Senators for Isère under the French Third Republic were:{{sfn|Liste des anciens sénateurs de la IIIème République}}
| Period | Name | Notes |
|---|
| 1876–1879 | Marc-Antoine Brillier |
| Joseph Eymard-Duvernay |
| François Michal-Ladichère |
| 1879–1888 | Joseph Eymard-Duvernay |
| François Michal-Ladichère | Died 16 October 1884 |
| Joseph Marion de Faverges | Replaced François Michal-Ladichère. |
| Abel-Antoine Ronjat | Resigned 25 November 1884 |
| Jean Couturier | Replaced Abel-Antoine Ronjat |
| 1888–1897 | Jean Couturier | Died 16 August 1894 |
| Mathias Saint-Romme | Replaced Jean Couturier |
| Joseph Marion de Faverges | Died 1 December 1890 |
| Léonce-Émile Durand-Savoyat | Replaced Joseph Marion de Faverges |
| Édouard Rey |
| 1897–1906 | Antonin Dubost |
| Léonce-Émile Durand-Savoyat | Died 17 May 1903 |
| Gustave Rivet | Replaced Léonce-Émile Durand-Savoyat |
| Édouard Rey | Died 3 April 1901 |
| Camille Jouffray | Replaced Édouard Rey |
| Mathias Saint-Romme | Replaced Antoine Théry, irremovable senator who died on 28 December 1896
Saint-Romme thus became the 4th senator of Isère. |
| 1906–1920 | Antonin Dubost |
| Camille Jouffray |
| Gustave Rivet |
| Mathias Saint-Romme |
| 1920–1924 | Antonin Dubost | Died 15 April 1921 |
| Claude Rajon | Replaced Antonin Dubost |
| Léon Perrier |
| Gustave Rivet |
| Joseph Vallier |
| 1924–1933 | Joseph Brenier |
| Léon Perrier |
| Claude Rajon | [Died 3 October 1932, not replaced |
| Joseph Vallier |
| 1933–1941 | Robert Belmont |
| Léon Perrier |
| Joseph Serlin |
| Joseph Vallier | Died 26 August 1935 |
| Joseph Paganon | Replaced Joseph Vallier
Died 2 November 1937 |
| Louis Guyonnet | Replaced Joseph Paganon |
Senators for Isère under the French Fourth Republic were:{{sfn|Liste des anciens sénateurs de la IVème République}}
Senators for Isère under the French Fifth Republic:{{sfn|Liste des anciens sénateurs de la Vème République}}{{sfn|Liste par département - Isère}}
| Period | Name | Party or group | Notes | | 1959–1965 | Jean Berthoin | Gauche démocratique (GD) |
| Jean-Baptiste Dufeu | Gauche démocratique (GD) |
| Paul Mistral | French Section of the Workers' International (SFIO) |
| 1965–1974 | Jean Berthoin | Gauche démocratique (GD) |
| Jean-Baptiste Dufeu | Gauche démocratique (GD) |
| Paul Mistral | Socialist Party (PS) |
| 1974–1983 | Paul Jargot | French Communist Party (PCF) |
| Paul Mistral | Socialist Party (PS) | Died 29 August 1981 |
| Raymond Espagnac | Replaced Paul Mistral |
| Pierre Perrin | none |
| 1983–1992 | Jean Boyer | Union for French Democracy (UDF)
Republican Party (PR) |
| Guy-Pierre Cabanel | Union for French Democracy (UDF)
Republican Party (PR) |
| Charles Descours | Rally for the Republic (RPR) |
| Jean Faure | Union for French Democracy (UDF)
Centre of Social Democrats (CDS) |
| 1992–2001 | Jean Boyer | Union for French Democracy (UDF)
Republican Party (PR) |
| Guy-Pierre Cabanel | Union for French Democracy (UDF)
Republican Party (PR) |
| Charles Descours | Rally for the Republic (RPR) |
| Jean Faure | Union for French Democracy (UDF)
Centre of Social Democrats (CDS) |
| 2001–2011 | Annie David | French Communist Party (PCF) |
| Jean Faure | Union for a Popular Movement (UMP) |
| Louis Mermaz | Socialist Party (PS) |
| Bernard Saugey | Union for a Popular Movement (UMP) |
| 2011–2017 | Jacques Chiron | Socialist Party (PS) |
| Annie David | French Communist Party (PCF) |
| Bernard Saugey | Union for a Popular Movement (UMP) |
| Michel Savin | Union for a Popular Movement (UMP) |
| André Vallini | Socialist Party (PS) | Named to cabinet in May 2014
Returned to senate June 2017 |
| Éliane Giraud | Socialist Party (PS) | Replaced André Vallini May 2014 to June 2017 |
| 2017–2023 | Didier Rambaud | La République En Marche! (REM) |
| Guillaume Gontard | Miscellaneous left (DVG) |
| Frédérique Puissat | The Republicans (LR) |
| Michel Savin | The Republicans (LR) |
| André Vallini | Socialist Party (PS) | 2011–2014, 2017 |