| 词条 | Michael J. Krische |
| 释义 |
| name = Michael J. Krische | image = | image_size = | caption = | birth_date = September 1966 | birth_place = Burlingame, California | death_date = | death_place = | residence = Austin, TX | nationality = American | field = Chemist | work_institution = University of Texas at Austin | alma_mater = University of California, Berkeley Stanford University | doctoral_advisor = Barry M Trost | known_for = | prizes = }}Michael J. Krische (FRSC, FAAAS) is an American chemist and Robert A. Welch Chair in Science at the Department of Chemistry, University of Texas at Austin. Krische has pioneered a broad, new family of catalytic C-C bond formations that occur through the addition or redistribution of hydrogen. These processes merge the characteristics of catalytic hydrogenation and carbonyl addition, contributing to a departure from the use of stoichiometric organometallic reagents in chemical synthesis.[1][2][3][4][5][6] LifeKrische was born in 1966 in Burlingame, California, a city on the San Francisco peninsula. He is the son of Joseph Krische, a Gottschee German who immigrated to the USA in 1952 after a 7-year period in the Kapfenberg displaced persons camp following WWII. Education and careerMichael J. Krische obtained a B.S. degree in chemistry from the University of California, Berkeley (1989), where he performed research with Henry Rapoport. After one year abroad as a Fulbright Fellow, he initiated doctoral studies at Stanford University with Barry Trost as a Veatch Graduate Fellow. Following receipt of his Ph.D. degree (1996), he joined the laboratory of Nobel Laureate Jean-Marie Lehn at the Universite Louis Pasteur (now University of Strasbourg) as an NIH Post-Doctoral Fellow. In 1999, he joined the faculty at the University of Texas at Austin. Krische was promoted directly to the rank of full professor (2004), and shortly thereafter appointed the Robert A. Welch Chair in Science (2007). ResearchStereo- and site-selective methods for the byproduct-free modification of unprotected organic compounds that occur through the addition or redistribution of hydrogen are natural endpoints in the advancement of methods for efficient, green chemical synthesis. Krische has demonstrated hydrogenation or transfer hydrogenation of π-unsaturated reactants in the presence of C=X (X = O, NR) bonds delivers products of carbonyl or imine addition.[1][2][3][4] In related hydrogen auto-transfer reactions, alcohols served dually as reductants and carbonyl proelectrophiles, enabling direct, stereo- and site-selective conversion of lower alcohols to higher alcohols.[5][6] The Krische allylation exemplifies the latter class of C-C coupling.[6] Application of these methods in natural product total synthesis have been shown to increase step-economy.[7] For example, a concise total synthesis of swinholide A was achieved using diverse hydrogen-mediated C-C couplings.[8] Major awards
References1. ^1 {{Cite journal | doi=10.1021/jo061895m| pmid=17288361|title = Hydrogen-Mediated C−C Bond Formation: A Broad New Concept in Catalytic C−C Coupling1| journal=The Journal of Organic Chemistry| volume=72| issue=4| pages=1063–1072|year = 2007|last1 = Ngai|first1 = Ming-Yu| last2=Kong| first2=Jong-Rock| last3=Krische| first3=Michael J.| last4=Bickelhaupt| first4=F. Matthias| bibcode=2007JOCh...72.1134P}} 2. ^1 {{Cite journal | doi=10.1002/anie.200802938| pmid=19040235| pmc=2775511|title = Catalytic Carbonyl Addition through Transfer Hydrogenation: A Departure from Preformed Organometallic Reagents| journal=Angewandte Chemie International Edition| volume=48| issue=1| pages=34–46|year = 2009|last1 = Bower|first1 = John F.| last2=Kim| first2=In Su| last3=Patman| first3=Ryan L.| last4=Krische| first4=Michael J.}} 3. ^1 {{Cite journal | doi=10.1021/op200195m| pmid=22125398| pmc=3224080|title = Unlocking Hydrogenation for C–C Bond Formation: A Brief Overview of Enantioselective Methods| journal=Organic Process Research & Development| volume=15| issue=6| pages=1236–1242|year = 2011|last1 = Hassan|first1 = Abbas| last2=Krische| first2=Michael J.}} 4. ^1 {{Cite journal |doi = 10.1016/j.cogsc.2017.06.006|pmid = 29726550|pmc = 5926236|title = Reductive C–C coupling via hydrogenation and transfer hydrogenation: Departure from stoichiometric metals in carbonyl addition|journal = Current Opinion in Green and Sustainable Chemistry|volume = 7|pages = 1–5|year = 2017|last1 = Roane|first1 = James|last2 = Holmes|first2 = Michael|last3 = Krische|first3 = Michael J.}} 5. ^1 {{Cite journal |doi = 10.1002/anie.201403873|pmid = 25056771|pmc = 4150357|title = Catalytic Enantioselective CH Functionalization of Alcohols by Redox-Triggered Carbonyl Addition: Borrowing Hydrogen, Returning Carbon|journal = Angewandte Chemie International Edition|volume = 53|issue = 35|pages = 9142–9150|year = 2014|last1 = Ketcham|first1 = John M.|last2 = Shin|first2 = Inji|last3 = Montgomery|first3 = T. Patrick|last4 = Krische|first4 = Michael J.|last5 = Gauss|first5 = J.|bibcode = 2012AnChe..51.3695M}} 6. ^1 2 {{Cite journal |doi = 10.1021/acs.accounts.7b00308|pmid = 28792731|pmc = 5641472|title = Catalytic Enantioselective Carbonyl Allylation and Propargylation via Alcohol-Mediated Hydrogen Transfer: Merging the Chemistry of Grignard and Sabatier|journal = Accounts of Chemical Research|volume = 50|issue = 9|pages = 2371–2380|year = 2017|last1 = Kim|first1 = Seung Wook|last2 = Zhang|first2 = Wandi|last3 = Krische|first3 = Michael J.}} 7. ^{{Cite journal | doi=10.1021/jacs.6b02019| pmid=27113543| pmc=4871165|title = Enantioselective Alcohol C–H Functionalization for Polyketide Construction: Unlocking Redox-Economy and Site-Selectivity for Ideal Chemical Synthesis| journal=Journal of the American Chemical Society| volume=138| issue=17| pages=5467–5478|year = 2016|last1 = Feng|first1 = Jiajie| last2=Kasun| first2=Zachary A.| last3=Krische| first3=Michael J.}} 8. ^{{Cite journal | doi=10.1021/jacs.6b10645| pmid=27779393| pmc=5096380|title = Total Synthesis of Swinholide A: An Exposition in Hydrogen-Mediated C–C Bond Formation| journal=Journal of the American Chemical Society| volume=138| issue=43| pages=14246–14249|year = 2016|last1 = Shin|first1 = Inji| last2=Hong| first2=Suckchang| last3=Krische| first3=Michael J.}} External Links
13 : 1966 births|Living people|People from Burlingame, California|20th-century American chemists|21st-century American chemists|American people of German descent|University of California, Berkeley alumni|Humboldt Research Award recipients|Fellows of the American Association for the Advancement of Science|Sloan Fellows|Fulbright Scholars|University of Texas at Austin faculty|Stanford University alumni |
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