Player | Caps | Goals | First cap | Last cap | Honours | {{sortname|Diego|Godín}} | 126 | 8 | 2005 | 2019 | Copa América (2011) |
{{sortname|Maxi|Pereira}} | 125 | 3 | 2005 | 2018 | Copa América (2011) |
{{sortname|Diego|Forlan}} | 112 | 36 | 2002 | 2014 | Copa América (2011) |
{{sortname| Cristian|Rodríguez}} | 109 | 11 | 2003 | 2018 | Copa América (2011) |
{{sortname| Edinson | Cavani}} | 109 | 46 | 2008 | 2018 | Copa América (2011) |
{{sortname| Fernando | Muslera}} | 107 | 0 | 2009 | 2019 | Copa América (2011) |
{{sortname|Luis| Suárez}} | 106 | 55 | 2007 | 2018 | Copa América (2011) |
{{sortname|Diego|Lugano}} | 95 | 9 | 2003 | 2014 | Copa América (2011) |
{{sortname| Egidio | Arévalo Ríos}} | 90 | 0 | 2006 | 2017 | Copa América (2011) |
{{sortname| Diego | Pérez |Diego Pérez (footballer)}} | 89 | 2 | 2001 | 2014 | Copa América (2011) |
{{sortname|Martín|Cáceres|}} | 88 | 4 | 2007 | 2019 | Copa América (2011) |
{{sortname| Álvaro| Pereira}} | 83 | 7 | 2008 | 2016 | Copa América (2011) |
{{sortname|Rodolfo|Rodríguez|Rodolfo Rodríguez (Uruguayan footballer)}} | 78 | 0 | 1976 | 1986 | Copa América (1983) |
{{sortname|Fabián |Carini}} | 74 | 0 | 1999 | 2009 |
{{sortname|Enzo|Francescoli}} | 73 | 17 | 1982 | 1997 | Copa América (1983-1987-1995) |
{{sortname|Álvaro Rafael|González|}} | 70 | 3 | 2006 | 2017 | Copa América (2011) |
{{sortname|Sebastián|Abreu}} | 70 | 26 | 1996 | 2012 | Copa América (2011) |
{{sortname|Álvaro|Recoba|}} | 69 | 11 | 1995 | 2007 |
{{sortname|Ángel|Romano|}} | 69 | 28 | 1911 | 1927 | Olympic Games (1924), Copa América (1916-1917-1920-1924-1926) |
{{sortname|Pablo Gabriel|García|}} | 66 | 2 | 1997 | 2007 |
{{sortname|Carlos|Aguilera|}} | 64 | 22 | 1982 | 1997 | Copa América (1983) |
{{sortname|Walter|Gargano|}} | 64 | 1 | 2006 | 2014 | Copa América (2011) |
{{sortname|Paolo|Montero|}} | 61 | 5 | 1991 | 2005 |
{{sortname|Jorge|Barrios|Jorge Barrios (footballer)}} | 60 | 3 | 1980 | 1992 | Copa América (1983) |
{{sortname|Nelson|Gutiérrez|}} | 57 | 0 | 1983 | 1990 | Copa América (1987) |
{{sortname|José Oscar|Herrera|}} | 57 | 4 | 1988 | 1997 | Copa América (1995) |
{{sortname|Nicolás|Lodeiro|}} | 56 | 4 | 2009 | 2019 | Copa América (2011) |
{{sortname|Sebastián|Eguren|}} | 54 | 7 | 2001 | 2013 | Copa América (2011) |
{{sortname|William|Martínez|}} | 54 | 2 | 1950 | 1965 | World Cup (1950), Copa América (1956) |
{{sortname|Fernando|Morena|}} | 53 | 22 | 1971 | 1983 | Copa América (1983) |
{{sortname|Pedro|Rocha|}} | 52 | 17 | 1961 | 1974 | Copa América (1967) |
{{sortname|Héctor|Scarone|}} | 52 | 31 | 1917 | 1930 | Olympic games (1924-1928), World Cup (1930) |
{{sortname|Darío|Rodríguez|}} | 51 | 4 | 2000 | 2007 |
{{sortname|Néstor|Gonçalves|}} | 50 | 0 | 1957 | 1971 |
{{sortname|Cayetano|Saporiti|}} | 50 | 0 | 1905 | 1919 | Copa América (1916-1917) |
1. ^Uruguay – Record International Players