| 词条 | LysM domain |
| 释义 |
| Symbol = LysM | Name = LysM domain | image = PDB 1e0g EBI.jpg | width = 250 | caption = | Pfam = PF01476 | InterPro = IPR000644 | SMART = LysM | PROSITE = PS51782 | SCOP = 1e0g | TCDB = | CDD = cd00118 | OPM family = | OPM protein = | PDB = | Membranome family = 1306 }} In molecular biology the LysM domain is a protein domain found in a wide variety of extracellular proteins and receptors. The LysM domain is named after the Lysin Motif which was the original name given to the sequence motif identified in bacterial proteins. The region was originally identified as a C-terminal repeat found in the Enterococcus hirae muramidase.[1] The LysM domain is found in a wide range of microbial extracellular proteins, where the LysM domain is thought to provide an anchoring to extracellular polysaccharides such as peptidoglycan and chitin. LysM domains are found in plant receptor kinases for the Nod factor where they bind to symbiotic bacteria in the root nodule. The LysM domain is typically between 44 and 65 amino acid residues in length.[2] The structure of the LysM domain showed that it is composed of a pair of antiparallel beta strands separated by a pair of short alpha helices.[3] See alsoNod factorReferences1. ^{{cite journal | vauthors = Joris B, Englebert S, Chu CP, Kariyama R, Daneo-Moore L, Shockman GD, Ghuysen JM | title = Modular design of the Enterococcus hirae muramidase-2 and Streptococcus faecalis autolysin | journal = FEMS Microbiology Letters | volume = 70 | issue = 3 | pages = 257–64 | date = March 1992 | pmid = 1352512 }} 2. ^{{cite journal | vauthors = Buist G, Steen A, Kok J, Kuipers OP | title = LysM, a widely distributed protein motif for binding to (peptido)glycans | journal = Molecular Microbiology | volume = 68 | issue = 4 | pages = 838–47 | date = May 2008 | pmid = 18430080 | doi = 10.1111/j.1365-2958.2008.06211.x }} 3. ^{{cite journal | vauthors = Bateman A, Bycroft M | title = The structure of a LysM domain from E. coli membrane-bound lytic murein transglycosylase D (MltD) | journal = Journal of Molecular Biology | volume = 299 | issue = 4 | pages = 1113–9 | date = June 2000 | pmid = 10843862 | doi = 10.1006/jmbi.2000.3778 }} 1 : Protein domains |
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