| 词条 | Aconitum carmichaelii | ||
| 释义 |
|image = Aconitum carmichaelli 'arendsii' 27-10-2005 16.09.36.JPG |genus = Aconitum |species = carmichaelii |authority = Debeaux }} Aconitum carmichaelii syn. A. fischeri, is a species of flowering plant of the genus Aconitum, family Ranunculaceae. It is native to East Asia and eastern Russia. It is commonly known as Chinese aconite, Carmichael's monkshood or Chinese wolfsbane ({{zh|t=烏頭附子|p=Wu-tou Fu-zi}}) ({{lang-ja|鳥兜 or トリカブト, Torikabuto}}). It is known in Mandarin as Fu Zi (meaning daughter root, or lateral root) and as Wu Tou (meaning tuberous mother root, or root tuber). DescriptionGrowing to {{convert|1.2|m|ft|0}} tall by {{convert|30|cm|0}} wide,[1] it is an erect perennial, with 3- to 5-lobed ovate, leathery leaves. Dense panicles of blue flowers are produced in late summer and autumn. It is valued as a garden plant, and numerous cultivars have been developed, of which 'Arendsii'[1] and 'Kelmscott'[2] (Wilsonii Group) have gained the Royal Horticultural Society's Award of Garden Merit.[3] Biological effectsAll parts of this plant are extremely toxic,[4] and it has historically been used as a poison on arrows.[5] If not prepared properly by a trained person, Aconitum can be deadly when taken internally. ToxicologyMarked symptoms may appear almost immediately, usually not later than one hour, and "with large doses death is almost instantaneous." Death usually occurs within two to six hours in fatal poisoning (20 to 40 mL of tincture may prove fatal).[6] The initial signs are gastrointestinal including nausea, vomiting, and diarrhea. This is followed by a sensation of burning, tingling, and numbness in the mouth and face, and of burning in the abdomen.[7] In severe poisonings pronounced motor weakness occurs and cutaneous sensations of tingling and numbness spread to the limbs. Cardiovascular features include hypotension, sinus bradycardia, and ventricular arrhythmias. Other features may include sweating, dizziness, difficulty in breathing, headache, and confusion. The main causes of death are ventricular arrhythmias and asystole, paralysis of the heart or of the respiratory center.[6][8] The only post-mortem signs are those of asphyxia.[7] Treatment of poisoning is mainly supportive. All patients require close monitoring of blood pressure and cardiac rhythm. Gastrointestinal decontamination with activated charcoal can be used if given within one hour of ingestion.[9] The major physiological antidote is atropine, which is used to treat bradycardia. Other drugs used for ventricular arrhythmia include lidocaine, amiodarone, bretylium, flecainide, procainamide, and mexiletine. Cardiopulmonary bypass is used if symptoms are refractory to treatment with these drugs.[8] Successful use of charcoal hemoperfusion has been claimed in patients with severe aconite poisoning.[10] Poisoning may also occur following picking the leaves without wearing gloves; the aconitine toxin is absorbed easily through the skin. In this event, there will be no gastrointestinal effects. Tingling will start at the point of absorption and extend up the arm to the shoulder, after which the heart will start to be affected. The tingling will be followed by unpleasant numbness. Treatment is similar to poisoning caused by oral ingestion.{{citation needed|date=July 2012}} Aconitine is a potent neurotoxin that opens tetrodotoxin-sensitive sodium channels. It increases influx of sodium through these channels and delays repolarization, thus increasing excitability and promoting ventricular dysrhythmias. Chemical constituents
The {{LD50}} of aconitine in mice was 0.295 mg/kg SI, and that of the prepared decoction is 17.42 g/k.{{citation needed|date=September 2011}} A lethal dose of aconitine is 3–4 mg. Violdelphin is an anthocyanin, a type of plant pigment, found in the purplish blue flower of A. chinense.[11]Synonyms
References1. ^{{cite web|title=RHS Plant Selector - Aconitum carmichaelii 'Arendsii'|url=http://apps.rhs.org.uk/plantselector/plant?plantid=5231|accessdate=17 July 2013}} 2. ^{{cite web|title=RHS Plant Selector - Aconitum carmichaelii 'Kelmscott'|url=http://apps.rhs.org.uk/plantselector/plant?plantid=5762|accessdate=17 July 2013}} 3. ^1 {{cite book|title=RHS A-Z encyclopedia of garden plants|year=2008|publisher=Dorling Kindersley|location=United Kingdom|isbn=978-1405332965|pages=1136}} 4. ^Aconitum carmichaelii 5. ^{{cite journal | pmid = 7029146 | year = 1981 | last1 = Bisset | first1 = NG | title = Arrow poisons in China. Part II. Aconitum--botany, chemistry, and pharmacology | volume = 4 | issue = 3 | pages = 247–336 | journal = Journal of Ethnopharmacology | doi=10.1016/0378-8741(81)90001-5}} 6. ^1 The Extra Pharmacopoeia Martindale. Vol. 1, 24th edition. London: The Pharmaceutical Press, 1958, page 38. 7. ^1 {{EB1911|inline=1|wstitle=Aconite|volume=1|pages=151–152}} 8. ^1 {{cite journal |author =Chan TY |title=Aconite poisoning |journal=Clin Toxicol |volume=47 |issue=4 |pages=279–85 |date=April 2009 |pmid=19514874 |doi=10.1080/15563650902904407}} 9. ^{{cite journal |vauthors=Chyka PA, Seger D, Krenzelok EP, Vale JA |title=Position paper: Single-dose activated charcoal |journal=Clin Toxicol |volume=43 |issue=2 |pages=61–87 |year=2005 |pmid=15822758}} 10. ^{{cite journal |vauthors=Lin CC, Chan TY, Deng JF |title=Clinical features and management of herb-induced aconitine poisoning |journal=Ann Emerg Med |volume=43 |issue=5 |pages=574–9 |date=May 2004 |pmid=15111916 |doi=10.1016/j.annemergmed.2003.10.046}} 11. ^{{cite journal | doi = 10.1016/S0031-9422(00)89784-8| pmid = 7765001| title = The anthocyanin responsible for purplish blue flower colour of Aconitum chinense| journal = Phytochemistry| volume = 36| issue = 3| pages = 613-6| year = 1994| last1 = Takeda| first1 = Kosaku| last2 = Sato| first2 = Syuji| last3 = Kobayashi| first3 = Hiromitsu| last4 = Kanaitsuka| first4 = Yoko| last5 = Ueno| first5 = Mariko| last6 = Kinoshita| first6 = Takeshi| last7 = Tazaki| first7 = Hiroyuki| last8 = Fujimori| first8 = Takane}} External links
4 : Aconitum|Plants used in traditional Chinese medicine|Poisonous plants|Flora of China |
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