“Acetate CoA-transferase”的意思、由来-开放百科全书

词条

Acetate CoA-transferase

释义

Structural studies
References
External links

{{enzyme
| Name = acetate CoA-transferase
| EC_number = 2.8.3.8
| CAS_number = 37278-35-6
| IUBMB_EC_number = 2/8/3/8
| GO_code = 0008775
| image =
| width =
| caption =
}}

In enzymology, an acetate CoA-transferase ({{EC number|2.8.3.8}}) is an enzyme that catalyzes the chemical reaction

acyl-CoA + acetate a fatty acid anion + acetyl-CoA

Thus, the two substrates of this enzyme are acyl-CoA and acetate, whereas its two products are fatty acid anion and acetyl-CoA.

This enzyme belongs to the family of transferases, specifically the CoA-transferases. The systematic name of this enzyme class is acyl-CoA:acetate CoA-transferase. Other names in common use include acetate coenzyme A-transferase, butyryl CoA:acetate CoA transferase, butyryl coenzyme A transferase, and succinyl-CoA:acetate CoA transferase. This enzyme participates in 4 metabolic pathways: benzoate degradation via coa ligation, propanoate metabolism, butanoate metabolism, and two-component system - general.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code {{PDB link|1K6D}}.

References

{{cite journal |vauthors=Vanderwinkel E, Furmanski P, Reeves HC, Ajl SJ | date = 1968 | title = Growth of Escherichia coli on fatty acids: requirement for coenzyme A transferase activity | journal = Biochem. Biophys. Res. Commun. | volume = 33 | pages = 902–8 | pmid = 4884054 | doi = 10.1016/0006-291X(68)90397-5 | issue = 6 }}
{{cite journal |vauthors=Kaschabek SR, Kuhn B, Muller D, Schmidt E, Reineke W | date = 2002 | title = Degradation of aromatics and chloroaromatics by Pseudomonas sp strain B13: purification and characterization of 3-oxoadipate:succinyl-coenzyme A (CoA) transferase and 3-oxoadipyl-CoA thiolase | journal = J. Bacteriol. | volume = 184 | pages = 207–15 | pmid = 11741862 | doi = 10.1128/JB.184.1.207-215.2002 | issue = 1 | pmc = 134768 }}
{{cite journal |vauthors=Gobel M, Kassel-Cati K, Schmidt E, Reineke W | date = 2002 | title = Degradation of aromatics and chloroaromatics by Pseudomonas sp strain B13: cloning, characterization, and analysis of sequences encoding 3-oxoadipate:succinyl-coenzyme A (CoA) transferase and 3-oxoadipyl-CoA thiolase | journal = J. Bacteriol. | volume = 184 | pages = 216–23 | pmid = 11741863 | doi = 10.1128/JB.184.1.216-223.2002 | issue = 1 | pmc = 134769 }}

External links

{{Commonscatinline}}

{{Sulfur-containing group transferases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{2.8-enzyme-stub}}

2 : EC 2.8.3|Enzymes of known structure

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