| 词条 | Methyldiazinol |
| 释义 |
| Verifiedfields = | Watchedfields = | verifiedrevid = | IUPAC_name = (5S,8R,9S,10S,13S,14S,17S)-10,13,17-Trimethylspiro[2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,3'-diazirine]-17-ol | image = Methyldiazirinol.svg | width = 225px | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = By mouth | class = Androgen; Anabolic steroid | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = | CAS_number = 2429-17-6 | CAS_supplemental = | ATC_prefix = | ATC_suffix = | ATC_supplemental = | PubChem = 112500385 | IUPHAR_ligand = | DrugBank_Ref = | DrugBank = | ChemSpiderID_Ref = | ChemSpiderID = 52084890 | UNII = 7AA03AP597 | KEGG = | ChEBI = | ChEMBL = | synonyms = Methyldiazirinol; 3,3-Azo-17α-methyl-5α-dihydrotestosterone; 3,3-Azo-17α-methyl-DHT; 3,3-Azo-17α-methyl-5α-androstan-17β-ol; 3-Azi-17α-methyl-5α-androstan-17β-ol | C=20 | H=32 | N=2 | O=1 | molecular_weight = 316.489 g/mol | SMILES = C[C@]12CCC3(C[C@@H]1CC[C@@H]4[C@@H]2CC[C@]5([C@H]4CC[C@]5(C)O)C)N=N3 | StdInChI_Ref = | StdInChI = LMNFACKYKJIJHJ-PHFHYRSDSA-N | StdInChIKey_Ref = | StdInChIKey = 1S/C20H32N2O/c1-17-10-11-20(21-22-20)12-13(17)4-5-14-15(17)6-8-18(2)16(14)7-9-19(18,3)23/h13-16,23H,4-12H2,1-3H3/t13-,14+,15-,16-,17-,18-,19-/m0/s1 }}Methyldiazinol (also known as 3,3-azo-17α-methyl-5α-dihydrotestosterone, 3-azi-17α-methyl-DHT, or 3,3-azo-17α-methyl-5α-androstan-17β-ol) is a synthetic and orally active androgen/anabolic steroid (AAS) which was never marketed.[1][2] It is a 17α-methylated derivative of dihydrotestosterone (DHT); specifically, it is the C3 azi (i.e., 3,3-azo) analogue of mestanolone (17α-methyl-DHT).[1][2] The drug has been found to possess a high ratio and dissociation of myotrophic to androgenic activity; relative to methyltestosterone, its ratio was 15 (3:0.2), among the highest observed.[1][2] See also
References1. ^1 2 {{cite book|author=Charles D. Kochakian|title=Anabolic-Androgenic Steroids|url=https://books.google.com/books?id=3-LrCAAAQBAJ&pg=PA385|date=6 December 2012|publisher=Springer Science & Business Media|isbn=978-3-642-66353-6|page=385|quote=Methyldiazinol: 3-Azi-17-methyl-5α-androstan-17β-ol: The 3-azi derivative of methandrostanolone was noted by CHURCH et al. (1965) to have a wide myotrophic:androgenic dissociation (3: 0.2) 15 relative to methyltestosterone orally, among the highest noted.}} {{Androgen receptor modulators}}{{Genito-urinary-drug-stub}}{{Steroid-stub}}2. ^1 2 {{cite journal|last1=Church|first1=Robert F. R.|last2=Kende|first2=Andrew S.|last3=Weiss|first3=Martin J.|title=Diazirines. I. Some Observations on the Scope of the Ammonia-Hydroxylamine-O-sulfonic Acid Diaziridine Synthesis. The Preparation of Certain Steroid Diaziridines and Diazirines|journal=Journal of the American Chemical Society|volume=87|issue=12|year=1965|pages=2665–2671|issn=0002-7863|doi=10.1021/ja01090a025}} 6 : Abandoned drugs|Alcohols|Androgens and anabolic steroids|Androstanes|Hepatotoxins|Diazirines |
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