Moldovan clubs have participated since 2001, when Codru entered the 2001–02 UEFA Women's Cup.[1][2][3][4][5][6][7]
| Season | Club | Opponent | >Away | UEFA Women's Cup | | 2001–02 | Codru Chișinău | Qualifying round | {{flagicon|SLO}} Ilirija Ljubljana | 9–0 | 9–0 | 18–0 |
Group 4
{{flagicon|GER}} (host) | {{flagicon|ARM}} College Yerevan | 9–0 | 3rd | |
| {{flagicon|GER}} Frankfurt | 0–5 |
| {{flagicon|SPA}} Levante | 1–3 |
| 2002–03 | Codru Anenii Noi | Group 6
{{flagicon|BLR}} (host) | {{flagicon|DEN}} Fortuna Hjørring | 0–5 | 4th | |
| {{flagicon|BLR}} Bobruichanka | 0–6 |
| {{flagicon|ISL}} Breiðablik | 0–2 |
| 2003–04 | Codru Anenii Noi | Group 8
{{flagicon|NED}} (host) | {{flagicon|NED}} Ter Leede | 0–8 | 3rd | |
| {{flagicon|ENG}} Fulham London | 1–9 |
| {{flagicon|FAR}} KÍ Klaksvík | 5–3 |
| 2004–05 | Codru Anenii Noi | First qualifying round
Group A3
{{flagicon|BLR}} (host) | {{flagicon|BLR}} Bobruichanka | 0–2 | 2nd | |
| {{flagicon|HUN}} Viktória Szombathely | 1–1 |
| {{flagicon|EST}} Pärnu | 5–1 |
| 2005–06 | Codru Anenii Noi | First qualifying round
Group A5
{{flagicon|MKD}} (host) | {{flagicon|MKD}} Skiponjat | 4–1 | 2nd | |
| {{flagicon|FAR}} KÍ Klaksvík | 4–1 |
| {{flagicon|SUI}} LUwin.ch | 0–4 |
| 2006–07 | Narta Chișinău | First qualifying round
Group A9
{{flagicon|BUL}} (host) | {{flagicon|BUL}} NSA Sofia | 1–3 | 3rd | |
| {{flagicon|AZE}} Gömrükçü Baku | 2–1 |
| {{flagicon|HUN}} Femina Budapest | 0–7 |
| 2007–08 | Narta Chișinău | First qualifying round
Group A9
{{flagicon|MDA}} (host) | {{flagicon|KAZ}} Alma | 0–5 | 3rd | |
| {{flagicon|HUN}} Femina Budapest | 0–2 |
| {{flagicon|AZE}} Ruslan-93 | 3–1 |
| 2008–09 | Narta Chișinău | First qualifying round
Group A2
{{flagicon|SRB}} (host) | {{flagicon|SRB}} Mašinac Niš | 1–15 | 4th | |
| {{flagicon|NED}} AZ Alkmaar | 0–7 |
| {{flagicon|SCO}} Glasgow City | 0–11 |
| UEFA Women's Champions League |
| 2009–10 | Roma Calfa | Qualifying round
Group 5
{{flagicon|SWE}} (host) | {{flagicon|SWE}} Linköping | 0–11 | 4th | |
| {{flagicon|ROU}} Clujana | 0–9 |
| {{flagicon|NIR}} Glentoran Belfast | 0–2 |
| 2010–11 | Roma Calfa | Qualifying round
Group 1
{{flagicon|DEN}} (host) | {{flagicon|DEN}} Brøndby | 0–6 | 3rd | |
| {{flagicon|BUL}} NSA Sofia | 0–4 |
| {{flagicon|TUR}} Gazi Üniversitesi | 3–3 |
| 2011–12 | Goliador Chișinău | Qualifying round
Group 1
{{flagicon|MKD}} (host) | {{flagicon|GRE}} PAOK | 0–3 | 4th | |
| {{flagicon|SUI}} Young Boys Bern | 0–7 |
| {{flagicon|MKD}} Naše Taksi | 0–6 |
| 2012–13 | Noroc Nimoreni | Qualifying round
Group 8
{{flagicon|FIN}} (host) | {{flagicon|FIN}} PK-35 Vantaa | 0–6 | 4th | |
| {{flagicon|SCO}} Glasgow City | 0–11 |
| {{flagicon|CRO}} Osijek | 1–11 |
| 2013–14 | Goliador Chișinău | Qualifying round
Group 7
{{flagicon|CYP}} (host) | {{flagicon|ISR}} ASA Tel Aviv | 0–6 | 4th | |
| {{flagicon|CYP}} Apollon Limassol | 0–1 |
| {{flagicon|SVK}} Union Nové Zámky | 0–6 |
| 2014–15 | Goliador-Real Chișinău | Qualifying round
Group 5
{{flagicon|CRO}} (host) | {{flagicon|CRO}} Osijek | 0–12 | 4th | |
| {{flagicon|SRB}} Spartak Subotica | 0–19 |
| {{flagicon|GRE}} Amazones Dramas | 0–11 |
| 2015–16 | Noroc Nimoreni | Qualifying round
Group 6
{{flagicon|CRO}} (host) | {{flagicon|CRO}} Osijek | 0–4 | 4th | |
| {{flagicon|SRB}} Spartak Subotica | 1–4 |
| {{flagicon|POR}} Benfica | 0–3 |
| 2016–17 | ARF Criuleni | Qualifying round
Group 7
{{flagicon|IRL}} (host) | {{flagicon|LIT}} Gintra Universitetas | 0–13 | 4th | |
| {{flagicon|KAZ}} BIIK Kazygurt | 0–3 |
| {{flagicon|IRL}} Wexford | 0–0 |
| 2017–18 | Noroc Nimoreni | Qualifying round
Group 5
{{flagicon|CYP}} (host) | {{flagicon|AUT}} Sturm Graz | 0–4 | 4th | |
| {{flagicon|CYP}} Apollon Limassol | 0–6 |
| {{flagicon|BUL}} NSA Sofia | 0–1 |
| 2018–19 | Agarista Anenii Noi | Qualifying round
Group 8
{{flagicon|BIH}} (host) | {{flagicon|EST}} Pärnu | 0–2 | 4th | |
| {{flagicon|BIH}} Sarajevo | 0–5 |
| {{flagicon|ALB}} Vllaznia Shkodër | 1–4 |
1. ^1 Codru in UEFA competitions
2. ^1 Narta in UEFA competitions
3. ^1 Roma in UEFA competitions
4. ^1 Goliador in UEFA competitions
5. ^1 [https://www.uefa.com/teamsandplayers/teams/club=2604549/profile/index.html Noroc in UEFA competitions]
6. ^1 [https://www.uefa.com/teamsandplayers/teams/club=2607631/profile/index.html Criuleni in UEFA competitions]
7. ^1 [https://www.uefa.com/womenschampionsleague/season=2019/clubs/club=2605082/index.html Agarista in UEFA competitions]