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词条 Luke A. J. O'Neill
释义

  1. Education

  2. Research

  3. Awards and honours

  4. Public engagement

  5. References

{{For|other people called Luke O'Neill|Luke O'Neill (disambiguation)}}{{EngvarB|date=August 2017}}{{Use dmy dates|date=August 2017}}{{Infobox scientist
| name = Luke O'Neill
| honorific_suffix = {{post-nominals|FRS|MRIA|size=100%}}
| field = Immunology[1]
| image = Professor Luke O'Neill FRS.jpg
| caption = Luke O'Neill at the Royal Society admissions day in London in 2016
|alma_mater={{Plainlist|
  • University of Dublin
  • University of London}}

|workplaces={{Plainlist|
  • Trinity College Dublin
  • Opsona Therapeutics}}

| thesis_title = Characterisation of interleukin-1-induced prostaglandin E₂ release in human synovial cells
| thesis_url =http://catalogue.ulrls.lon.ac.uk/record=b1534268~S24
| thesis_year = 1988
| awards = EMBO Member (2005)
| doctoral_advisor =
| doctoral_student =
| website = {{URL|people.tcd.ie/laoneill}}

}}Luke Anthony John O'Neill {{post-nominals|country=GBR|FRS}}[2] is professor of Biochemistry in the School of Biochemistry[2] and Immunology at Trinity College Dublin.[3][4][5][6]

Education

O'Neill was educated at Trinity College Dublin where he was awarded an undergraduate degree in Natural Sciences (Biochemistry) in 1985.[7] He completed his postgraduate study at the University of London where he was awarded a PhD in Pharmacology for the research investigating the characterisation of interleukin-1-induced prostaglandin E₂ release in human synovial cells in 1988.[8] Following his PhD, he was a postdoctoral researcher at the Strangeways Research Laboratory in Cambridge funded by the Medical Research Council (MRC).[7]

Research

O'Neill's research investigates inflammation, a highly complex process that is provoked in the body during infection by bacteria and viruses but also in response to major trauma and injury. Inflammation restores us to health but for largely unknown reasons it can go rogue and give rise to a whole range of inflammatory diseases which remain difficult to treat.[2][9]

He has worked on the innate immune system, which lies at the heart of inflammation. He has uncovered new molecules and biochemical processes that are triggered by sensors of infection and tissue injury, including the toll-like receptors[10][11][12][13] and inflammasomes, and the signals they drive that stimulate inflammation, notably cytokines in the interleukin-1 family. He has made pioneering discoveries in the area of metabolic reprogramming in immunity and immunometabolism. He is using his findings to help in the effort to develop novel anti-inflammatory medicines.[2] He has co-founded Inflazome with Matt Cooper and Sitryx with Houman Ashrafian, Johnathan Powell, Jeff Rathmell and Mike Rosenblum.

His research has been funded by the Science Foundation Ireland (SFI), the European Research Council (ERC), the Wellcome Trust and GlaxoSmithKline.[3]

Awards and honours

O'Neill was awarded the Royal Dublin Society & The Irish Times Robert Boyle Medal for scientific excellence in 2009,[14] the Royal Irish Academy Gold Medal for Life Sciences in 2012 and the European Federation of Immunology Societies (EFIS) Medal in 2014. He was elected a member of the Royal Irish Academy (MRIA) in 2004[15] and the European Molecular Biology Organisation (EMBO) in 2005.[16] O'Neill was elected a Fellow of the Royal Society (FRS) in 2016.[17]

He received The Milstein Award from the International Cytokine and Interferon Society and the Barcroft Medal from Queen's University Belfast in 2018.

Public engagement

O’Neill has a passion to engage with the general public on scientific topics. He has a weekly science slot with Pat Kenny on the Irish national radio station Newstalk. In 2018 he published Humanology: A Scientist’s Guide to our Amazing Existence with Gill publishers.[18]

References

1. ^{{cite journal |last1=Brint|first1=Elizabeth K|last2=Xu|first2=Damo|last3=Liu|first3=Haiying|last4=Dunne|first4=Aisling|last5=McKenzie|first5=Andrew N J|authorlink5=Andrew N. J. McKenzie|last6=O'Neill|first6=Luke A J|authorlink6=Luke A. J. O'Neill|last7=Liew|first7=Foo Y | title = ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance | journal = Nature Immunology | volume = 5 | issue = 4 | pages = 373–9 |year=2004 | pmid = 15004556 | doi = 10.1038/ni1050 }}
2. ^{{Scopus id}}
3. ^1 {{cite web|archiveurl=https://web.archive.org/web/20150915164931/http://people.tcd.ie/Profile?Username=laoneill|archivedate=2015-09-15|url=http://people.tcd.ie/Profile?Username=laoneill|title=Professor Luke O'Neill: Chair of Biochemistry (1960)|publisher=tcd.ie|location=Dublin}}
4. ^{{YouTube|id=iTJ5OK-1FCs|title=Interview with Professor Luke O'Neill of Trinity College Dublin}}
5. ^{{YouTube|id=ej3KLitdKtw|title=In Conversation: Professor Luke O'Neill}}
6. ^{{cite web|archiveurl=https://web.archive.org/web/20160523203315/http://expert.knowledgetransferireland.com/experts/108203|archivedate=2016-05-23|url=http://expert.knowledgetransferireland.com/experts/108203|title=Luke Anthony John O'Neill|publisher=knowledgetransferireland.com}}
7. ^1 {{cite journal|url=http://www.jbc.org/content/suppl/2009/03/19/284.13.8209.DC1/284.13.8209_ONeillLuke.pdf|journal=Journal of Biological Chemistry |title=Luke A. J. O'Neill|archiveurl=https://web.archive.org/web/20160523223355/http://www.jbc.org/content/suppl/2009/03/19/284.13.8209.DC1/284.13.8209_ONeillLuke.pdf|archivedate=2016-05-23|doi=10.1074/jbc.R800070200|volume=284|page=8209|pmc=2659175}}
8. ^{{cite thesis |degree=PhD |first=Luke Anthony John|last=O'Neill |title=Characterisation of interleukin-1-induced prostaglandin E₂ release in human synovial cells|year=1988 |url=http://catalogue.ulrls.lon.ac.uk/record=b1534268~S248 |oclc=940166978|publisher=University of London}}
9. ^{{cite journal|last1=O'Neill|first1=L.A.J|last2=Kaltschmidt|first2=C.|title=NF-kB: a crucial transcription factor for glial and neuronal cell function|journal=Trends in Neurosciences|volume=20|issue=6|year=1997|pages=252–258|doi=10.1016/S0166-2236(96)01035-1|pmid=9185306}}
10. ^{{cite journal|last1=Fitzgerald|first1=Katherine A.|last2=Palsson-McDermott|first2=Eva M.|last3=Bowie|first3=Andrew G.|last4=Jefferies|first4=Caroline A.|last5=Mansell|first5=Ashley S.|last6=Brady|first6=Gareth|last7=Brint|first7=Elizabeth|last8=Dunne|first8=Aisling|last9=Gray|first9=Pearl|last10=Harte|first10=Mary T.|last11=McMurray|first11=Diane|last12=Smith|first12=Dirk E.|last13=Sims|first13=John E.|last14=Bird|first14=Timothy A.|last15=O'Neill|first15=Luke A. J.|title=Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction|journal=Nature|volume=413|issue=6851|year=2001|pages=78–83|doi=10.1038/35092578|pmid=11544529}}
11. ^{{cite journal|last1=Palsson-McDermott|first1=Eva M.|last2=O'Neill|first2=Luke A. J.|title=Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4|journal=Immunology|volume=113|issue=2|year=2004|pages=153–162|pmid=15379975|doi=10.1111/j.1365-2567.2004.01976.x|pmc=1782563}} {{open access}}
12. ^{{cite journal|last1=O'Neill|first1=Luke A. J.|last2=Bowie|first2=Andrew G.|title=The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling|journal=Nature Reviews Immunology|volume=7|issue=5|year=2007|pages=353–364|doi=10.1038/nri2079|pmid=17457343}}
13. ^{{cite journal|last1=Liew|first1=Foo Y.|last2=Xu|first2=Damo|last3=Brint|first3=Elizabeth K.|last4=O'Neill|first4=Luke A. J.|title=Negative regulation of Toll-like receptor-mediated immune responses|journal=Nature Reviews Immunology|volume=5|issue=6|year=2005|pages=446–458|doi=10.1038/nri1630|pmid=15928677}}
14. ^[https://www.rds.ie/Ireland-s-Philanthropic-Society/Our-Work/Projects/RDS-Irish-Times-Boyle-Medal-for-Scientific-Excelle/Boyle-Medal-Laureates Boyle Medal Laureates] Royal Dublin Society
15. ^{{cite news |first=John |last=Downes |title=20 new members elected to Royal Irish Academy |url=https://www.irishtimes.com/news/20-new-members-elected-to-royal-irish-academy-1.1135749 |work=The Irish Times |date=17 March 2004 |accessdate=26 December 2018}}
16. ^{{cite web|author=Anon|year=2005|url=http://people.embo.org/profile/luke-oneill|publisher=embo.org|location=Heidelberg|title=EMBO Member Luke O'Neill: Trinity College, Dublin, EMBO 2005}}
17. ^1 2 3 {{cite web|url=https://royalsociety.org/people/lukeoneill12887/ |title=Professor Luke O'Neill FRS |publisher=Royal Society |archivedate=2016-04-29 |archiveurl=https://web.archive.org/web/20160429121651/https://royalsociety.org/people/lukeoneill12887/ |location=London |author=Anon |year=2016 }} One or more of the preceding sentences incorporates text from the royalsociety.org website where: {{quote|"All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License." --{{cite web|url=https://royalsociety.org/about-us/terms-conditions-policies/ |title=Royal Society Terms, conditions and policies |accessdate=2016-03-09 |deadurl=bot: unknown |archiveurl=https://web.archive.org/web/20150925220834/https://royalsociety.org/about-us/terms-conditions-policies/ |archivedate=2015-09-25 |df= }}}}
18. ^{{cite book |first=Luke |last=O'Neill |title=Humanology: A Scientist’s Guide to our Amazing Existence |publisher=Gill Books |date=2018 |isbn=978-0-7171-8015-8}}
{{FRS 2016}}{{Authority control}}{{DEFAULTSORT:ONeill, Luke}}

4 : Members of the European Molecular Biology Organization|Living people|Fellows of the Royal Society|Year of birth missing (living people)
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