| 词条 | Mary Fenner Dallman |
| 释义 |
LifeMary Dallman has three children with her husband Peter Dallman, a professor of pediatric medicine at UCSF. CareerDallman received her bachelor's degree in Chemistry[3] from Smith College (1956) and completed her Ph.D. in Physiology at Stanford University in the laboratory of F. Eugene Yates (1967). Dallman then pursued two post-doctoral training stints, the first in Neuroscience in Stockholm, Sweden with Bengt Andersson and the second at UCSF in Neuroendocrinology with William Francis Ganong. She stayed on at UCSF thereafter, hired first as a lecturer for two years, before establishing her own lab as an assistant professor (1972), rising to full professor and serving as vice chair of the department for fourteen years. She is now professor emerita at University of California, San Francisco,[1] where she was the first tenure-track female faculty member in the Department of Physiology and worked for 38 years before retiring in 2007. She is known for her elucidation of function along the hypothalamic, pituitary, adrenal axis, and the discovery that comfort foods dampen the stress response.[2] Her lab explored the role of glucocorticoid feedback on the HPA axis [4][5], showing that there is a very fast (seconds-minutes) inhibitory effect [6], and that sufficiently intense stimuli to the stress-response system use central networks that appear to bypass central glucocorticoid inhibition of subsequent system activity [7]. The lab also provided evidence that efferent adrenal nerves regulate both compensatory adrenal growth after unilateral adrenalectomy [8], and the diurnal rhythm in adrenocortical sensitivity to ACTH secretion [9]. The finding that body weight, fat content, and activity in the HPA axis are tightly correlated [10] initiated subsequent studies that ultimately showed that only voluntary intake of lard inhibits adrenocortical responses to subsequent stressors [11]. Dallman has been recognized for her contributions in many ways:
References1. ^1 {{Cite web|url=http://nextmission.ucsf.edu/our-team|title=Our Team {{!}} Next Mission|website=nextmission.ucsf.edu|access-date=2018-01-14}} {{DEFAULTSORT:Dallman, Mary}}2. ^1 {{Cite web|url=https://www.ucsf.edu/news/2011/12/11089/comfort-food-may-be-self-medication-stress-dialing-down-stress-response|title=Comfort Food May Be "Self-Medication" for Stress, Dialing Down Stress Response|website=UC San Francisco|language=en|access-date=2018-01-14}} 3. ^{{Cite web|url=https://www.ucsf.edu/news/2007/07/3716/dallman|title=The Biology of Fat (or Why Literally Running Away from Stress Is a Good Idea)|website=UC San Francisco|language=en|access-date=2018-01-14}} 4. ^{{Cite journal|title=Regulation of ACTH secretion: variations on a theme of B. Recent Prog Horm Res}} 5. ^{{Cite journal|title=Dallman MF, Akana SF, Bhatnagar S., Bell ME, Strack AM: Bottomed out: metabolic significance of the circadian trough in glucocorticoid concentrations, Int J Obesity, 24, 2000, Suppl.2, S40-S46}} 6. ^{{Cite journal|title=Corticosterone-induced changes in hypothalamic corticotropin-releasing factor (CRF) content after stress}} 7. ^{{Cite journal|title=Interaction between stimulus intensity and corticosteroid feedback in control of ACTH}} 8. ^{{Cite journal|title=Compensatory adrenal growth: a neurally mediated reflex}} 9. ^{{Cite journal|title=Nycthemeral rhythm in adrenal responsiveness to ACTH}} 10. ^{{Cite journal|title=Corticosterone: narrow range required for normal body and thymus weight and ACTH}} 11. ^{{Cite journal|title=Choice of lard, but not total lard calories, damps ACTH responses to restraint}} 12. ^{{cite journal|last1=Wood|first1=Charles|title=When lab leaders take too much control|journal=Nature|date=28 Nov 2012|volume=491|page=785|doi=10.1038/nj7426-785a}} 6 : Women neuroscientists|Living people|Smith College alumni|Stanford University alumni|1935 births|University of California, San Francisco faculty |
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