| 词条 | MicroDNA |
| 释义 |
MicroDNA is the most abundant subtype of Extrachromosomal Circular DNA (eccDNA) in humans.[1][2][3] They are 200-400 base pairs in length and are enriched in genic sequences and CpG-islands. BiogenesisThe formation of microDNA has been tied to the DNA mismatch repair pathway.[2] CancerMicroDNA formation have been tied to chemotherapeutic treatment.[4] Further, microDNA have been detected in the bloodstream of cancer patients and may become a biomarker for the detection of cancer.[5] See also
References1. ^{{cite journal | vauthors = Shibata Y, Kumar P, Layer R, Willcox S, Gagan JR, Griffith JD, Dutta A | title = Extrachromosomal microDNAs and chromosomal microdeletions in normal tissues | journal = Science | volume = 336 | issue = 6077 | pages = 82–6 | date = April 2012 | pmid = 22403181 | pmc = 3703515 | doi = 10.1126/science.1213307 }} {{molecular-biology-stub}}2. ^1 {{cite journal | vauthors = Dillon LW, et al.| title = Production of Extrachromosomal MicroDNAs Is Linked to Mismatch Repair Pathways and Transcriptional Activity | journal = Cell Reports | volume = 11 | issue = 11 | pages = 1749–1759 | date = June 2015 | pmid = 26051933 | pmc = 4481157 | doi = 10.1016/j.celrep.2015.05.020}} 3. ^{{cite journal | vauthors = Paulsen T, Kumar P, Koseoglu MM, Dutta A | title = Discoveries of Extrachromosomal Circles of DNA in Normal and Tumor Cells | journal = Trends in Genetics | volume = 34 | issue = 4 | pages = 270–278 | date = April 2018 | pmid = 29329720 | pmc = 5881399 | doi = 10.1016/j.tig.2017.12.010 }} 4. ^{{cite journal | vauthors = Mehanna P, Gagné V, Lajoie M, Spinella JF, St-Onge P, Sinnett D, Brukner I, Krajinovic M | title = Characterization of the microDNA through the response to chemotherapeutics in lymphoblastoid cell lines | journal = PLOS One | volume = 12 | issue = 9 | pages = e0184365 | year = 2017 | pmid = 28877255 | pmc = 5587290 | doi = 10.1371/journal.pone.0184365 }} 5. ^{{cite journal | vauthors = Kumar P, Dillon LW, Shibata Y, Jazaeri AA, Jones DR, Dutta A | title = Normal and Cancerous Tissues Release Extrachromosomal Circular DNA (eccDNA) into the Circulation | journal = Molecular Cancer Research | volume = 15 | issue = 9 | pages = 1197–1205 | date = September 2017 | pmid = 28550083 | pmc = 5581709 | doi = 10.1158/1541-7786.MCR-17-0095 }} 1 : DNA |
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