| 释义 |
- See also
This is a list of cytochrome P450 modulators, or inhibitors and inducers of cytochrome P450 enzymes. | Enzyme | Inhibitors | Inducers |
|---|
CYP1A1- Certain foods (e.g., cumin, turmeric)
- Certain herbs/herbal teas (e.g., peppermint, German chamomile, dandelion)
- Amiodarone
- Caffeine
- Cimetidine
- Echinacea
- Fluoroquinolones (e.g., ciprofloxacin)
- Fluvoxamine
- Interferon
- Isoniazid
- Methoxsalen
- Mibefradil
- Naringenin (grapefruit)
- Nilutamide
- St. John's wort
- Verapamil
- Certain foods (e.g., broccoli, cauliflower, brussels sprouts, chargrilled meat)
- Insulin
- Methylcholanthrene
- Modafinil
- Nafcillin
- Omeprazole
- Phenytoin
- beta-Naphthoflavone
- Tobacco
|
|---|
CYP2A6- Amiodarone
- Amlodipine
- Buprenorphine
- Clofibrate
- Clotrimazole
- Desipramine
- Disulfiram
- Entacapone
- Fenofibrate
- Flavonoids (grapefruit)
- Gabapentin
- Isoniazid
- Ketoconazole
- Letrozole
- Methimazole
- Methoxsalen
- Metyrapone
- Miconazole
- Modafinil
- Nicotine
- Orphenadrine
- Pilocarpine
- Pregabalin
- Selegiline
- Sulconazole
- Tioconazole
- Tranylcypromine
- Barbiturates (e.g., amobarbital, pentobarbital, phenobarbital, secobarbital)
- Rifampicin
|
|---|
CYP2B6- Curcumin (turmeric)
- Memantine
- Orphenadrine
- ThioTEPA
- Ticlopidine
- Carbamazepine
- Phenobarbital
- Phenytoin
- Rifampicin
|
|---|
CYP2C8- Gemfibrozil
- Montelukast
- Quercetin
- Thiazolidinediones
- Trimethoprim
|
|---|
CYP2C9- Amiodarone
- Apigenin
- Chloramphenicol
- Cimetidine
- Cyclizine
- Fenofibrate
- Flavonoids (e.g., amentoflavone (Ginkgo biloba, St. John’s Wort))
- Fluconazole
- Fluvastatin
- Fluvoxamine
- Isoniazid
- Lovastatin
- Miconazole
- Modafinil
- Nilutamide
- Phenylbutazone
- Probenecid
- Promethazine
- Quercetin
- Sertraline
- Sulfamethoxazole
- Sulfaphenazole
- Teniposide
- Valproic acid
- Voriconazole
- Zafirlukast
- Aprepitant
- Bosentan
- Enzalutamide
- Phenobarbital
- Phenytoin
- Rifampicin
- Secobarbital
- St. Johns Wort
|
|---|
CYP2C19- Chloramphenicol
- Cimetidine
- Felbamate
- Fluoxetine
- Fluvoxamine
- Indomethacin
- Isoniazid
- JWH-018
- Ketoconazole
- Moclobemide
- Modafinil
- Probenecid
- Proton pump inhibitors (e.g., lansoprazole, omeprazole, pantoprazole, rabeprazole)
- Ticlopidine
- Topiramate
- Artemisinin
- Aspirin
- Carbamazepine
- Enzalutamide
- Norethisterone
- Phenytoin
- Prednisone
- Rifampicin
|
|---|
CYP2D6- Amiodarone
- Buprenorphine
- Bupropion
- Cannabidiol
- Celecoxib
- Chlorphenamine
- Chlorpromazine
- Cimetidine
- Cinacalcet
- Citalopram
- Clemastine
- Clomipramine
- Cocaine
- Diphenhydramine
- Doxepin
- Doxorubicin
- Duloxetine
- Escitalopram
- Fluoxetine
- Halofantrine
- Haloperidol
- Hydroxyzine
- Hyperforin (St. Johns Wort)
- Levomepromazine
- Methadone
- Methylphenidate
- Metoclopramide
- Mibefradil
- Midodrine
- Moclobemide
- Niacin
- Nicotinamide
- Paroxetine
- Perphenazine
- Promethazine
- Quinidine
- Ranitidine
- Risperidone
- Ritonavir
- Sertraline
- Terbinafine
- Thioridazine
- Ticlopidine
- Tripelennamine
- Zuclopenthixol
- Dexamethasone
- Glutethimide
- Haloperidol
- Rifampicin
|
|---|
| CYP2E1 |
|---|
CYP3A4- Amiodarone
- Aprepitant
- Bergamottin (grapefruit)
- Buprenorphine
- Cafestol
- Chloramphenicol
- Cimetidine
- Ciprofloxacin
- Clarithromycin
- Cobicistat
- Delavirdine
- Diltiazem
- Dithiocarbamate
- Domperidone
- Erythromycin
- Fluconazole
- Fluvoxamine
- Gestodene
- Ginkgo biloba
- Imatinib
- Indinavir
- Isoniazid
- Itraconazole
- Ketoconazole
- Mibefradil
- Mifepristone
- Milk thistle
- Nefazodone
- Nelfinavir
- Niacinamide
- Nilutamide
- Norfloxacin
- Orphenadrine
- Piperine
- Quercetin
- Ranitidine
- Ritonavir
- Saquinavir
- Star fruit
- Telithromycin
- Valerian
- Valproic acid
- Verapamil
- Voriconazole
- Barbiturates (e.g., butalbital, phenobarbital)
- Capsaicin
- Carbamazepine
- Efavirenz
- Enzalutamide
- Glucocorticoids
- Modafinil
- Nevirapine
- Oxcarbazepine
- Phenytoin
- Pioglitazone
- Quercetin
- Rifabutin
- Rifampicin
- St. John's wort
- Topiramate
- Troglitazone
|
|---|
CYP4–51- See Prostanoid signaling modulators and Leukotriene signaling modulators instead for eicosanoid-specific CYP450s, including:
- CYP4F3 (leukotriene-B4 ω-hydroxylase 2)
- CYP5A1 (thromboxane-A synthase)
- CYP8A1 (prostacyclin synthase)
- See the list of steroid metabolism modulators instead for steroid/sterol-specific CYP450s, including:
- CYP7A1 (cholesterol 7α-hydroxylase)
- CYP7B1 (25-hydroxycholesterol 7α-hydroxylase)
- CYP8B1 (sterol 12α-hydroxylase)
- CYP11A1 (cholesterol side-chain cleavage enzyme; P450scc)
- CYP11B1 (steroid 11β-hydroxylase)
- CYP11B2 (aldosterone synthase)
- CYP17A1 (steroid 17α-hydroxylase/17,20-lyase)
- CYP19A1 (aromatase)
- CYP21A2 (steroid 21-hydroxylase)
- CYP24A1 (1,25-dihydroxyvitamin D3 24-hydroxylase)
- CYP27A1 (sterol 27-hydroxylase)
- CYP27B1 (25-hydroxyvitamin D3 1α-hydroxylase)
- CYP39A1 (oxysterol 7α-hydroxylase 2)
- CYP46A1 (cholesterol 24-hydroxylase)
- CYP51A1 (lanosterol 14α-demethylase)
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See also- List of steroid metabolism modulators
1 : Drug-related lists |