| 释义 |
- Function
- References
- Further reading
{{Infobox_gene}}MicroRNA 124-3 is a protein that in humans is encoded by the MIR124-3 gene. [1]FunctionMicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. References 1. ^{{cite web| title = Entrez Gene: MicroRNA 124-3| url = https://www.ncbi.nlm.nih.gov/gene/406909| accessdate = 2018-09-12}}
Further reading {{refbegin | 30em}}- {{cite journal |vauthors=Furuta M, Kozaki KI, Tanaka S, Arii S, Imoto I, Inazawa J |title=miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma |journal=Carcinogenesis |volume=31 |issue=5 |pages=766–76 |date=May 2010 |pmid=19843643 |doi=10.1093/carcin/bgp250 |url=}}
- {{cite journal |vauthors=Hunt S, Jones AV, Hinsley EE, Whawell SA, Lambert DW |title=MicroRNA-124 suppresses oral squamous cell carcinoma motility by targeting ITGB1 |journal=FEBS Lett. |volume=585 |issue=1 |pages=187–92 |date=January 2011 |pmid=21112327 |doi=10.1016/j.febslet.2010.11.038 |url=}}
- {{cite journal |vauthors=Kitano K, Watanabe K, Emoto N, Kage H, Hamano E, Nagase T, Sano A, Murakawa T, Nakajima J, Goto A, Fukayama M, Yatomi Y, Ohishi N, Takai D |title=CpG island methylation of microRNAs is associated with tumor size and recurrence of non-small-cell lung cancer |journal=Cancer Sci. |volume=102 |issue=12 |pages=2126–31 |date=December 2011 |pmid=21917081 |doi=10.1111/j.1349-7006.2011.02101.x |url=}}
- {{cite journal |vauthors=Gebauer K, Peters I, Dubrowinskaja N, Hennenlotter J, Abbas M, Scherer R, Tezval H, Merseburger AS, Stenzl A, Kuczyk MA, Serth J |title=Hsa-mir-124-3 CpG island methylation is associated with advanced tumours and disease recurrence of patients with clear cell renal cell carcinoma |journal=Br. J. Cancer |volume=108 |issue=1 |pages=131–8 |date=January 2013 |pmid=23321515 |pmc=3553529 |doi=10.1038/bjc.2012.537 |url=}}
- {{cite journal |vauthors=Wang P, Chen L, Zhang J, Chen H, Fan J, Wang K, Luo J, Chen Z, Meng Z, Liu L |title=Methylation-mediated silencing of the miR-124 genes facilitates pancreatic cancer progression and metastasis by targeting Rac1 |journal=Oncogene |volume=33 |issue=4 |pages=514–24 |date=January 2014 |pmid=23334332 |doi=10.1038/onc.2012.598 |url=}}
- {{cite journal |vauthors=Xu X, Li S, Lin Y, Chen H, Hu Z, Mao Y, Xu X, Wu J, Zhu Y, Zheng X, Luo J, Xie L |title=MicroRNA-124-3p inhibits cell migration and invasion in bladder cancer cells by targeting ROCK1 |journal=J Transl Med |volume=11 |issue= |pages=276 |date=November 2013 |pmid=24180482 |pmc=4228407 |doi=10.1186/1479-5876-11-276 |url=}}
- {{cite journal |vauthors=Ben Gacem R, Ben Abdelkrim O, Ziadi S, Ben Dhiab M, Trimeche M |title=Methylation of miR-124a-1, miR-124a-2, and miR-124a-3 genes correlates with aggressive and advanced breast cancer disease |journal=Tumour Biol. |volume=35 |issue=5 |pages=4047–56 |date=May 2014 |pmid=24375250 |doi=10.1007/s13277-013-1530-4 |url=}}
- {{cite journal |vauthors=Mi J, Chen D, Wu M, Wang W, Gao H |title=Study of the effect of miR‑124 and the SOX9 target gene in Hirschsprung's disease |journal=Mol Med Rep |volume=9 |issue=5 |pages=1839–43 |date=May 2014 |pmid=24604230 |doi=10.3892/mmr.2014.2022 |url=}}
- {{cite journal |vauthors=Leung LY, Chan CP, Leung YK, Jiang HL, Abrigo JM, Wang de F, Chung JS, Rainer TH, Graham CA |title=Comparison of miR-124-3p and miR-16 for early diagnosis of hemorrhagic and ischemic stroke |journal=Clin. Chim. Acta |volume=433 |issue= |pages=139–44 |date=June 2014 |pmid=24650689 |doi=10.1016/j.cca.2014.03.007 |url=}}
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