| 释义 |
- Function
- References
- Further reading
{{Infobox_gene}}MicroRNA 141 is a protein that in humans is encoded by the MIR141 gene. [1]FunctionmicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. References 1. ^{{cite web| title = Entrez Gene: MicroRNA 141| url = https://www.ncbi.nlm.nih.gov/gene/406933| accessdate = 2018-03-23}}
Further reading {{refbegin | 30em}}- {{cite journal |vauthors=Du Y, Xu Y, Ding L, Yao H, Yu H, Zhou T, Si J |title=Down-regulation of miR-141 in gastric cancer and its involvement in cell growth |journal=J. Gastroenterol. |volume=44 |issue=6 |pages=556–61 |date=2009 |pmid=19363643 |doi=10.1007/s00535-009-0037-7 |url=}}
- {{cite journal |vauthors=Hu M, Xia M, Chen X, Lin Z, Xu Y, Ma Y, Su L |title=MicroRNA-141 regulates Smad interacting protein 1 (SIP1) and inhibits migration and invasion of colorectal cancer cells |journal=Dig. Dis. Sci. |volume=55 |issue=8 |pages=2365–72 |date=August 2010 |pmid=19830559 |doi=10.1007/s10620-009-1008-9 |url=}}
- {{cite journal |vauthors=Zhang L, Deng T, Li X, Liu H, Zhou H, Ma J, Wu M, Zhou M, Shen S, Li X, Niu Z, Zhang W, Shi L, Xiang B, Lu J, Wang L, Li D, Tang H, Li G |title=microRNA-141 is involved in a nasopharyngeal carcinoma-related genes network |journal=Carcinogenesis |volume=31 |issue=4 |pages=559–66 |date=April 2010 |pmid=20053927 |doi=10.1093/carcin/bgp335 |url=}}
- {{cite journal |vauthors=Vrba L, Jensen TJ, Garbe JC, Heimark RL, Cress AE, Dickinson S, Stampfer MR, Futscher BW |title=Role for DNA methylation in the regulation of miR-200c and miR-141 expression in normal and cancer cells |journal=PLoS ONE |volume=5 |issue=1 |pages=e8697 |date=January 2010 |pmid=20084174 |pmc=2805718 |doi=10.1371/journal.pone.0008697 |url=}}
- {{cite journal |vauthors=Uhlmann S, Zhang JD, Schwäger A, Mannsperger H, Riazalhosseini Y, Burmester S, Ward A, Korf U, Wiemann S, Sahin O |title=miR-200bc/429 cluster targets PLCgamma1 and differentially regulates proliferation and EGF-driven invasion than miR-200a/141 in breast cancer |journal=Oncogene |volume=29 |issue=30 |pages=4297–306 |date=July 2010 |pmid=20514023 |doi=10.1038/onc.2010.201 |url=}}
- {{cite journal |vauthors=Banaudha K, Kaliszewski M, Korolnek T, Florea L, Yeung ML, Jeang KT, Kumar A |title=MicroRNA silencing of tumor suppressor DLC-1 promotes efficient hepatitis C virus replication in primary human hepatocytes |journal=Hepatology |volume=53 |issue=1 |pages=53–61 |date=January 2011 |pmid=20967756 |doi=10.1002/hep.24016 |url=}}
- {{cite journal |vauthors=Ho BC, Yu SL, Chen JJ, Chang SY, Yan BS, Hong QS, Singh S, Kao CL, Chen HY, Su KY, Li KC, Cheng CL, Cheng HW, Lee JY, Lee CN, Yang PC |title=Enterovirus-induced miR-141 contributes to shutoff of host protein translation by targeting the translation initiation factor eIF4E |journal=Cell Host Microbe |volume=9 |issue=1 |pages=58–69 |date=January 2011 |pmid=21238947 |doi=10.1016/j.chom.2010.12.001 |url=}}
- {{cite journal |vauthors=Imanaka Y, Tsuchiya S, Sato F, Shimada Y, Shimizu K, Tsujimoto G |title=MicroRNA-141 confers resistance to cisplatin-induced apoptosis by targeting YAP1 in human esophageal squamous cell carcinoma |journal=J. Hum. Genet. |volume=56 |issue=4 |pages=270–6 |date=April 2011 |pmid=21289630 |doi=10.1038/jhg.2011.1 |url=}}
- {{cite journal |vauthors=Cheng H, Zhang L, Cogdell DE, Zheng H, Schetter AJ, Nykter M, Harris CC, Chen K, Hamilton SR, Zhang W |title=Circulating plasma MiR-141 is a novel biomarker for metastatic colon cancer and predicts poor prognosis |journal=PLoS ONE |volume=6 |issue=3 |pages=e17745 |date=March 2011 |pmid=21445232 |pmc=3060165 |doi=10.1371/journal.pone.0017745 |url=}}
{{refend}}{{gene-12-stub}}{{NLM content}} |