| 词条 | Margin of exposure |
| 释义 |
In toxicology, the margin of exposure (or MOE) of a substance is the ratio of its no-observed-adverse-effect level to its theoretical, predicted, or estimated dose or concentration of human intake.[1] It is used in risk assessment to determine the dangerousness of substances that are both genotoxic and carcinogenic.[2] This approach is preferred by both the World Health Organization and the European Food Safety Authority for the evaluation of the risk of carcinogens.[3] References1. ^{{cite journal|last1=Benford|first1=Diane|last2=Bolger|first2=P. Michael|last3=Carthew|first3=Philip|last4=Coulet|first4=Myriam|last5=DiNovi|first5=Michael|last6=Leblanc|first6=Jean-Charles|last7=Renwick|first7=Andrew G.|last8=Setzer|first8=Woodrow|last9=Schlatter|first9=Josef|last10=Smith|first10=Benjamin|last11=Slob|first11=Wout|last12=Williams|first12=Gary|last13=Wildemann|first13=Tanja|title=Application of the Margin of Exposure (MOE) approach to substances in food that are genotoxic and carcinogenic|journal=Food and Chemical Toxicology|date=January 2010|volume=48|pages=S2–S24|doi=10.1016/j.fct.2009.11.003}} {{Toxicology-stub}}2. ^{{cite web | url=http://www.efsa.europa.eu/en/topics/topic/margin-exposure | title=Margin of Exposure approach developed by EFSA | work=EFSA | accessdate=20 November 2015}} 3. ^{{cite journal|last1=Lachenmeier|first1=Dirk W.|last2=Przybylski|first2=Maria C.|last3=Rehm|first3=Jürgen|title=Comparative risk assessment of carcinogens in alcoholic beverages using the margin of exposure approach|journal=International Journal of Cancer|date=15 September 2012|volume=131|issue=6|pages=E995–E1003|doi=10.1002/ijc.27553|pmid=22447328|citeseerx=10.1.1.690.3319}} 1 : Toxicology |
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