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词条 Adapter molecule crk
释义

  1. Function

  2. Interactions

  3. See also

  4. References

  5. Further reading

  6. External links

{{Infobox_gene}}Adapter molecule crk also known as proto-oncogene c-Crk is a protein that in humans is encoded by the CRK gene.[1]

The CRK protein participates in the Reelin signaling cascade downstream of DAB1.[2][3]

Function

Adapter molecule crk is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. This protein has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.[4]

Crk together with CrkL participates in the Reelin signaling cascade downstream of DAB1.[2][3]

v-Crk, a transforming oncoprotein from avian sarcoma viruses, is a fusion of viral "gag" protein with the SH2 and SH3 domains of cellular Crk.[5] The name Crk is from "CT10 Regulator of Kinase" where CT10 is the avian virus from which was isolated a protein, lacking kinase domains, but capable of stimulating phosphorylation of tyrosines in cells.[6]

Crk should not be confused with Src, which also has cellular (c-Src) and viral (v-Src) forms and is involved in some of the same signaling pathways but is a protein tyrosine-kinase.

Interactions

CRK (gene) has been shown to interact with:

{{div col|colwidth=20em}}
  • BCAR1,[7][8][9][10][11][12][13][14][15]
  • Cbl gene,[16][17]
  • Dock180,[20][9][10][18][19]
  • EPS15,[20]
  • Epidermal growth factor receptor,[21][22]
  • Grb2,[23][24][25]
  • IRS4,[26][27]
  • MAP4K1,[28][29][30]
  • MAPK8,[31]
  • NEDD9,[32][33]
  • PDGFRA,[39][34]
  • PDGFRB,[35]
  • PTK2,[9][12]
  • Paxillin[12][36]
  • RAPGEF1,[37]
  • RICS,[38][39]
  • SH3KBP1,[40] and
  • SOS1.[25]
{{Div col end}}

See also

  • CrkL, "Crk-like" protein

References

1. ^{{cite journal| doi = 10.1073/pnas.87.7.2638|vauthors=Mayer BJ, Hanafusa H | title=Association of the v-crk oncogene product with phosphotyrosine-containing proteins and protein kinase activity. | journal = Proc Natl Acad Sci U S A | year = 1990 | volume= 87 | issue = 7 | pages = 2638–42 | pmid = 1690891 | pmc = 53745 }}
2. ^1 {{cite journal |vauthors=Matsuki T, Pramatarova A, Howell BW | title = Reduction of Crk and CrkL expression blocks reelin-induced dendritogenesis | journal = J. Cell Sci. | volume = 121 | issue = Pt 11 | pages = 1869–75 |date=June 2008| pmid = 18477607 | pmc = 2430739 | doi = 10.1242/jcs.027334 }}
3. ^1 {{cite journal |vauthors=Park TJ, Curran T | title = Crk and Crk-like play essential overlapping roles downstream of disabled-1 in the Reelin pathway | journal = J. Neurosci. | volume = 28 | issue = 50 | pages = 13551–62 |date=December 2008| pmid = 19074029 | pmc = 2628718 | doi = 10.1523/JNEUROSCI.4323-08.2008 }}
4. ^{{Cite web| title = Entrez Gene: CRK v-crk sarcoma virus CT10 oncogene homolog (avian)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1398}}
5. ^{{cite journal |title=Direct Binding of C-terminal Region of p130Graphic to SH2 and SH3 Domains of Src Kinase |author1=Tetsuya Nakamoto |author2=Ryuichi Sakai |author3=Keiya Ozawa |author4=Yoshio Yazaki |author5=Hisamaru Hirai |journal=J. Biol. Chem.|year=1996 |volume=271|pages=8959–8965| doi=10.1074/jbc.271.15.8959 |pmid=8621540}}
6. ^{{cite journal |vauthors=Mayer BJ, Hamaguchi M, Hanafusa H | title = A novel viral oncogene with structural similarity to phospholipase C | journal = Nature | volume = 332 | issue = 6161 | pages = 272–5 |date=March 1988| pmid = 2450282 | doi = 10.1038/332272a0 }}
7. ^{{cite journal |vauthors=Zhou B, Liu L, Reddivari M, Zhang XA | title = The palmitoylation of metastasis suppressor KAI1/CD82 is important for its motility- and invasiveness-inhibitory activity | journal = Cancer Res. | volume = 64 | issue = 20 | pages = 7455–63 | year = 2004 | pmid = 15492270 | doi = 10.1158/0008-5472.CAN-04-1574 }}
8. ^{{cite journal |vauthors=Di Stefano P, Cabodi S, Boeri Erba E, Margaria V, Bergatto E, Giuffrida MG, Silengo L, Tarone G, Turco E, Defilippi P | title = P130Cas-associated protein (p140Cap) as a new tyrosine-phosphorylated protein involved in cell spreading | journal = Mol. Biol. Cell | volume = 15 | issue = 2 | pages = 787–800 | year = 2004 | pmid = 14657239 | pmc = 329393 | doi = 10.1091/mbc.E03-09-0689 }}
9. ^1 2 {{cite journal |vauthors=Hsia DA, Mitra SK, Hauck CR, Streblow DN, Nelson JA, Ilic D, Huang S, Li E, Nemerow GR, Leng J, Spencer KS, Cheresh DA, Schlaepfer DD | title = Differential regulation of cell motility and invasion by FAK | journal = J. Cell Biol. | volume = 160 | issue = 5 | pages = 753–67 | year = 2003 | pmid = 12615911 | pmc = 2173366 | doi = 10.1083/jcb.200212114 }}
10. ^1 {{cite journal |vauthors=Gu J, Sumida Y, Sanzen N, Sekiguchi K | title = Laminin-10/11 and fibronectin differentially regulate integrin-dependent Rho and Rac activation via p130(Cas)-CrkII-DOCK180 pathway | journal = J. Biol. Chem. | volume = 276 | issue = 29 | pages = 27090–7 | year = 2001 | pmid = 11369773 | doi = 10.1074/jbc.M102284200 }}
11. ^{{cite journal |vauthors=Garton AJ, Tonks NK | title = Regulation of fibroblast motility by the protein tyrosine phosphatase PTP-PEST | journal = J. Biol. Chem. | volume = 274 | issue = 6 | pages = 3811–8 | year = 1999 | pmid = 9920935 | doi = 10.1074/jbc.274.6.3811}}
12. ^1 2 {{cite journal |vauthors=Angers-Loustau A, Côté JF, Charest A, Dowbenko D, Spencer S, Lasky LA, Tremblay ML | title = Protein tyrosine phosphatase-PEST regulates focal adhesion disassembly, migration, and cytokinesis in fibroblasts | journal = J. Cell Biol. | volume = 144 | issue = 5 | pages = 1019–31 | year = 1999 | pmid = 10085298 | pmc = 2148201 | doi = 10.1083/jcb.144.5.1019}}
13. ^{{cite journal |vauthors=Qiu W, Cobb RR, Scholz W | title = Inhibition of p130cas tyrosine phosphorylation by calyculin A | journal = J. Leukoc. Biol. | volume = 63 | issue = 5 | pages = 631–5 | year = 1998 | pmid = 9581808 | doi = }}
14. ^{{cite journal |vauthors=Blaukat A, Ivankovic-Dikic I, Grönroos E, Dolfi F, Tokiwa G, Vuori K, Dikic I | title = Adaptor proteins Grb2 and Crk couple Pyk2 with activation of specific mitogen-activated protein kinase cascades | journal = J. Biol. Chem. | volume = 274 | issue = 21 | pages = 14893–901 | year = 1999 | pmid = 10329689 | doi = 10.1074/jbc.274.21.14893}}
15. ^{{cite journal |vauthors=Wang JF, Park IW, Groopman JE | title = Stromal cell-derived factor-1alpha stimulates tyrosine phosphorylation of multiple focal adhesion proteins and induces migration of hematopoietic progenitor cells: roles of phosphoinositide-3 kinase and protein kinase C | journal = Blood | volume = 95 | issue = 8 | pages = 2505–13 | year = 2000 | pmid = 10753828 | doi = }}
16. ^{{cite journal |vauthors=Gesbert F, Garbay C, Bertoglio J | title = Interleukin-2 stimulation induces tyrosine phosphorylation of p120-Cbl and CrkL and formation of multimolecular signaling complexes in T lymphocytes and natural killer cells | journal = J. Biol. Chem. | volume = 273 | issue = 7 | pages = 3986–93 | year = 1998 | pmid = 9461587 | doi = 10.1074/jbc.273.7.3986}}
17. ^{{cite journal |vauthors=Husson H, Mograbi B, Schmid-Antomarchi H, Fischer S, Rossi B | title = CSF-1 stimulation induces the formation of a multiprotein complex including CSF-1 receptor, c-Cbl, PI 3-kinase, Crk-II and Grb2 | journal = Oncogene | volume = 14 | issue = 19 | pages = 2331–8 | year = 1997 | pmid = 9178909 | doi = 10.1038/sj.onc.1201074 }}
18. ^{{cite journal |vauthors=Nishihara H, Kobayashi S, Hashimoto Y, Ohba F, Mochizuki N, Kurata T, Nagashima K, Matsuda M | title = Non-adherent cell-specific expression of DOCK2, a member of the human CDM-family proteins | journal = Biochim. Biophys. Acta | volume = 1452 | issue = 2 | pages = 179–87 | year = 1999 | pmid = 10559471 | doi = 10.1016/S0167-4889(99)00133-0}}
19. ^{{cite journal |vauthors=Hasegawa H, Kiyokawa E, Tanaka S, Nagashima K, Gotoh N, Shibuya M, Kurata T, Matsuda M | title = DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane | journal = Mol. Cell. Biol. | volume = 16 | issue = 4 | pages = 1770–6 | year = 1996 | pmid = 8657152 | pmc = 231163 | doi = }}
20. ^{{cite journal |vauthors=Schumacher C, Knudsen BS, Ohuchi T, Di Fiore PP, Glassman RH, Hanafusa H | title = The SH3 domain of Crk binds specifically to a conserved proline-rich motif in Eps15 and Eps15R | journal = J. Biol. Chem. | volume = 270 | issue = 25 | pages = 15341–7 | year = 1995 | pmid = 7797522 | doi = 10.1074/jbc.270.25.15341}}
21. ^9614078 {{cite journal |vauthors=Schulze WX, Deng L, Mann M | title = Phosphotyrosine interactome of the ErbB-receptor kinase family | journal = Mol. Syst. Biol. | volume = 1 | issue = 1| pages = 2005.0008 | year = 2005 | pmid = 16729043 | pmc = 1681463 | doi = 10.1038/msb4100012}}
22. ^{{cite journal |vauthors=Hashimoto Y, Katayama H, Kiyokawa E, Ota S, Kurata T, Gotoh N, Otsuka N, Shibata M, Matsuda M | title = Phosphorylation of CrkII adaptor protein at tyrosine 221 by epidermal growth factor receptor | journal = J. Biol. Chem. | volume = 273 | issue = 27 | pages = 17186–91 | year = 1998 | pmid = 9642287 | doi = 10.1074/jbc.273.27.17186}}
23. ^{{cite journal |vauthors=Riordan SM, Lidder S, Williams R, Skouteris GG | title = The beta-subunit of the hepatocyte growth factor/scatter factor (HGF/SF) receptor phosphorylates and associates with CrkII: expression of CrkII enhances HGF/SF-induced mitogenesis | journal = Biochem. J. | volume = 350 | issue = 3| pages = 925–32 | year = 2000 | pmid = 10970810 | pmc = 1221328 | doi = 10.1042/0264-6021:3500925}}
24. ^1 {{cite journal |vauthors=Matsuda M, Ota S, Tanimura R, Nakamura H, Matuoka K, Takenawa T, Nagashima K, Kurata T | title = Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins | journal = J. Biol. Chem. | volume = 271 | issue = 24 | pages = 14468–72 | year = 1996 | pmid = 8662907 | doi = 10.1074/jbc.271.24.14468}}
25. ^1 {{cite journal |vauthors=Okada S, Pessin JE | title = Interactions between Src homology (SH) 2/SH3 adapter proteins and the guanylnucleotide exchange factor SOS are differentially regulated by insulin and epidermal growth factor | journal = J. Biol. Chem. | volume = 271 | issue = 41 | pages = 25533–8 | year = 1996 | pmid = 8810325 | doi = 10.1074/jbc.271.41.25533}}
26. ^{{cite journal |vauthors=Karas M, Koval AP, Zick Y, LeRoith D | title = The insulin-like growth factor I receptor-induced interaction of insulin receptor substrate-4 and Crk-II | journal = Endocrinology | volume = 142 | issue = 5 | pages = 1835–40 | year = 2001 | pmid = 11316748 | doi = 10.1210/en.142.5.1835}}
27. ^{{cite journal |vauthors=Koval AP, Karas M, Zick Y, LeRoith D | title = Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction | journal = J. Biol. Chem. | volume = 273 | issue = 24 | pages = 14780–7 | year = 1998 | pmid = 9614078 | doi = 10.1074/jbc.273.24.14780}}
28. ^{{cite journal |vauthors=Oehrl W, Kardinal C, Ruf S, Adermann K, Groffen J, Feng GS, Blenis J, Tan TH, Feller SM | title = The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins | journal = Oncogene | volume = 17 | issue = 15 | pages = 1893–901 | year = 1998 | pmid = 9788432 | doi = 10.1038/sj.onc.1202108 }}
29. ^{{cite journal |vauthors=Ling P, Yao Z, Meyer CF, Wang XS, Oehrl W, Feller SM, Tan TH | title = Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase | journal = Mol. Cell. Biol. | volume = 19 | issue = 2 | pages = 1359–68 | year = 1999 | pmid = 9891069 | pmc = 116064 | doi = }}
30. ^{{cite journal |vauthors=Ling P, Meyer CF, Redmond LP, Shui JW, Davis B, Rich RR, Hu MC, Wange RL, Tan TH | title = Involvement of hematopoietic progenitor kinase 1 in T cell receptor signaling | journal = J. Biol. Chem. | volume = 276 | issue = 22 | pages = 18908–14 | year = 2001 | pmid = 11279207 | doi = 10.1074/jbc.M101485200 }}
31. ^{{cite journal |vauthors=Girardin SE, Yaniv M | title = A direct interaction between JNK1 and CrkII is critical for Rac1-induced JNK activation | journal = EMBO J. | volume = 20 | issue = 13 | pages = 3437–46 | year = 2001 | pmid = 11432831 | pmc = 125507 | doi = 10.1093/emboj/20.13.3437 }}
32. ^{{cite journal |vauthors=Minegishi M, Tachibana K, Sato T, Iwata S, Nojima Y, Morimoto C | title = Structure and function of Cas-L, a 105-kD Crk-associated substrate-related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes | journal = J. Exp. Med. | volume = 184 | issue = 4 | pages = 1365–75 | year = 1996 | pmid = 8879209 | pmc = 2192828 | doi = 10.1084/jem.184.4.1365}}
33. ^{{cite journal |vauthors=Ohashi Y, Tachibana K, Kamiguchi K, Fujita H, Morimoto C | title = T cell receptor-mediated tyrosine phosphorylation of Cas-L, a 105-kDa Crk-associated substrate-related protein, and its association of Crk and C3G | journal = J. Biol. Chem. | volume = 273 | issue = 11 | pages = 6446–51 | year = 1998 | pmid = 9497377 | doi = 10.1074/jbc.273.11.6446}}
34. ^{{cite journal |vauthors=Yokote K, Hellman U, Ekman S, Saito Y, Rönnstrand L, Saito Y, Heldin CH, Mori S | title = Identification of Tyr-762 in the platelet-derived growth factor alpha-receptor as the binding site for Crk proteins | journal = Oncogene | volume = 16 | issue = 10 | pages = 1229–39 | year = 1998 | pmid = 9546424 | doi = 10.1038/sj.onc.1201641 }}
35. ^1 {{cite journal |vauthors=Matsumoto T, Yokote K, Take A, Takemoto M, Asaumi S, Hashimoto Y, Matsuda M, Saito Y, Mori S | title = Differential interaction of CrkII adaptor protein with platelet-derived growth factor alpha- and beta-receptors is determined by its internal tyrosine phosphorylation | journal = Biochem. Biophys. Res. Commun. | volume = 270 | issue = 1 | pages = 28–33 | year = 2000 | pmid = 10733900 | doi = 10.1006/bbrc.2000.2374 }}
36. ^{{cite journal |vauthors=Abassi YA, Vuori K | title = Tyrosine 221 in Crk regulates adhesion-dependent membrane localization of Crk and Rac and activation of Rac signaling | journal = EMBO J. | volume = 21 | issue = 17 | pages = 4571–82 | year = 2002 | pmid = 12198159 | pmc = 126186 | doi = 10.1093/emboj/cdf446}}
37. ^{{cite journal |vauthors=Tanaka S, Morishita T, Hashimoto Y, Hattori S, Nakamura S, Shibuya M, Matuoka K, Takenawa T, Kurata T, Nagashima K | title = C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 91 | issue = 8 | pages = 3443–7 | year = 1994 | pmid = 7512734 | pmc = 43593 | doi = 10.1073/pnas.91.8.3443}}
38. ^{{cite journal |vauthors=Zhao C, Ma H, Bossy-Wetzel E, Lipton SA, Zhang Z, Feng GS | title = GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2 | journal = J. Biol. Chem. | volume = 278 | issue = 36 | pages = 34641–53 | year = 2003 | pmid = 12819203 | doi = 10.1074/jbc.M304594200 }}
39. ^{{cite journal |vauthors=Moon SY, Zang H, Zheng Y | title = Characterization of a brain-specific Rho GTPase-activating protein, p200RhoGAP | journal = J. Biol. Chem. | volume = 278 | issue = 6 | pages = 4151–9 | year = 2003 | pmid = 12454018 | doi = 10.1074/jbc.M207789200 }}
40. ^{{cite journal |vauthors=Watanabe S, Take H, Takeda K, Yu ZX, Iwata N, Kajigaya S | title = Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes | journal = Biochem. Biophys. Res. Commun. | volume = 278 | issue = 1 | pages = 167–74 | year = 2000 | pmid = 11071869 | doi = 10.1006/bbrc.2000.3760 }}

Further reading

{{Refbegin|35em}}
  • {{Cite journal |vauthors=Feller SM, Ren R, Hanafusa H, Baltimore D |title=SH2 and SH3 domains as molecular adhesives: the interactions of Crk and Abl. |journal=Trends Biochem. Sci. |volume=19 |issue= 11 |pages= 453–8 |year= 1995 |pmid= 7855886 |doi=10.1016/0968-0004(94)90129-5 }}
  • {{Cite journal |vauthors=Feller SM, Posern G, Voss J |title=Physiological signals and oncogenesis mediated through Crk family adapter proteins. |journal=J. Cell. Physiol. |volume=177 |issue= 4 |pages= 535–52 |year= 1999 |pmid= 10092207 |doi= 10.1002/(SICI)1097-4652(199812)177:4<535::AID-JCP5>3.0.CO;2-E |display-authors=etal}}
  • {{Cite journal |vauthors=Pessin JE, Okada S |title=Insulin and EGF receptors integrate the Ras and Rap signaling pathways. |journal=Endocr. J. |volume=46 Suppl |pages= S11–6 |year= 2002 |pmid= 12054111 |doi=10.1507/endocrj.46.suppl_s11}}
  • {{Cite journal |vauthors=Cicchetti P, Mayer BJ, Thiel G, Baltimore D |title=Identification of a protein that binds to the SH3 region of Abl and is similar to Bcr and GAP-rho. |journal=Science |volume=257 |issue= 5071 |pages= 803–6 |year= 1992 |pmid= 1379745 |doi=10.1126/science.1379745 }}
  • {{Cite journal |vauthors=Matsuda M, Tanaka S, Nagata S |title=Two species of human CRK cDNA encode proteins with distinct biological activities. |journal=Mol. Cell. Biol. |volume=12 |issue= 8 |pages= 3482–9 |year= 1992 |pmid= 1630456 | pmc=364597 |display-authors=etal}}
  • {{Cite journal |vauthors=Anderson D, Koch CA, Grey L |title=Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors. |journal=Science |volume=250 |issue= 4983 |pages= 979–82 |year= 1990 |pmid= 2173144 |doi=10.1126/science.2173144 |display-authors=etal}}
  • {{Cite journal |vauthors=Schaller MD, Hildebrand JD, Shannon JD |title=Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src. |journal=Mol. Cell. Biol. |volume=14 |issue= 3 |pages= 1680–8 |year= 1994 |pmid= 7509446 | pmc=358526 |display-authors=etal}}
  • {{Cite journal |vauthors=Hempstead BL, Birge RB, Fajardo JE |title=Expression of the v-crk oncogene product in PC12 cells results in rapid differentiation by both nerve growth factor- and epidermal growth factor-dependent pathways. |journal=Mol. Cell. Biol. |volume=14 |issue= 3 |pages= 1964–71 |year= 1994 |pmid= 7509449 | pmc=358555 |display-authors=etal}}
  • {{Cite journal |vauthors=Tanaka S, Morishita T, Hashimoto Y |title=C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 8 |pages= 3443–7 |year= 1994 |pmid= 7512734 |doi=10.1073/pnas.91.8.3443 | pmc=43593 |display-authors=etal}}
  • {{Cite journal |vauthors=Calalb MB, Polte TR, Hanks SK |title=Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases. |journal=Mol. Cell. Biol. |volume=15 |issue= 2 |pages= 954–63 |year= 1995 |pmid= 7529876 | pmc=231984 }}
  • {{Cite journal |vauthors=Teng KK, Lander H, Fajardo JE |title=v-Crk modulation of growth factor-induced PC12 cell differentiation involves the Src homology 2 domain of v-Crk and sustained activation of the Ras/mitogen-activated protein kinase pathway. |journal=J. Biol. Chem. |volume=270 |issue= 35 |pages= 20677–85 |year= 1995 |pmid= 7657647 |doi=10.1074/jbc.270.35.20677 |display-authors=etal}}
  • {{Cite journal |vauthors=Schumacher C, Knudsen BS, Ohuchi T |title=The SH3 domain of Crk binds specifically to a conserved proline-rich motif in Eps15 and Eps15R. |journal=J. Biol. Chem. |volume=270 |issue= 25 |pages= 15341–7 |year= 1995 |pmid= 7797522 |doi=10.1074/jbc.270.25.15341 |display-authors=etal}}
  • {{Cite journal |vauthors=Matsuda M, Hashimoto Y, Muroya K |title=CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cells. |journal=Mol. Cell. Biol. |volume=14 |issue= 8 |pages= 5495–500 |year= 1994 |pmid= 8035825 | pmc=359069 |display-authors=etal}}
  • {{Cite journal |vauthors=Feller SM, Knudsen B, Hanafusa H |title=c-Abl kinase regulates the protein binding activity of c-Crk. |journal=EMBO J. |volume=13 |issue= 10 |pages= 2341–51 |year= 1994 |pmid= 8194526 | pmc=395099 }}
  • {{Cite journal |vauthors=Fioretos T, Heisterkamp N, Groffen J |title=CRK proto-oncogene maps to human chromosome band 17p13. |journal=Oncogene |volume=8 |issue= 10 |pages= 2853–5 |year= 1993 |pmid= 8378094 |display-authors=etal}}
  • {{Cite journal |vauthors=Smit L, van der Horst G, Borst J |title=Sos, Vav, and C3G participate in B cell receptor-induced signaling pathways and differentially associate with Shc-Grb2, Crk, and Crk-L adaptors. |journal=J. Biol. Chem. |volume=271 |issue= 15 |pages= 8564–9 |year= 1996 |pmid= 8621483 |doi=10.1074/jbc.271.15.8564 }}
  • {{Cite journal |vauthors=Beitner-Johnson D, Blakesley VA, Shen-Orr Z |title=The proto-oncogene product c-Crk associates with insulin receptor substrate-1 and 4PS. Modulation by insulin growth factor-I (IGF) and enhanced IGF-I signaling. |journal=J. Biol. Chem. |volume=271 |issue= 16 |pages= 9287–90 |year= 1996 |pmid= 8621590 |doi=10.1074/jbc.271.16.9287|display-authors=etal}}
  • {{Cite journal |vauthors=Hasegawa H, Kiyokawa E, Tanaka S |title=DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane. |journal=Mol. Cell. Biol. |volume=16 |issue= 4 |pages= 1770–6 |year= 1996 |pmid= 8657152 | pmc=231163 |display-authors=etal}}
{{Refend}}{{PDB Gallery|geneid=1398}}

External links

  • [https://web.archive.org/web/20110722012647/http://cmkb.cellmigration.org/report.cgi?report=orth_overview&gene_id=1398 Crk] Info with links in the Cell Migration Gateway
  • {{MeshName|Proto-Oncogene+Proteins+c-crk}}
  • {{MeshName|Oncogene+Protein+v-crk}}
  • {{UCSC gene info|CRK}}

2 : Genes|Human proteins
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