| 词条 | Marrow adipose tissue | ||||
| 释义 |
| Name = Marrow adipose tissue | Latin = | Greek = | Image = Marrow Adipocytes are derived from mesenchymal stem cell (MSC) differentiation.png | Caption = Illustration of MSC differentiation into adipocytes and osteoblasts | Width = | Image2 = | Caption2 = | Precursor = | System = | Artery = | Vein = | Nerve = | Lymph = }} Marrow adipose tissue (MAT) , also known as bone marrow adipose tissue (BMAT), increases in states of low bone density -osteoporosis,[1][2] anorexia nervosa/ caloric restriction,[3] skeletal unweighting,[4][5] anti-diabetes therapies[6]). The marrow adipocytes originate from mesenchymal stem cell (MSC) progenitors that also give rise to osteoblasts, among other cell types.[7] Thus, it is thought that MAT results from preferential MSC differentiation into the adipocyte, rather than osteoblast, lineage in the setting of osteoporosis.[8] Since MAT is increased in the setting of obesity[9][10][11] and is suppressed by endurance exercise,[12][9][13][14]or vibration,[15] it is likely that MAT physiology- in the setting of mechanical input/exercise- approximates that of white adipose tissue (WAT). The first study to demonstrate exercise regulation of MAT in rodents was published in 2014;[9] now, exercise regulation of MAT has been confirmed in a human study as well[16] adding clinical significance to this work. MAT has qualities of both white and brown fat.[17] Subcutaneous white fat contain excess energy, indicating a clear evolutionary advantage during times of scarcity. WAT is also the source of adipokines and inflammatory markers which have both positive (e.g., adiponectin)[18] and negative[19] effects on metabolic and cardiovascular endpoints. Visceral abdominal fat (VAT) is a distinct type of WAT that is "proportionally associated with negative metabolic and cardiovascular morbidity",[20] regenerates cortisol,[21] and recently has been tied to decreased bone formation[22][23] Both types of WAT substantially differ from brown adipose tissue (BAT) as by a group of proteins that help BAT’s thermogenic role.[24] MAT, by its "specific marrow location, and its adipocyte origin from at least LepR+ marrow MSC is separated from non-bone fat storage by larger expression of bone transcription factors",[25] and likely indicates a different fat phenotype.[26] Recently, MAT was noted to "produce a greater proportion of adiponectin - an adipokine associated with improved metabolism - than WAT",[27] suggesting an endocrine function for this depot, akin, but different, from that of WAT. Marrow Adipose Tissue (MAT) and Bone HealthMAT increases in states of bone fragility. MAT is thought to result from preferential MSC differentiation into an adipocyte, rather than osteoblast lineage in osteoporosis[28] based on the inverse relationship between bone and MAT in bone-fragile osteoporotic states. An increase in MAT is noted in osteoporosis clinical studies measured by MR Spectroscopy.[29][30][31] Estrogen therapy in postmenopausal osteoporosis reduces MAT.[32] Antiresorptive therapies like risedronate or zoledronate also decrease MAT while increasing bone density, supporting an inverse relationship between bone quantity and MAT. During aging, bone quantity declines[33][34] and fat redistributes from subcutaneous to ectopic sites such as bone marrow, muscle, and liver.[35] Aging is associated with lower osteogenic and greater adipogenic biasing of MSC.[36] This aging-related biasing of MSC away from osteoblast lineage may represent higher basal PPARγ expression[37] or decreased Wnt10b.[38][39][40] Thus, bone fragility, osteoporosis, and osteoporotic fractures are thought to be linked to mechanisms which promote MAT accumulation. Measurement of Marrow Adipose TissueIn order to understand the physiology of MAT, various analytic methods have been applied. Marrow adipocytes are difficult to isolate and quantify because they are interspersed with bony and hematopoietic elements. Until recently, qualitative measurements of MAT have relied on bone histology,[41][42] which is subject to site selection bias and cannot adequately quantify the volume of fat in the marrow. Nevertheless, histological techniques and fixation make possible visualization of MAT, quantification of adipocyte size, and MAT’s association with the surrounding endosteum, milieu of cells, and secreted factors.[43][44][45] Recent advances in cell surface and intracellular marker identification and single-cell analyses led to greater resolution and high-throughput ex-vivo quantification. Flow cytometric quantification can be used to purify adipocytes from the stromal vascular fraction of most fat depots.[46] Early research with such machinery cited adipocytes as too large and fragile for cytometer-based purification, rendering them susceptible to lysis; however, recent advances have been made to mitigate this;[47] nevertheless, this methodology continues to pose technical challenges[48] and is inaccessible to much of the research community. To improve quantification of MAT, novel imaging techniques have been developed as a means to visualize and quantify MAT. Although proton magnetic resonance spectroscopy (1H-MRS) has been used with success to quantify vertebral MAT in humans,[49] it is difficult to employ in laboratory animals.[50] Magnetic resonance imaging (MRI) provides MAT assessment in the vertebral skeleton[51] in conjunction with μCT-based marrow density measurements.[52] A volumetric method to identify, quantify, and localize MAT in rodent bone has been recently developed, requiring osmium staining of bones and μCT imaging,[53] followed by advanced image analysis of osmium-bound lipid volume (in mm3) relative to bone volume.[9][13][12] This technique provides reproducible quantification and visualization of MAT, enabling the ability to consistently quantify changes in MAT with diet, exercise, and agents that constrain precursor lineage allocation. Although the osmium method is quantitatively precise, osmium is toxic and cannot be compared across batched experiments. Recently, researchers developed and validated[13] a 9.4T MRI scanner technique that allows localization and volumetric (3D) quantification that can be compared across experiments. Marrow Adipose Tissue and Hematopoietic CellsHematopoietic cells (also known as blood cells) reside in the bone marrow along with marrow adipocytes. These hematopoietic cells are derived from hematopoietic stem cells (HSC) which give rise to diverse cells: cells of the blood, immune system, as well as cells that break down bone (osteoclasts). HSC renewal occurs in the marrow stem cell nichReferences{{CC-notice|cc=by4|url=http://journal.frontiersin.org/article/10.3389/fendo.2016.00094/full|author(s)=Gabriel M. 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2 : Bone marrow|Bone fractures |
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