| 词条 | MicL sRNA |
| 释义 |
| Name = MicL sRNA | image = RF02654.svg | width = | caption = Predicted secondary structure and sequence conservation of MicL small RNA | Symbol = | AltSymbols = | Rfam = RF02654 | miRBase = | miRBase_family = | RNA_type = | Tax_domain = Bacteria | GO = {{GO|0030371}} | SO = {{SO|0000370}} | CAS_number = | EntrezGene = | HGNCid = | OMIM = | PDB = | RefSeq = | Chromosome = | Arm = | Band = | LocusSupplementaryData = }}MicL RNA (mRNA-interfering complementary RNA regulator of Lpp) is a σ E transcription factor-dependent small non-coding RNA. It was discovered in E. coli. Together with MicA and RybB sRNAs, MicL sRNA down-regulates the synthesis of abundant outer membrane proteins in response to stress. MicL specifically targets mRNA of lipoprotein Lpp, preventing its translation.[1] References1. ^{{Cite journal|last=Guo|first=Monica S.|last2=Updegrove|first2=Taylor B.|last3=Gogol|first3=Emily B.|last4=Shabalina|first4=Svetlana A.|last5=Gross|first5=Carol A.|last6=Storz|first6=Gisela|date=2014-07-15|title=MicL, a new σE-dependent sRNA, combats envelope stress by repressing synthesis of Lpp, the major outer membrane lipoprotein|journal=Genes & Development|volume=28|issue=14|pages=1620–1634|doi=10.1101/gad.243485.114|issn=1549-5477|pmc=4102768|pmid=25030700}} {{genetics-stub}} 3 : Non-coding RNA|RNA|RNA-binding proteins |
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