| 释义 |
- References
- External links
- Further reading
{{Infobox_gene}}The activin A receptor also known as ACVR1C or ALK-7 is a protein that in humans is encoded by the ACVR1C gene.[1] ACVR1C is a type I receptor for the TGFB family of signaling molecules.[1] ACVR1C transduces signals of Nodal. Nodal binds to ACVR2B and then forms a complex with ACVR1C. These go on to recruit the R-SMADs SMAD2 or SMAD3.[2] Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD family transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors.[1] References1. ^1 2 {{cite journal | vauthors = Bondestam J, Huotari MA, Morén A, Ustinov J, Kaivo-Oja N, Kallio J, Horelli-Kuitunen N, Aaltonen J, Fujii M, Moustakas A, Ten Dijke P, Otonkoski T, Ritvos O | title = cDNA cloning, expression studies and chromosome mapping of human type I serine/threonine kinase receptor ALK7 (ACVR1C) | journal = Cytogenet. Cell Genet. | volume = 95 | issue = 3–4 | pages = 157–62 | year = 2001 | pmid = 12063393 | doi = 10.1159/000059339| url = }}
2. ^{{cite journal | vauthors = Inman GJ, Nicolás FJ, Callahan JF, Harling JD, Gaster LM, Reith AD, Laping NJ, Hill CS | title = SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7 | journal = Mol. Pharmacol. | volume = 62 | issue = 1 | pages = 65–74 |date=July 2002 | pmid = 12065756 | doi = 10.1124/mol.62.1.65| url = }}
{{Clear}}External links- {{UCSC gene info|ACVR1C}}
Further reading{{refbegin | 2}}- {{cite journal |vauthors =Carlsson LM, Jacobson P, Walley A |title=ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic disease |journal=Biochem. Biophys. Res. Commun. |volume=382 |issue= 2 |pages= 309–14 |year= 2009 |pmid= 19275893 |doi= 10.1016/j.bbrc.2009.03.014 |pmc=2681012 |display-authors=etal}}
- {{cite journal |vauthors =Reissmann E, Jörnvall H, Blokzijl A |title=The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development |journal=Genes Dev. |volume=15 |issue= 15 |pages= 2010–22 |year= 2001 |pmid= 11485994 |doi= 10.1101/gad.201801 |pmc=312747 |display-authors=etal}}
- {{cite journal |vauthors =Andersson O, Korach-Andre M, Reissmann E |title=Growth/differentiation factor 3 signals through ALK7 and regulates accumulation of adipose tissue and diet-induced obesity |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=105 |issue= 20 |pages= 7252–6 |year= 2008 |pmid= 18480259 |doi= 10.1073/pnas.0800272105 |pmc=2438236 |display-authors=etal}}
- {{cite journal |vauthors =Watanabe R, Shen ZP, Tsuda K, Yamada Y |title=Insulin gene is a target in activin receptor-like kinase 7 signaling pathway in pancreatic beta-cells |journal=Biochem. Biophys. Res. Commun. |volume=377 |issue= 3 |pages= 867–72 |year= 2008 |pmid= 18951876 |doi= 10.1016/j.bbrc.2008.10.074 }}
- {{cite journal |vauthors =Roberts HJ, Hu S, Qiu Q |title=Identification of novel isoforms of activin receptor-like kinase 7 (ALK7) generated by alternative splicing and expression of ALK7 and its ligand, Nodal, in human placenta |journal=Biol. Reprod. |volume=68 |issue= 5 |pages= 1719–26 |year= 2003 |pmid= 12606401 |doi= 10.1095/biolreprod.102.013045 |display-authors=etal}}
- {{cite journal |vauthors =Hillier LW, Graves TA, Fulton RS |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4 |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 |display-authors=etal}}
- {{cite journal |vauthors =Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 |pmc=528928 |display-authors=etal}}
- {{cite journal |vauthors =Xu G, Zhong Y, Munir S |title=Nodal induces apoptosis and inhibits proliferation in human epithelial ovarian cancer cells via activin receptor-like kinase 7 |journal=J. Clin. Endocrinol. Metab. |volume=89 |issue= 11 |pages= 5523–34 |year= 2004 |pmid= 15531507 |doi= 10.1210/jc.2004-0893 |display-authors=etal}}
- {{cite journal |vauthors =Xu G, Bernaudo S, Fu G |title=Cyclin G2 is degraded through the ubiquitin-proteasome pathway and mediates the antiproliferative effect of activin receptor-like kinase 7 |journal=Mol. Biol. Cell |volume=19 |issue= 11 |pages= 4968–79 |year= 2008 |pmid= 18784254 |doi= 10.1091/mbc.E08-03-0259 |pmc=2575152 |display-authors=etal}}
- {{cite journal |vauthors =Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241 |display-authors=etal}}
- {{cite journal |vauthors =Kim BC, van Gelder H, Kim TA |title=Activin receptor-like kinase-7 induces apoptosis through activation of MAPKs in a Smad3-dependent mechanism in hepatoma cells |journal=J. Biol. Chem. |volume=279 |issue= 27 |pages= 28458–65 |year= 2004 |pmid= 15107418 |doi= 10.1074/jbc.M313277200 |display-authors=etal}}
- {{cite journal |vauthors =Munir S, Xu G, Wu Y |title=Nodal and ALK7 inhibit proliferation and induce apoptosis in human trophoblast cells |journal=J. Biol. Chem. |volume=279 |issue= 30 |pages= 31277–86 |year= 2004 |pmid= 15150278 |doi= 10.1074/jbc.M400641200 |display-authors=etal}}
- {{cite journal |vauthors =Xu G, Zhou H, Wang Q |title=Activin receptor-like kinase 7 induces apoptosis through up-regulation of Bax and down-regulation of Xiap in normal and malignant ovarian epithelial cell lines |journal=Mol. Cancer Res. |volume=4 |issue= 4 |pages= 235–46 |year= 2006 |pmid= 16603637 |doi= 10.1158/1541-7786.MCR-05-0174 |display-authors=etal}}
- {{cite journal |vauthors =Tsuchida K, Nakatani M, Yamakawa N |title=Activin isoforms signal through type I receptor serine/threonine kinase ALK7 |journal=Mol. Cell. Endocrinol. |volume=220 |issue= 1–2 |pages= 59–65 |year= 2004 |pmid= 15196700 |doi= 10.1016/j.mce.2004.03.009 |display-authors=etal}}
{{refend}}{{TGF beta signaling}}{{Serine/threonine-specific protein kinases}}{{Enzymes}}{{TGFβ receptor superfamily modulators}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{DEFAULTSORT:Acvr1c}} 5 : GS domain|TS domain|S/T domain|Human proteins|EC 2.7.11 |