| 释义 |
- Function
- References
- Further reading
{{Infobox_gene}}Mannose receptor C-type 1 is a protein that in humans is encoded by the MRC1 gene. [1]FunctionThe recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. References 1. ^{{cite web| title = Entrez Gene: Mannose receptor C-type 1| url = https://www.ncbi.nlm.nih.gov/gene/4360| accessdate = 2018-10-15}}
Further reading {{refbegin | 2}}- {{cite journal |vauthors=DesJardin LE, Kaufman TM, Potts B, Kutzbach B, Yi H, Schlesinger LS |title=Mycobacterium tuberculosis-infected human macrophages exhibit enhanced cellular adhesion with increased expression of LFA-1 and ICAM-1 and reduced expression and/or function of complement receptors, FcgammaRII and the mannose receptor |journal=Microbiology |volume=148 |issue=Pt 10 |pages=3161–71 |date=October 2002 |pmid=12368450 |doi=10.1099/00221287-148-10-3161 |url=}}
- {{cite journal |vauthors=Chieppa M, Bianchi G, Doni A, Del Prete A, Sironi M, Laskarin G, Monti P, Piemonti L, Biondi A, Mantovani A, Introna M, Allavena P |title=Cross-linking of the mannose receptor on monocyte-derived dendritic cells activates an anti-inflammatory immunosuppressive program |journal=J. Immunol. |volume=171 |issue=9 |pages=4552–60 |date=November 2003 |pmid=14568928 |doi= |url=}}
- {{cite journal |vauthors=Chan TL, Chan YW, Ho JW, Chan C, Chan AS, Chan E, Lam PW, Tse CW, Lee KC, Lau CW, Gwi E, Leung SY, Yuen ST |title=MSH2 c.1452-1455delAATG is a founder mutation and an important cause of hereditary nonpolyposis colorectal cancer in the southern Chinese population |journal=Am. J. Hum. Genet. |volume=74 |issue=5 |pages=1035–42 |date=May 2004 |pmid=15042510 |pmc=1181966 |doi=10.1086/383591 |url=}}
- {{cite journal |vauthors=Zhang J, Zhu J, Imrich A, Cushion M, Kinane TB, Koziel H |title=Pneumocystis activates human alveolar macrophage NF-kappaB signaling through mannose receptors |journal=Infect. Immun. |volume=72 |issue=6 |pages=3147–60 |date=June 2004 |pmid=15155616 |pmc=415687 |doi=10.1128/IAI.72.6.3147-3160.2004 |url=}}
- {{cite journal |vauthors=Napper CE, Taylor ME |title=The mannose receptor fails to enhance processing and presentation of a glycoprotein antigen in transfected fibroblasts |journal=Glycobiology |volume=14 |issue=10 |pages=7C–12C |date=October 2004 |pmid=15190005 |doi=10.1093/glycob/cwh109 |url=}}
- {{cite journal |vauthors=Le Cabec V, Emorine LJ, Toesca I, Cougoule C, Maridonneau-Parini I |title=The human macrophage mannose receptor is not a professional phagocytic receptor |journal=J. Leukoc. Biol. |volume=77 |issue=6 |pages=934–43 |date=June 2005 |pmid=15767290 |doi=10.1189/jlb.1204705 |url=}}
- {{cite journal |vauthors=Zhang J, Tachado SD, Patel N, Zhu J, Imrich A, Manfruelli P, Cushion M, Kinane TB, Koziel H |title=Negative regulatory role of mannose receptors on human alveolar macrophage proinflammatory cytokine release in vitro |journal=J. Leukoc. Biol. |volume=78 |issue=3 |pages=665–74 |date=September 2005 |pmid=16000387 |doi=10.1189/jlb.1204699 |url=}}
- {{cite journal |vauthors=Kang PB, Azad AK, Torrelles JB, Kaufman TM, Beharka A, Tibesar E, DesJardin LE, Schlesinger LS |title=The human macrophage mannose receptor directs Mycobacterium tuberculosis lipoarabinomannan-mediated phagosome biogenesis |journal=J. Exp. Med. |volume=202 |issue=7 |pages=987–99 |date=October 2005 |pmid=16203868 |pmc=2213176 |doi=10.1084/jem.20051239 |url=}}
- {{cite journal |vauthors=Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A |title=A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease |journal=Am. J. Hum. Genet. |volume=78 |issue=1 |pages=78–88 |date=January 2006 |pmid=16385451 |pmc=1380225 |doi=10.1086/498851 |url=}}
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