| 词条 | MDPHP |
| 释义 |
| drug_name = 3',4'-Methylenedioxy-α-pyrrolidinohexiophenone | IUPAC_name = 1-(2H-1,3-Benzodioxol-5-yl)-2-(pyrrolidin-1-yl)hexan-1-one | image = MDPHP.svg | CAS_number = 776994-64-0 | ATC_prefix = | ATC_suffix = | PubChem = 119057580 | UNII = 7P3X2C24CS | DrugBank = | ChemSpiderID = 52085733 | C=17|H=23|N=1|O=3 | molecular_weight = 289.369 g/mol | smiles = CCCCC(N1CCCC1)C(=O)c2ccc3OCOc3c2 | StdInChI = 1S/C17H23NO3/c1-2-3-6-14(18-9-4-5-10-18)17(19)13-7-8-15-16(11-13)21-12-20-15/h7-8,11,14H,2-6,9-10,12H2,1H3 | StdInChIKey = OBLFRFGUZZRECT-UHFFFAOYSA-N | SMILES = CCCCC(C(=O)C1=CC2=C(C=C1)OCO2)N3CCCC3 | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | pregnancy_AU = | pregnancy_US = | pregnancy_category= | legal_AU = | legal_CA = | legal_UK = Class B | legal_US = | legal_status = Illegal in Japan and Hungary | routes_of_administration = | UNII_Ref = {{fdacite|correct|FDA}} }}MDPHP (3',4'-Methylenedioxy-α-pyrrolidinohexiophenone) is a stimulant of the cathinone class originally developed in the 1960s,[1] which has been reported as a novel designer drug. In the UK its slang name is monkey dust.[2] It is closely related to the potent stimulant MDPV though with slightly milder effects, and has been used as an alternative in some countries following the banning of MDPV.[3][4][5][6] Legal StatusMDPHP is specifically listed as a controlled substance in Japan [7] and Hungary,[8] and is controlled under analogue provisions in a number of other jurisdictions. See also
References1. ^{{citation|first1=Koeppe|last1=Herbert|first2=Zeile|last2=Karl|first3=Ludwig|last3=Gerhard|title=Patent DE1545591 - Verfahren zur Herstellung von α-Aminoketonen mit heterocyclischer Aminogruppe|url=https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19690807&DB=&locale=en_EP&CC=DE&NR=1545591A1&KC=A1|date=28 May 1965|language=de}} {{Stimulants}}{{Adrenergics}}{{Dopaminergics}}{{MDxx}}{{nervous-system-drug-stub}}2. ^{{cite web |url= https://www.bbc.com/news/uk-england-stoke-staffordshire-45144531 |title= Monkey Dust drug use 'an epidemic', emergency workers warn |work= BBC |date= 10 August 2018 |access-date= 16 August 2018}} 3. ^Zaitsu K, Katagi M, Tsuchihashi H, Ishii A. Recently abused synthetic cathinones, α-pyrrolidinophenone derivatives: a review of their pharmacology, acute toxicity, and metabolism. Forensic Toxicology 2014 Jan; 32(1):1-8. {{Cite journal|doi=10.1007/s11419-013-0218-1|title=Recently abused synthetic cathinones, α-pyrrolidinophenone derivatives: A review of their pharmacology, acute toxicity, and metabolism|journal=Forensic Toxicology|volume=32|pages=1|year=2013|last1=Zaitsu|first1=Kei|last2=Katagi|first2=Munehiro|last3=Tsuchihashi|first3=Hitoshi|last4=Ishii|first4=Akira}} 4. ^Kaizaki-Mitsumoto A, et al. Three 25-NBOMe-type drugs, three other phenethylamine-type drugs (25I-NBMD, RH34, and escaline), eight cathinone derivatives, and a phencyclidine analog MMXE, newly identified in ingredients of drug products before they were sold on the drug market. Forensic Toxicology 2016 Jan; 34(1):108-114. {{Cite journal|doi=10.1007/s11419-015-0293-6|title=Three 25-NBOMe-type drugs, three other phenethylamine-type drugs (25I-NBMD, RH34, and escaline), eight cathinone derivatives, and a phencyclidine analog MMXE, newly identified in ingredients of drug products before they were sold on the drug market|journal=Forensic Toxicology|volume=34|pages=108|year=2015|last1=Kaizaki-Mitsumoto|first1=Asuka|last2=Noguchi|first2=Naoki|last3=Yamaguchi|first3=Saki|last4=Odanaka|first4=Yuki|last5=Matsubayashi|first5=Satoko|last6=Kumamoto|first6=Hiroki|last7=Fukuhara|first7=Kiyoshi|last8=Funada|first8=Masahiko|last9=Wada|first9=Kiyoshi|last10=Numazawa|first10=Satoshi}} 5. ^Beck O, Bäckberg M, Signell P, Helander A. Intoxications in the STRIDA project involving a panorama of psychostimulant pyrovalerone derivatives, MDPV copycats. Clin Toxicol (Phila). 2017 Sep 12:1-8. {{Cite journal|doi=10.1080/15563650.2017.1370097|pmid=28895757|year=2017|author1=Beck|first1=O|title=Intoxications in the STRIDA project involving a panorama of psychostimulant pyrovalerone derivatives, MDPV copycats|journal=Clinical toxicology (Philadelphia, Pa.)|pages=1–8|last2=Bäckberg|first2=M|last3=Signell|first3=P|last4=Helander|first4=A}} 6. ^Fowble KL, Shepard JRE, Musah RA. Identification and classification of cathinone unknowns by statistical analysis processing of direct analysis in real time-high resolution mass spectrometry-derived "neutral loss" spectra. Talanta. 2018 Mar 1;179:546-553. {{Cite journal|doi=10.1016/j.talanta.2017.11.020|pmid=29310273|year=2018|author1=Fowble|first1=K. L|title=Identification and classification of cathinone unknowns by statistical analysis processing of direct analysis in real time-high resolution mass spectrometry-derived "neutral loss" spectra|journal=Talanta|volume=179|pages=546–553|last2=Shepard|first2=J. R. E|last3=Musah|first3=R. A}} 7. ^{{cite web | url=http://www.mhlw.go.jp/seisakunitsuite/bunya/kenkou_iryou/iyakuhin/yakubuturanyou/dl/meisho.pdf | title=指定薬物名称・構造式一覧（平成27年9月16日現在） | publisher=厚生労働省 | date=16 September 2015 | language=Japanese | accessdate=8 October 2015}} 8. ^ 3 : Designer drugs|Pyrrolidinophenones|Benzodioxoles |
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