| 词条 | Mrp superfamily |
| 释义 |
The Na+ Transporting Mrp Superfamily is a superfamily of integral membrane transport proteins. It includes the TC families: 2.A.63 - The Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) Family3.D.1 - The H+ or Na+-translocating NADH Dehyrogenase (NDH) Family3.D.9 - The H+-translocating F420H2 Dehydrogenase (F420H2DH) FamilyMrp of Bacillus subtilis is a 7 subunit Na+/H+ antiporter complex (TC# 2.A.63.1.4). All subunits are homologous to the subunits in other members of this monovalent cation (K+ or Na+):proton antiporter-3 (CPA3) family as well as subunits in the archaeal hydrogenases (TC#s 3.D.1.4.1 and 3.D.1.4.2), which share several subunits with NADH dehydrogenase subunits (3.D.1). The largest subunits of the Mrp complex (MrpA and MrpD) are homologous to subunits in NADH dehydrogenases (NDHs): ND2, ND4 and ND5 in the fungal NADH dehydrogenase complex and most other NDHs, as well as subunits in the F420H2 dehydrogenase of Methanosarcina mazei (TC#3.D.9.1.1).[1] These homologous subunits may catalyze Na+/K+ and/or H+ transport. See also
References1. ^{{Cite journal|last=Zickermann|first=Volker|last2=Wirth|first2=Christophe|last3=Nasiri|first3=Hamid|last4=Siegmund|first4=Karin|last5=Schwalbe|first5=Harald|last6=Hunte|first6=Carola|last7=Brandt|first7=Ulrich|date=2015-01-02|title=Structural biology. Mechanistic insight from the crystal structure of mitochondrial complex I|journal=Science |volume=347|issue=6217|pages=44–49|doi=10.1126/science.1259859|issn=1095-9203|pmid=25554780}} {{CCBYSASource|sourcepath=http://tcdb.org/superfamily.php?id=72|sourcearticle=Na+ Transporting Mrp Superfamily|revision=699838558}} 6 : Protein superfamilies|Membrane proteins|Transmembrane proteins|Transmembrane transporters|Transport proteins|Integral membrane proteins |
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