, Buenos Aires, 1936. Acting minister of interior, 1934. Uruguayan ambassador to Argentina, 1934. 1948: Uruguayan ambassador to Peru. | Baltasar Brum | Arturo Alessandri Palma | 1924 | } |
| 1935 | } | Luis Enrique Azarola Gil | (* 1882) | Gabriel Terra | Carlos Dávila |
| 1936 | } | Carlos María de Santiago|es}} | Gabriel Terra | Carlos Dávila |
| 1942 | } | Hugo V. De Pena | Alfredo Baldomir | Juan Antonio Ríos Morales |
| 1957 | } | José G. Lissidini | Alberto Fermín Zubiría | Carlos Ibáñez del Campo |
| 1960 | } | Álvaro R. Vázquez | Benito Nardone | Jorge Alessandri Rodríguez |
| 1963 | } | Julio César Vignale | Daniel Fernández Crespo | Jorge Alessandri Rodríguez |
| 1969 | } | Aireliano Aguirre | Jorge Pacheco Areco | Eduardo Frei Montalva |
| 1970 | } | Manuel Sánchez Morales | Jorge Pacheco Areco | Salvador Allende Gossens |
| 1973 | } | Roberto González Casal | Juan María Bordaberry | Augusto Pinochet Ugarte |
| 1978 | } | Dante Paladini Mainenti | Aparicio Méndez | Augusto Pinochet Ugarte |
| 1982 | } | Julio César Lupinacci Gabriel | Gregorio Álvarez | Augusto Pinochet Ugarte |
| 1985 | } | Alfredo Bianchi Palazzo | Julio María Sanguinetti | Augusto Pinochet Ugarte |
| 1986 | } | Nicolás Moreno | Julio María Sanguinetti | Augusto Pinochet Ugarte |
| 1990 | } | José María Alzamora da Cámara Canto | Luis Alberto Lacalle Herrera | Patricio Aylwin Azócar |
| 1994 | } | Juan Bautista Oddone Silveira | Luis Alberto Lacalle | Eduardo Frei Ruiz-Tagle |
| 2000 | } | Alejandro Lorenzo y Losada | Jorge Batlle Ibáñez | Ricardo Lagos Escobar |
| 2005 | } | Carlos Pita (politician) | Tabaré Vázquez | Ricardo Lagos Escobar | 2010|03|01}} |
| 2010|03|01}} | Pedro Vaz (diplomat) | José Mujica | Sebastián Piñera | 2012|12|06}} |
| 2013|05|01}} | Rodolfo Camarosano Bersani|de}} | José Mujica | Sebastián Piñera | 2018|06|25}} |
| 2018|06|25}} | Alberto Leopoldo Fajardo Klappenbach|de}} | Tabaré Vázquez | Sebastián Piñera |
{{coord|-33.429187|-70.610411|display=title|region:BO_type:landmark}}1. ^[https://legislativo.parlamento.gub.uy/temporales/aresuelveref.aspx?REPARTIDO,S/2018/08/0687/00//PDF embajador uruguayo en Santiago de Chile]