| Name | Neighborhood | Type | Summary | | Campbell House Museum | Downtown West | Historic house | 1880s Victorian townhouse |
| Carondelet Historic Center | Carondelet | Local history | website, operated by the Carondelet Historical Society |
| Cathedral Basilica of Saint Louis | Central West End | Art | Church basement contains a museum dedicated to the mosaics in the church as well as some of the other artifacts found within the Cathedral |
| Center of Creative Arts | Delmar Loop | Art | Arts center with classes in performing arts and visual arts exhibition gallery[1] |
| Chatillon–DeMenil House | Benton Park | Historic house | 19th-century mansion, features a collection of memorabilia from the 1904 World's Fair |
| City Museum | Downtown West | Multiple | Eclectic mixture of children’s playground, funhouse, surrealistic pavilion, and an architectural marvel made out of found objects |
| Contemporary Art Museum St. Louis | Midtown | Art | Contemporary art |
| Craft Alliance Center of Art + Design | Delmar Loop | Art | Contemporary crafts education center with an exhibition gallery |
| Field House Museum | Downtown | Multiple | Historic home focusing on Roswell Field and Dred Scott, Eugene Field, and toys |
| The Griot Museum of Black History | St. Louis Place | African-American | Fife-size wax figures, art, artifacts and memorabilia to interpret the stories of important African Americans with a regional connection; formerly the Black World History Museum |
| HealthWorks! Kids' Museum St. Louis | Forest Park | Children's | website |
| Inside the Economy Museum | Downtown | Economics | [https://www.stlouisfed.org/inside-the-economy-museum website], operated by the Federal Reserve Bank of St. Louis, explains the economy and people's role in it |
| International Photography Hall of Fame and Museum | Midtown | Art | website, also known as IPHF, exhibits include history of photography, cameras and equipment, changing exhibits of historic and contemporary photography |
| Gateway Arch National Park | Downtown | History | Includes the Museum of Westward Expansion and Old Courthouse |
| Judicial Learning Center | Downtown | Economics | website, located in the Thomas F. Eagleton United States Courthouse, explains the function and value of the judicial branch of government, especially at the federal level |
| Lemp Neighborhood Arts Center | Benton Park | Art | Community arts center |
| Mildred Lane Kemper Art Museum | St. Louis | Art | Part of Washington University in St. Louis, collections include 19th, 20th, and 21st-century European and American paintings, sculptures, prints, installations, and photographs |
| Miniature Museum of Greater St. Louis | Bevo Mill | Toy | website, doll houses and miniatures |
| Missouri History Museum | Forest Park | History | Operated by the Missouri Historical Society |
| The MOTO Museum | Midtown | Transportation | [https://www.themotomuseum.com website], private collection of unique motorcycles obtained from over 20 countries |
| Museum of Contemporary Religious Art | Midtown | Art | Part of Saint Louis University, interfaith museum of contemporary art that engages religious and spiritual themes |
| National Blues Museum | Downtown | Music | Musical history and impact of the blues |
| Old Courthouse | Downtown | History | Part of Gateway Arch National Park, site of Dred Scott trial, houses dioramas of westward expansion and settlement of Missouri |
| Pulitzer Arts Foundation | Midtown | Art | Contemporary art, architecture and culture |
| Saint Louis Art Museum | Forest Park | Art | Collection includes art from around the world and many eras |
| Saint Louis University Museum of Art | Midtown | Art | Part of Saint Louis University, collections include modern art, Asian decorative arts, Jesuit and Catholic art and artifacts that reflect the frontier experience of the Jesuit missionaries |
| Samuel Cupples House | Midtown | Decorative arts | Part of Saint Louis University, historic house that serves as a gallery for the University's collection of fine and decorative art dating before 1919, McNamee Gallery hosts exhibitions of art by SLU students and faculty and visiting artists |
| Scott Joplin House State Historic Site | Midtown | Biographical | Home of composer Scott Joplin from 1900 to 1903 |
| The Sheldon | Midtown | Art | Concert hall and Sheldon Art Galleries |
| Soldiers' Memorial | Downtown West | Military | Military displays and memorabilia from World War I and subsequent American wars |
| St. Louis Soccer Hall of Fame | Southwest Garden | Sports | Soccer history from the St. Louis area, currently closed |
| St. Louis Union Station Memories Museum | Downtown West | Railroad | History of the historic railroad station and rail travel in the U.S. |
| St. Louis Cardinals Hall of Fame Museum | Downtown | Sports |
| St. Louis Science Center | Forest Park | Science | Features over 750 exhibits in a complex of over 300,000 square feet (28,000 m2) and a planetarium |
| World Aquarium | Downtown | Natural history |
| World Chess Hall of Fame | Central West End | History | Honors achievements in the game of chess |
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1. ^{{cite web|title=Official site|url=http://www.cocastl.org|publisher=Center of Creative Arts|accessdate=17 October 2017}}
2. ^{{cite web|url=http://www.southcountytimes.com/Articles-i-2008-08-08-79032.113117_Final_Goodbyes_For_CCC_Museum.html|title=Final Goodbyes For CCC Museum|author=Don Corrigan|work=South County Times}}
3. ^{{cite web|url=http://www.coinop.org/features/coinopmuseum/|title=Coinop.org /// Some Random Page|work=Coinop.org}}