| 词条 | Actinin |
| 释义 |
Actinin is a microfilament protein. α-Actinin is necessary for the attachment of actin filaments to the Z-lines in skeletal muscle cells,[1] and to the dense bodies in smooth muscle cells.[2] The functional protein is an anti-parallel dimer, which cross-links the thin filaments in adjacent sarcomeres, and therefore coordinates contractions between sarcomeres in the horizontal axis. The non-sarcomeric α-actinins, encoded by ACTN1 and ACTN4, are widely expressed. ACTN2 expression is found in both cardiac and skeletal muscle, whereas ACTN3 is limited to the latter. Both ends of the rod-shaped α-actinin dimer contain actin-binding domains. Mutations in ACTN4 can cause the kidney disease focal segmental glomerulosclerosis (FSGS).[3] See also
References1. ^{{cite book|title=Ganong's Review of Medical Physiology, 24th Edition|year=2012|publisher=Lange (Tata McGraw Hill)|page=100}} 2. ^{{cite book|author1=Laszlo Szekeres|author2=Julius G. Papp|title=Pharmacology of Smooth Muscle|url=https://books.google.com/books?id=MWrvCAAAQBAJ&pg=PA18|date=6 December 2012|publisher=Springer Science & Business Media|isbn=978-3-642-78920-5|pages=17–18}} 3. ^{{cite book|author1=Richard P. Lifton|author2=Stefan Somlo|author3=Gerhard H. Giebisch|author4=Donald W. Seldin|title=Genetic Diseases of the Kidney|url=https://books.google.com/books?id=gXdlruzmqJsC&pg=PA117|date=25 February 2009|publisher=Academic Press|isbn=978-0-08-092427-4|pages=117–118}} External links
1 : EF-hand-containing proteins |
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